chemokines and neuroendocrine pathways

April 21, 2007

" ...Very recent evidence thus suggests that chemokines may be added to

the multiple peptides involved in the regulation of neuroendocrine

pathways. This topic is of emerging significance. Although expressed at

a much lower concentration in the brain than in other known regulatory

peptides, chemokines are able to play a subtle but essential role in

hormonal regulation, both in the brain and at the pituitary level. It

represents a step forward in our knowledge in neuroendocrine regulation.

Chemokines and their receptors, by their presence in hypothalamic

neurons, can be considered as possible novel direct neuromodulators of

hormone release and not, as previously thought, as the sole effectors in

neuroimmunomodulati

on..

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