Guest guest Posted March 29, 2006 Report Share Posted March 29, 2006 J Neuroimmunol. 2006 Mar;172(1-2):198-205. Epub 2005 Dec 19. Elevated cytokine levels in children with autism spectrum disorder. Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K, Manning- P, Altaye M, Wills-Karp M. Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5041, Cincinnati, OH 45229-3039, United States; Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 4002, Cincinnati, OH 45229-3039, United States; Department of Pediatrics, University of Cincinnati College of Medicine, United States. This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-gamma/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls. Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10. Quote Link to comment Share on other sites More sharing options...
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