ot: Retinoic acid for Alzheimer's disease

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*/Retinoic/ acid is a metabolite of vitamin A* (retinol) that mediates

the functions of vitamin A required for growth and development...

http://en.wikipedia.org/wiki/Retinoic_acid

*/Retinoic acid attenuates beta-amyloid deposition and rescues memory

deficits in an Alzheimer's disease transgenic mouse model/*

Ding Y et al.

J Neurosci. 2008 Nov 5;28(45):11622-34.

http://www.ncbi.nlm.nih.gov/pubmed/18987198

pdf:

http://www.jneurosci.org/cgi/content/full/28/45/11622

See also:

*/Towards retinoid therapy for Alzheimer's disease./*

Shudo K, Fukasawa H, Nakagomi M, Yamagata N.

Curr Alzheimer Res. 2009 Jun;6(3):302-11.

http://www.ncbi.nlm.nih.gov/pubmed/19519313

*/Retinoic acid receptor-? signalling antagonizes both intracellular and

extracellular amyloid-? production and prevents neuronal cell death

caused by amyloid-?/*

Jarvis CI et al.

Eur J Neurosci. 2010 Oct;32(8):1246-55.

http://www.ncbi.nlm.nih.gov/pubmed/20950278

*/

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's

disease./*

Lee HP et al.

Expert Rev Neurother. 2009 Nov;9(11):1615-21.

http://www.ncbi.nlm.nih.gov/pubmed/19903021

*/Gene-environment interaction research and transgenic mouse models of

Alzheimer's disease./*

Chouliaras L et al.

Int J Alzheimers Dis. 2010 Oct 5;2010. pii: 859101.

http://www.ncbi.nlm.nih.gov/pubmed/20953364

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