18 Novel Subtype-Dependent Genetic Variants for Autism Spectrum Disorders and Identify Potential Genetic Markers for Diagnostic Screening

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Researchers Reveal 18 Novel Subtype-Dependent Genetic Variants for

Autism Spectrum Disorders and Identify Potential Genetic Markers for

Diagnostic Screening

http://www.sciencedaily.com/releases/2011/04/110427171517.htm

ScienceDaily (Apr. 28, 2011) --- By dividing individuals with autism

spectrum disorders (ASD) into four subtypes according to similarity of

symptoms and reanalyzing existing genome-wide genetic data on these

individuals vs. controls, researchers at the Washington

University School of Medicine and Health Sciences have identified 18

novel and highly significant genetic markers for ASD. In addition, ten

of the variants were associated with more than one ASD subtype,

providing partial replication of these genetic markers. This study thus

identifies candidate genes for ASD and potential subtype-dependent

genetic markers for diagnostic screening...

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open access:

W. Hu, Anjene Addington, Hyman. *

Novel Autism Subtype-Dependent Genetic Variants Are Revealed by

Quantitative Trait and Subphenotype Association Analyses of Published

GWAS Data*. /PLoS ONE/, 2011; 6 (4): e19067

DOI: 10.1371/journal.pone.0019067

<http://dx.doi.org/10.1371/journal.pone.0019067>