IFNg & vax - MHC immune molecule and synapse density in brain

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Mayo's Greg Poland and others have documented that, among humans, some

MHC alleles are associated with either hypo- or hyper-responsiveness to

specific antigens, including vaccinal antigens. The new findings by

Glynn et al (1) suggest a physiological domain susceptible to injury in

some individuals during natural or medically induced immune stimulation

(eg, IFNg in 2-3).

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1. MHC article is free online

http://www.nature.com/neuro/journal/vaop/ncurrent/pdf/nn.2764.pdf

n W Glynn, Bradford M Elmer, a A Garay, Xiao-Bo Liu, Leigh A

Needleman, Faten El-Sabeawy & A Kimberley McAllister. *MHCI negatively

regulates synapse density during the establishment of cortical

connections*. /Nature Neuroscience/, 27 February 2011 DOI:

10.1038/nn.2764 <http://dx.doi.org/10.1038/nn.2764>

2. Kinetics of immunologic responses after primary MMR vaccination.

<http://www.ncbi.nlm.nih.gov/pubmed/9041660>

Pabst HF, Spady DW, Carson MM, Stelfox HT, Beeler JA, Krezolek MP.

Vaccine. 1997 Jan;15(1):10-4.

3. Major histocompatibility complex (MHC) class I gene expression in

single neurons of the central nervous system: differential regulation by

interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha.

<http://www.ncbi.nlm.nih.gov/pubmed/9016879>

Neumann H, Schmidt H, Cavalié A, Jenne D, Wekerle H.

J Exp Med. 1997 Jan 20;185(2):305-16.