HHV-6 antibody responses following measles infection, vaccination

[Guest guest]

HHV-6 IgG4 isotype response following measles infection.

<http://www.ncbi.nlm.nih.gov/pubmed/20087929>

Ferreyra L, Bustos D, Biganzoli P, Isa MB, Don PS, Ribechini E, Nates

SV, Pavan JV.

J Med Virol. 2010 Mar;82(3):396-9.

Human herpesvirus 6 (HHV-6) is widespread in the human population by

infecting most individuals in early childhood. After primary infection,

HHV-6 establishes a latent infection by remaining in circulating

mononuclear cells of healthy individuals. The HHV-6 antibody titer

increases after primary infection with measles virus. The present study

was undertaken to determine the specific antiviral IgG1, IgG2, IgG3, and

IgG4 subclass response patterns to HHV-6 in HHV-6-seropositive

individuals with natural measles virus infection, measles vaccination,

and rubella virus infection. The purpose of this study was to examine

HHV-6-specific IgG isotype response in patients with acute virus

coinfection.

Serum samples were obtained from individuals who were seropositive for

HHV-6 after natural primary infection with measles virus during an

outbreak, measles vaccination, or rubella virus infection, and from

healthy individuals. Sera were examined by indirect immunofluorescence

assays for detection of HHV-6-specific IgG1, IgG2, IgG3, and IgG4

antibodies.

A high percentage (69%) of those infected with measles virus had an

HHV-6 IgG1 and IgG4 response (P<0.001, ?2 test), whereas persons

vaccinated against measles, those infected with rubella, and healthy

individuals showed an HHV-6 IgG1 response. These results demonstrate

that natural measles virus infection induces an HHV-6 IgG isotype

response, which suggests a shift in immune activity from a Th1 to a Th2

response.

J. Med. Virol. 82:396--399, 2010. © 2010 Wiley-Liss, Inc