re: Autism linked to hundreds of genetic mutations - aluminum adjuvants and thimerosal

[Guest guest]

Perhaps aluminum adjuvants and thimerosal are contributing to the DNA

aberrations described in autism

Genotoxic effects of aluminum, iron and manganese in human cells and

experimental systems: A review of the literature.

<http://www.ncbi.nlm.nih.gov/pubmed/21247993>

Lima P, Vaconcellos M, Montenegro R, Bahia M, Antunes L, Costa E, Burbano R.

Hum Exp Toxicol. 2011 Jan 19.

Aluminum-induced micronuclei and apoptosis in human peripheral-blood

lymphocytes treated during different phases of the cell cycle.

<http://www.ncbi.nlm.nih.gov/pubmed/16007643>

Banasik A, Lankoff A, Piskulak A, Adamowska K, Lisowska H, Wojcik A.

Environ Toxicol. 2005 Aug;20(4):402-6.

Genotoxicity of thimerosal in cultured human lymphocytes with and

without metabolic activation sister chromatid exchange analysis

proliferation index and mitotic index.

<http://www.ncbi.nlm.nih.gov/pubmed/18321677>

Eke D, Celik A.

Toxicol In Vitro. 2008 Jun;22(4):927-34.

Thimerosal induces micronuclei in the cytochalasin B block micronucleus

test with human lymphocytes. <http://www.ncbi.nlm.nih.gov/pubmed/12491041>

Westphal GA, Asgari S, Schulz TG, Bünger J, Müller M, Hallier E.

Arch Toxicol. 2003 Jan;77(1):50-5.

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Autism linked to hundreds of genetic mutations

Three new studies conclude that autism disorders are

genetically very complex, not caused by one or two gene

defects. The potential changes in DNA may produce what are

essentially different forms of autism.

http://www.latimes.com/health/la-he-autism-20110609,0,2892508.story

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High Risk Genomic Loci in ASD

Studies by Levy et al.

<http://www.cell.com/neuron/abstract/S0896-6273%2811%2900396-5> and

et al.

<http://www.cell.com/neuron/abstract/S0896-6273%2811%2900374-6> examine

the contribution of rare de novo genomic copy number variations (CNVs)

in a large collection of families with one child with autism spectrum

disorder (ASD) and revealed a number of loci associated with higher risk

of ASD. In a related study, Gilman et al.

<http://www.cell.com/neuron/abstract/S0896-6273%2811%2900439-9> used a

novel network analysis approach to identify a network of genes affected

by these rare de novo CNVs. Preview by Schaaf and Zoghbi

<http://www.cell.com/neuron/abstract/S0896-6273%2811%2900443-0>.