Guest guest Posted March 27, 2006 Report Share Posted March 27, 2006 Subject: Re: Re: Brain Endothelial Antibodies in Children with Language Regression from Autism-Immune: I've been searching through my documents to see if I could find a band that would correspond to 47 kDa but I've come up empty handed. The closest I've found is Singh's 49 kDa possible autoantigen: Prevalence of serum antibodies to caudate nucleus in autistic children Vijendra K. Singh, and Wyatt H. Rivas Department of Biology, Biotechnology Center Building, Utah State University, 4700 Old Main Hill, Logan, UT 84322-4700, USA Received 3 July 2003; revised 15 October 2003; accepted 15 October 2003. ; Available online 10 December 2003. Abstract Autism may involve autoimmunity to brain. We studied regional distribution of antibodies to rat caudate nucleus, cerebral cortex, cerebellum, brain stem and hippocampus. The study included 30 normal and 68 autistic children. Antibodies were assayed by immunoblotting. Autistic children, but not normal children, had antibodies to caudate nucleus (49% positive sera), cerebral cortex (18% positive sera) and cerebellum (9% positive sera). Brain stem and hippocampus were negative. Antibodies to caudate nucleus were directed towards three proteins having 160, 115 and 49 kD molecular weights. Since a significant number of autistic children had antibodies to caudate nucleus, we propose that an autoimmune reaction to this brain region may cause neurological impairments in autistic children. Thus, the caudate nucleus might be involved in the neurobiology of autism. Author Keywords: Autism; Autoimmunity; Caudate nucleus; Antibodies; Neurobiology Quote Link to comment Share on other sites More sharing options...
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