Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids

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Relevance to autism (2-3):

1. Regression of gastroesophageal reflux disease symptoms using dietary

supplementation with melatonin, vitamins and aminoacids: comparison with

omeprazole. <http://www.ncbi.nlm.nih.gov/pubmed/16948779>

Pereira Rde S.

J Pineal Res. 2006 Oct;41(3):195-200.

The prevalence of gastroesophageal reflux disease (GERD) is increasing.

GERD is a chronic disease and its treatment is problematic. It may

present with various symptoms including heartburn, regurgitation,

dysphagia, coughing, hoarseness or chest pain. The aim of this study was

to investigate if a dietary supplementation containing: melatonin,

l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and

betaine would help patients with GERD, and to compare the preparation

with 20 mg omeprazole. Melatonin has known inhibitory activities on

gastric acid secretion and nitric oxide biosynthesis. Nitric oxide has

an important role in the transient lower esophageal sphincter relaxation

(TLESR), which is a major mechanism of reflux in patients with GERD.

Others biocompounds of the formula display anti-inflammatory and

analgesic effects. A single blind randomized study was performed in

which 176 patients underwent treatment using the supplement cited above

(group A) and 175 received treatment of 20 mg omeprazole (group .

Symptoms were recorded in a diary and changes in severity of symptoms

noted. */All patients of the group A (100%) reported a complete

regression of symptoms after 40 days of treatment. On the other hand,

115 subjects (65.7%) of the omeprazole reported regression of symptoms

in the same period./* There was statiscally significant difference

between the groups (P < 0.05). This formulation promotes regression of

GERD symptoms with no significant side effects.

2. Incidence of gastrointestinal symptoms in children with autism: a

population-based study. <http://www.ncbi.nlm.nih.gov/pubmed/19651585>

Ibrahim SH, Voigt RG, Katusic SK, Weaver AL, Barbaresi WJ.

Pediatrics. 2009 Aug;124(2):680-6. Epub 2009 Jul 27.

3. Recommendations for evaluation and treatment of common

gastrointestinal problems in children with ASDs.

<http://www.ncbi.nlm.nih.gov/pubmed/20048084>

Buie T, Fuchs GJ 3rd, Furuta GT, Kooros K, Levy J, JD, Wershil BK,

Winter H.

Pediatrics. 2010 Jan;125 Suppl 1:S19-29.