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Association between Autism Prevalence and Childhood Vaccination uptake across the U.S. Population

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A Positive Association found between Autism Prevalence and Childhood

Vaccination uptake across the U.S. Population.

<http://www.ncbi.nlm.nih.gov/pubmed/21623535>

Delong G.

J Toxicol Environ Health A. 2011 Jan;74(14):903-16.

pdf here <http://tinyurl.com/3p2cd5z>

The reason for the rapid rise of autism in the United States that began

in the 1990s is a mystery. Although individuals probably have a genetic

predisposition to develop autism, researchers suspect that one or more

environmental triggers are also needed. One of those triggers might be

the battery of vaccinations that young children receive. Using

regression analysis and controlling for family income and ethnicity, the

relationship between the proportion of children who received the

recommended vaccines by age 2 years and the prevalence of autism (AUT)

or speech or language impairment (SLI) in each U.S. state from 2001 and

2007 was determined. A positive and statistically significant

relationship was found: The higher the proportion of children receiving

recommended vaccinations, the higher was the prevalence of AUT or SLI. A

1% increase in vaccination was associated with an additional 680

children having AUT or SLI. Neither parental behavior nor access to care

affected the results, since vaccination proportions were not

significantly related (statistically) to any other disability or to the

number of pediatricians in a U.S. state. The results suggest that

although mercury has been removed from many vaccines, other culprits may

link vaccines to autism. Further study into the relationship between

vaccines and autism is warranted.

see also, " non-specific effects " as a concept in:

Non-specific and sex-differential effects of routine vaccines: What

evidence is needed to take these effects into consideration in

low-income countries? <http://www.ncbi.nlm.nih.gov/pubmed/21278492>

Aaby P, Benn CS.

Hum Vaccin. 2011 Jan 1;7(1):120-4.

None of the original vaccines used in the child immunization programmes

in low-income countries, including BCG, diphtheria-tetanus-pertussis

(DTP), oral polio vaccine (OPV), and measles vaccine (MV), were tested

for their overall effect on child mortality before being introduced. It

was assumed that the effect on overall child mortality would be

equivalent to the proportion of deaths caused by the targeted disease(s)

(1). However, this is no longer a tenable assumption. Many studies have

shown that these routine vaccines may have more general effects on the

immune system than merely protecting against the targeted disease, i.e.

so-called non-specific effects (NSE) (2). The NSE may well be more

important for overall child survival than the lives saved by specific

disease prevention (2-4)....

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