Familial Autoimmune Thyroid Disease as a Risk Factor for Regression

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Familial Autoimmune Thyroid Disease as a Risk Factor for Regression

in Children with Autism Spectrum Disorder: A CPEA Study.

Molloy CA, Morrow AL, Meinzen-Derr J, Dawson G, Bernier R, Dunn M,

Hyman SL, McMahon WM, Goudie-Nice J, Hepburn S, Minshew N, S,

Sigman M, Spence MA, Tager-Flusberg H, Volkmar FR, Lord C.

Center for Epidemiology and Biostatistics, Cincinnati Children's

Hospital Medical Center, University of Cincinnati College of

Medicine, Cincinnati, Ohio, USA.

A multicenter study of 308 children with Autism Spectrum Disorder

(ASD) was conducted through the Collaborative Programs of Excellence

in Autism (CPEA), sponsored by the National Institute of Child

Health and Human Development, to compare the family history of

autoimmune disorders in children with ASD with and without a history

of regression. A history of regression was determined from the

results of the Autism Diagnostic Interview-Revised (ADI-R). Family

history of autoimmune disorders was obtained by telephone interview.

Regression was significantly associated with a family history of

autoimmune disorders (adjusted OR=1.89; 95% CI: 1.17, 3.10). The

only specific autoimmune disorder found to be associated with

regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI:

1.28, 3.41).