re: Autoimmune/inflammatory syndrome induced by adjuvants

[Guest guest]

Fascinating, may I re-post?

________________________________

Sent: Mon, February 14, 2011 11:35:14 AM

Subject: Autoimmune/inflammatory syndrome induced by adjuvants

Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA):

Old truths and a new syndrome? <http://www.ncbi.nlm.nih.gov/pubmed/21051205>

Meroni PL.

J Autoimmun. 2011 Feb;36(1):1-3. Epub 2010 Nov 3.

There has been considerable interest in the role of environmental

factors and the induction of autoimmunity and the ways by which they

facilitate loss of tolerance. Clearly both genetic and environmental

factors are incriminated, as evidenced by the lack of concordance in

identical twins and the relatively recent identification of the shared

epitope in rheumatoid arthritis. In this issue a new syndrome called

'Asia'-autoimmune/auto-inflammatory syndrome induced by adjuvants has

been proposed. It is an intriguing issue and one that is likely to be

provocative and lead to further biologic and molecular investigations.

'ASIA' - Autoimmune/inflammatory syndrome induced by adjuvants.

<http://www.ncbi.nlm.nih.gov/pubmed/20708902>

Shoenfeld Y, Agmon-Levin N.

J Autoimmun. 2011 Feb;36(1):4-8. Epub 2010 Aug 13.

The role of various environmental factors in the pathogenesis of immune

mediated diseases is well established. Of which, factors entailing an

immune adjuvant activity such as infectious agents, silicone, aluminium

salts and others were associated with defined and non-defined immune

mediated diseases both in animal models and in humans. In recent years,

four conditions: siliconosis, the Gulf war syndrome (GWS), the

macrophagic myofasciitis syndrome (MMF) and post-vaccination phenomena

were linked with previous exposure to an adjuvant. Furthermore, these

four diseases share a similar complex of signs and symptoms which

further support a common denominator.Thus, we review herein the current

data regarding the role of adjuvants in the pathogenesis of immune

mediated diseases as well as the amassed data regarding each of these

four conditions. Relating to the current knowledge we would like to

suggest to include these comparable conditions under a common syndrome

entitled ASIA, " Autoimmune (Auto-inflammatory) Syndrome Induced by

Adjuvants " .

[Guest guest]

Re: Autoimmune/inflammatory syndrome induced by adjuvants

Posted by: " Hannifin " drlisahannifin@... drlisahannifin

Date: Mon Feb 14, 2011 1:06 pm ((PST))

Fascinating, may I re-post?

- - - -

Yes!

- - - -

Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA):

Old truths and a new syndrome? <http://www.ncbi.nlm.nih.gov/pubmed/21051205>

Meroni PL.

J Autoimmun. 2011 Feb;36(1):1-3. Epub 2010 Nov 3.

There has been considerable interest in the role of environmental

factors and the induction of autoimmunity and the ways by which they

facilitate loss of tolerance. Clearly both genetic and environmental

factors are incriminated, as evidenced by the lack of concordance in

identical twins and the relatively recent identification of the shared

epitope in rheumatoid arthritis. In this issue a new syndrome called

'Asia'-autoimmune/auto-inflammatory syndrome induced by adjuvants has

been proposed. It is an intriguing issue and one that is likely to be

provocative and lead to further biologic and molecular investigations.

'ASIA' - Autoimmune/inflammatory syndrome induced by adjuvants.

<http://www.ncbi.nlm.nih.gov/pubmed/20708902>

Shoenfeld Y, Agmon-Levin N.

J Autoimmun. 2011 Feb;36(1):4-8. Epub 2010 Aug 13.

The role of various environmental factors in the pathogenesis of immune

mediated diseases is well established. Of which, factors entailing an

immune adjuvant activity such as infectious agents, silicone, aluminium

salts and others were associated with defined and non-defined immune

mediated diseases both in animal models and in humans. In recent years,

four conditions: siliconosis, the Gulf war syndrome (GWS), the

macrophagic myofasciitis syndrome (MMF) and post-vaccination phenomena

were linked with previous exposure to an adjuvant. Furthermore, these

four diseases share a similar complex of signs and symptoms which

further support a common denominator.Thus, we review herein the current

data regarding the role of adjuvants in the pathogenesis of immune

mediated diseases as well as the amassed data regarding each of these

four conditions. Relating to the current knowledge we would like to

suggest to include these comparable conditions under a common syndrome

entitled ASIA, " Autoimmune (Auto-inflammatory) Syndrome Induced by

Adjuvants " .