TLR4: Polluted air leads to disease by promoting widespread inflammation

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Polluted Air Leads to Disease by Promoting Widespread Inflammation

ScienceDaily (Apr. 14, 2011) --- Chronic inhalation of polluted air

appears to activate a protein that triggers the release of white blood

cells, setting off events that lead to widespread inflammation,

according to new research in an animal model....

http://www.sciencedaily.com/releases/2011/04/110414131834.htm

url presents link to study

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TLR4 in autism:

Impact of innate immunity in a subset of children with autism spectrum

disorders: a case control study.

<http://www.ncbi.nlm.nih.gov/pubmed/19025588>

Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H.

J Neuroinflammation. 2008 Nov 21;5:52.

see also:

Lipidomics: The Function of Vital Lipids in Embryogenesis Preventing

Autism Spectrum Disorders, Treating Sterile Inflammatory Diatheses with

a Lymphopoietic Central Nervous System Component.

<http://www.ncbi.nlm.nih.gov/pubmed/21490796>

Tallberg T, Dabek J, Hallamaa R, Atroshi F.

J Lipids. 2011;2011:137175. Epub 2010 Dec 20.

Schizophrenia and autism: both shared and disorder-specific pathogenesis

via perinatal inflammation? <http://www.ncbi.nlm.nih.gov/pubmed/21289540>

Meyer U, Feldon J, Dammann O.

Pediatr Res. 2011 May;69(5 Pt 2):26R-33R.

Methionine sulfoximine may improve inflammation in autism, a novel

hypothesized treatment for autism.

<http://www.ncbi.nlm.nih.gov/pubmed/21199736>

Ghanizadeh A.

Arch Med Res. 2010 Nov;41(8):651-2

Cerebrospinal fluid and serum markers of inflammation in autism.

<http://www.ncbi.nlm.nih.gov/pubmed/16139734>

Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A,

Heyes MP.

Pediatr Neurol. 2005 Sep;33(3):195-201.

Innate immunity associated with inflammatory responses and cytokine

production against common dietary proteins in patients with autism

spectrum disorder. <http://www.ncbi.nlm.nih.gov/pubmed/12378124>

Jyonouchi H, Sun S, Itokazu N.

Neuropsychobiology. 2002;46(2):76-84.