urinary organic acids: biochemical and nutritional individuality in autistic children

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at least some are markers of mitochondrial dysfunction:

Noninvasive urinary organic acids test to assess biochemical and

nutritional individuality in autistic children.

<http://www.ncbi.nlm.nih.gov/pubmed/21300048>

Ka?uz.na-Czaplin'ska J.

Clin Biochem. 2011 Feb 12.

OBJECTIVES: Quantitative organic acid testing can give information about

potential problems, especially with energy production, neurotransmitter

metabolism, intestinal dysbiosis and nutritional individuality which is

very important in autistic children. The aim of this study was to find

out potential differences between the levels of organic acids in the

urine of autistic and non-autistic children.

DESIGN AND METHODS: The organic acids in the urine were determined by

capillary gas chromatography/mass spectrometry (GC/MS). All overnight

urine samples were collected from 35 autistic children and 36

neurologically normal children as healthy controls (4-10years).

RESULTS: Significant differences were found between the autistic

children and the control group in organic acids: 2-oxoglutaric,

isocitric, citric, 4-hydroxybenzoic, 4-hydroxyphenylacetic, hippuric,

adipic, suberic (all with p<0.05).

CONCLUSION: Organic acids test can be used to assess an individual need

for nutrient and biochemical abnormalities, especially important for

autistic children.