Prenatal Exposure to Phthalates and Infant Development at Six Months

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Pubmed for

phthalat* AND autism

brings forth 3 cites.

Prenatal Exposure to *Phthalates* and Infant Development at Six Months:

Prospective Mothers and Children's Environmental Health (MOCEH) Study.

<http://www.ncbi.nlm.nih.gov/pubmed/21737372>

Kim Y, Ha EH, Kim EJ, Park H, Ha M, Kim JH, Hong YC, Chang N, Kim BN.

Environ Health Perspect. 2011 Jul 7. [Epub ahead of print]

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F1\

0.1289%2Fehp.1003178

Background: There are increasing concerns over adverse effects of

prenatal phthalate exposure on the neurodevelopment of infants.

Objectives: Our goal was to explore the association between prenatal di

(2-ethylhexyl) phthalate and dibutyl phthalate exposure and the mental

(MDI) and psychomotor (PDI) developmental indices of the Bayley Scales

of Infant Development at six months, as part of the Mothers and

Children's Environmental Health Study. Methods: Between 2006 and 2009,

460 mother/infant pairs from Seoul, Cheonan and Ulsan participated.

Prenatal mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono

(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-n-butyl phthalate (MBP)

were measured in one urine sample acquired from each mother during the

third trimester of pregnancy. Associations with log-transformed

creatinine-corrected phthalate concentrations were estimated using

linear regression models adjusted for potential confounders. Results:

MDI was inversely associated with the natural log concentrations (µg/g

creatinine) of MEHHP (B = -0.97, CI = -1.85 to -0.08) and MEOHP (B =

-0.95, CI = -1.87 to -0.03), and PDI was inversely associated with MEHHP

(B = -1.20, CI = -2.33 to -0.08). In males, MDI was inversely associated

with MEHHP (B = -1.46, CI = -2.70 to -0.22), MEOHP (B = -1.57, CI =

-2.87 to -0.28), and MBP (B = -0.93, CI = -1.82 to -0.05); and PDI was

inversely associated with MEHHP (B = -2.36, CI = -3.94 to -0.79), MEOHP

(B = -2.05, CI = -3.71 to -0.39), and MBP (B = -1.25, CI = -2.40 to

-0.11). No significant linear associations were observed for females.

Conclusions: The results suggest that prenatal exposure to phthalates

may be inversely associated with the MDI and PDI of infants,

particularly males, at six months.