Freeway air pollution linked to brain damage in mice - Alzheimer's autism amyloid

[Guest guest]

http://latimesblogs.latimes.com/greenspace/2011/04/freeway-air-pollution-brain-d\

amage-mice.html

It is well known that air pollution from cars and trucks on Southern

California freeways -- a combination of soot, pavement dust and other

toxic substances -- can cause respiratory disease, heart attacks, cancer

and premature death.

Now, exposure to pollution particles roughly one-thousandth the width of

a human hair has been linked to brain damage in mice, including signs

associated with memory loss and Alzheimer's disease, according to a USC

study in the journal Environmental Health Perspectives....

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Glutamatergic Neurons in Rodent Models Respond to Nanoscale Particulate

Urban Air Pollutants /In Vivo/ and /In Vitro/

<http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F\

10.1289%2Fehp.1002973>

Todd E. , A. , Nahoko Iwata, A. Tanner,

Snyder, Zhi Ning, Winnie Kam, Yu-Tien Hsu, W. Winkler, Jiu-Chiuan

Chen, Nicos A. Petasis, Michel Baudry, Constantinos Sioutas, Caleb E. Finch

EHP Online 07 Apr 2011 | doi:10.1289/ehp.1002973

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see also:

Residential Proximity to Freeways and Autism in the CHARGE study.

<http://www.ncbi.nlm.nih.gov/pubmed/21156395>

Volk HE, Hertz-Picciotto I, Delwiche L, Lurmann F, McConnell R.

Environ Health Perspect. 2010 Dec 13. [

High levels of Alzheimer beta-amyloid precursor protein (APP) in

children with severely autistic behavior and aggression.

<http://www.ncbi.nlm.nih.gov/pubmed/16948926>

Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA, Lahiri DK.

J Child Neurol. 2006 Jun;21(6):444-9.

Peripheral biomarkers in Autism: secreted amyloid precursor

protein-alpha as a probable key player in early diagnosis.

<http://www.ncbi.nlm.nih.gov/pubmed/19079679>

AR, Giunta BN, Obregon D, Nikolic WV, Tian J, Sanberg CD, Sutton

DT, Tan J.

Int J Clin Exp Med. 2008;1(4):338-44. Epub 2008 Oct 15.