Rare gene variants linked to ADHD

[Guest guest]

Rare gene variants linked to ADHD.

<http://www.sciencenews.org/view/generic/id/333158/title/Rare_gene_variants_link\

ed_to_ADHD>

A new study bolsters the idea that many different rare variants, some

found only in single families or individuals, are responsible for ADHD.

What's more, variants of the same genes associated with ADHD have also

been linked to autism spectrum disorders, schizophrenia, bipolar

disorder and intellectual disability.

Rare copy number variation discovery and cross-disorder comparisons

identify risk genes for ADHD. <http://www.ncbi.nlm.nih.gov/pubmed/21832240>

Lionel AC, Crosbie J, Barbosa N, Goodale T, Thiruvahindrapuram B,

Rickaby J, Gazzellone M, Carson AR, Howe JL, Wang Z, Wei J, AF,

R, McPherson R, Fiebig A, e A, Schreiber S, Zwaigenbaum L,

Fernandez BA, W, Arnold PD, Szatmari P, Marshall CR, Schachar R,

Scherer SW.

Sci Transl Med. 2011 Aug 10;3(95):95ra75.

http://stm.sciencemag.org/content/3/95/95ra75.abstract

- - - -

Social responsiveness scale-aided analysis of the clinical impact of

copy number variations in autism.

<http://www.ncbi.nlm.nih.gov/pubmed/21837366>

van Daalen E, Kemner C, Verbeek NE, van der Zwaag B, Dijkhuizen T, Rump

P, Houben R, van 't Slot R, de Jonge MV, Staal WG, Beemer FA, Vorstman

JA, Burbach JP, van Amstel HK, Hochstenbach R, Brilstra EH, Poot M.

Neurogenetics. 2011 Aug 12.

Rare de novo and transmitted copy-number variation in autistic spectrum

disorders. <http://www.ncbi.nlm.nih.gov/pubmed/21658582>

Levy D, Ronemus M, Yamrom B, Lee YH, Leotta A, Kendall J, Marks S,

Lakshmi B, Pai D, Ye K, Buja A, Krieger A, Yoon S, Troge J, Rodgers L,

Iossifov I, Wigler M.

Neuron. 2011 Jun 9;70(5):886-97.