new Jyonouchi: ASD chronic GI symptoms, fluctuation of behavioral symptoms - innate immune abnormalities, monocytes

[Guest guest]

Children with autism spectrum disorders (ASD) who exhibit chronic

gastrointestinal (GI) symptoms and marked fluctuation of behavioral

symptoms exhibit distinct innate immune abnormalities and

transcriptional profiles of peripheral blood (PB) monocytes.

<http://www.ncbi.nlm.nih.gov/pubmed/21803429>

Jyonouchi H, Geng L, Streck DL, Toruner GA.

J Neuroimmunol. 2011 Jul 29. [Epub ahead of print]

http://www.sciencedirect.com/science/article/pii/S0165572811001913

Innate/adaptive immune responses and transcript profiles of peripheral

blood monocytes were studied in ASD children who exhibit fluctuating

behavioral symptoms following infection and other immune insults

(ASD/Inf, N=30). The ASD/Inf children with persistent gastrointestinal

symptoms (ASD/Inf+GI, N=19), revealed less production of proinflammatory

and counter-regulatory cytokines with stimuli of innate immunity and

marked changes in transcript profiles of monocytes as compared to

ASD/no-Inf (N=28) and normal (N=26) controls. This included a 4-5 fold

up-regulation of chemokines (CCL2 and CCL7), consistent with the

production of more CCL2 by ASD/Inf+GI cells. These results indicate

dysregulated innate immune defense in the ASD/Inf+GI children, rendering

them more vulnerable to common microbial infection/dysbiosis and

possibly subsequent behavioral changes.