pdf: Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

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Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric

populations. <http://www.ncbi.nlm.nih.gov/pubmed/22235057>

Tomljenovic L, Shaw C.

Lupus. 2012;21(2):223-30.

http://www.scribd.com/doc/78232562/Mechanisms-of-Aluminum-Adjuvant-Toxicity-and-\

Autoimmunity-in-Pediatric-Populations

Immune challenges during early development, including those

vaccine-induced, can lead to permanent detrimental alterations of the

brain and immune function. Experimental evidence also shows that

simultaneous administration of as little as two to three immune

adjuvants can overcome genetic resistance to autoimmunity. In some

developed countries, by the time children are 4 to 6 years old, they

will have received a total of 126 antigenic compounds along with high

amounts of aluminum (Al) adjuvants through routine vaccinations.

According to the US Food and Drug Administration, safety assessments for

vaccines have often not included appropriate toxicity studies because

vaccines have not been viewed as inherently toxic. Taken together, these

observations raise plausible concerns about the overall safety of

current childhood vaccination programs. When assessing adjuvant toxicity

in children, several key points ought to be considered:

(i) infants and children should not be viewed as " small adults " with

regard to toxicological risk as their unique physiology makes them much

more vulnerable to toxic insults;

(ii) in adult humans Al vaccine adjuvants have been linked to a variety

of serious autoimmune and inflammatory conditions (i.e., " ASIA " ), yet

children are regularly exposed to much higher amounts of Al from

vaccines than adults;

(iii) it is often assumed that peripheral immune responses do not affect

brain function. However, it is now clearly established that there is a

bidirectional neuro-immune cross-talk that plays crucial roles in

immunoregulation as well as brain function. In turn, perturbations of

the neuro-immune axis have been demonstrated in many autoimmune diseases

encompassed in " ASIA " and are thought to be driven by a hyperactive

immune response; and

(iv) the same components of the neuro-immune axis that play key roles in

brain development and immune function are heavily targeted by Al adjuvants.

In summary, research evidence shows that increasing concerns about

current vaccination practices may indeed be warranted. Because children

may be most at risk of vaccine-induced complications, a rigorous

evaluation of the vaccine-related adverse health impacts in the

pediatric population is urgently needed.

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see also:

Do aluminum vaccine adjuvants contribute to the rising prevalence of

autism? <http://www.ncbi.nlm.nih.gov/pubmed/22099159>

Tomljenovic L, Shaw CA.

J Inorg Biochem. 2011 Nov;105(11):1489-99.

http://www.scribd.com/doc/74769917/Do-Aluminum-Vaccine-Adjuvants-Contribute-to-R\

ising-Prevalence-of-Autism