Infant mortality rates regressed against number of vaccine doses routinely given

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open access:

Infant mortality rates regressed against number of vaccine doses

routinely given: is there a biochemical or synergistic toxicity?

<http://www.ncbi.nlm.nih.gov/pubmed/21543527>

NZ, Goldman GS.

Hum Exp Toxicol. 2011 Sep;30(9):1420-8.

pdf here <http://het.sagepub.com/content/30/9/1420.long>

The infant mortality rate (IMR) is one of the most important indicators

of the socio-economic well-being and public health conditions of a

country. The US childhood immunization schedule specifies 26 vaccine

doses for infants aged less than 1 year--the most in the world--yet 33

nations have lower IMRs. Using linear regression, the immunization

schedules of these 34 nations were examined and a correlation

coefficient of r = 0.70 (p < 0.0001) was found between IMRs and the

number of vaccine doses routinely given to infants. Nations were also

grouped into five different vaccine dose ranges: 12-14, 15-17, 18-20,

21-23, and 24-26. The mean IMRs of all nations within each group were

then calculated. Linear regression analysis of unweighted mean IMRs

showed a high statistically significant correlation between increasing

number of vaccine doses and increasing infant mortality rates, with r =

0.992 (p = 0.0009). Using the Tukey-Kramer test, statistically

significant differences in mean IMRs were found between nations giving

12-14 vaccine doses and those giving 21-23, and 24-26 doses. A closer

inspection of correlations between vaccine doses, biochemical or

synergistic toxicity, and IMRs is essential.

see also:

A Positive Association found between Autism Prevalence and Childhood

Vaccination uptake across the U.S. Population.

<http://www.ncbi.nlm.nih.gov/pubmed/21623535>

Delong G.

J Toxicol Environ Health A. 2011 Jan;74(14):903-16.

pdf here <http://tinyurl.com/3p2cd5z>

The reason for the rapid rise of autism in the United States that began

in the 1990s is a mystery. Although individuals probably have a genetic

predisposition to develop autism, researchers suspect that one or more

environmental triggers are also needed. One of those triggers might be

the battery of vaccinations that young children receive. Using

regression analysis and controlling for family income and ethnicity, the

relationship between the proportion of children who received the

recommended vaccines by age 2 years and the prevalence of autism (AUT)

or speech or language impairment (SLI) in each U.S. state from 2001 and

2007 was determined. A positive and statistically significant

relationship was found: The higher the proportion of children receiving

recommended vaccinations, the higher was the prevalence of AUT or SLI. A

1% increase in vaccination was associated with an additional 680

children having AUT or SLI. Neither parental behavior nor access to care

affected the results, since vaccination proportions were not

significantly related (statistically) to any other disability or to the

number of pediatricians in a U.S. state. The results suggest that

although mercury has been removed from many vaccines, other culprits may

link vaccines to autism. Further study into the relationship between

vaccines and autism is warranted.

Do aluminum vaccine adjuvants contribute to the rising prevalence of

autism? <http://www.ncbi.nlm.nih.gov/pubmed/22099159>

Tomljenovic L, Shaw CA.

J Inorg Biochem. 2011 Nov;105(11):1489-99. Epub 2011 Aug 23.

pdf here <http://omsj.org/reports/tomljenovic%202011.pdf>

Autism spectrum disorders (ASD) are serious multisystem developmental

disorders and an urgent global public health concern. Dysfunctional

immunity and impaired brain function are core deficits in ASD. Aluminum

(Al), the most commonly used vaccine adjuvant, is a demonstrated

neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the

potential to induce neuroimmune disorders. When assessing adjuvant

toxicity in children, two key points ought to be considered: (i)

children should not be viewed as " small adults " as their unique

physiology makes them much more vulnerable to toxic insults; and (ii) if

exposure to Al from only few vaccines can lead to cognitive impairment

and autoimmunity in adults, is it unreasonable to question whether the

current pediatric schedules, often containing 18 Al adjuvanted vaccines,

are safe for children? By applying Hill's criteria for establishing

causality between exposure and outcome we investigated whether exposure

to Al from vaccines could be contributing to the rise in ASD prevalence

in the Western world. Our results show that: (i) children from countries

with the highest ASD prevalence appear to have the highest exposure to

Al from vaccines; (ii) the increase in exposure to Al adjuvants

significantly correlates with the increase in ASD prevalence in the

United States observed over the last two decades (Pearson r=0.92,

p<0.0001); and (iii) a significant correlation exists between the

amounts of Al administered to preschool children and the current

prevalence of ASD in seven Western countries, particularly at 3-4 months

of age (Pearson r=0.89-0.94, p=0.0018-0.0248). The application of the

Hill's criteria to these data indicates that the correlation between Al

in vaccines and ASD may be causal. Because children represent a fraction

of the population most at risk for complications following exposure to

Al, a more rigorous evaluation of Al adjuvant safety seems warranted.

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