Guest guest Posted July 20, 2012 Report Share Posted July 20, 2012 BPA replacements appear in household dust. <http://cen.acs.org/articles/90/web/2012/07/BPA-Replacements-Appear-Household-Du\ st.html> Because of concerns about BPA's hormone-disrupting properties, manufacturers have started using alternatives, many of which are also bisphenols and raise similar health concerns. Now researchers have detected two major BPA substitutes in the majority of indoor dust samples from four countries. Children's environmental health: intergenerational equity in action--a civil society perspective. <http://www.ncbi.nlm.nih.gov/pubmed/18991917> Lloyd- M, Sheffield-Brotherton B. Ann N Y Acad Sci. 2008 Oct;1140:190-200. Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age. <http://www.ncbi.nlm.nih.gov/pubmed/19822263> Larsson M, Weiss B, Janson S, Sundell J, Bornehag CG. Neurotoxicology. 2009 Sep;30(5):822-31. Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors. <http://www.ncbi.nlm.nih.gov/pubmed/20100501> Messer A. Physiol Behav. 2010 Jun 1;100(3):245-9. Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia. <http://www.ncbi.nlm.nih.gov/pubmed/18245062> Brown JS Jr. Schizophr Bull. 2009 Jan;35(1):256-78. Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review. <http://www.ncbi.nlm.nih.gov/pubmed/22458970> de Cock M, Maas YG, van de Bor M. Acta Paediatr. 2012 Aug;101(8):811-8. Aim: To provide an overview of studies on perinatal exposure in humans to endocrine disrupting chemicals (EDCs) in relation to autism spectrum (ASD) and attention deficit hyperactivity (ADHD) disorders. Methods: A review of the literature (PubMed) was performed. Exposure-related keywords, including various chemicals, were matched with keywords describing outcome. Animal studies as well as publications not written in English were excluded. In total, 834 titles were retrieved. The final selection included 21 publications. Results: Positive associations were found for ASD in relation to exposure to all chemicals investigated, which included hazardous air pollutants, pesticides and bisphenol A (BPA). Increased risks of ADHD or positive associations were found for exposure to polychlorinated biphenyls (PCBs), dialkyl phosphate (DAP) and chlorpyrifos. BPA, polybrominated diphenylethers (PBDEs) and low molecular weight (LMW) phthalates were positively associated with externalizing behaviour. Five of 17 studies did not find any association between exposure and ADHD. Conclusion: Perinatal exposure to EDCs appears to be associated with the occurrence of ASD as well as ADHD. Disruption of thyroid hormone function and gamma-aminobutyric acid (GABA)ergic mechanisms may offer an explanation for the observed relations; though, conclusive evidence in humans is limited. Quote Link to comment Share on other sites More sharing options...
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