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pollutants amid: Maternal Metabolic Conditions and Risk for Autism and Other Neurodevelopmental Disorders - obesity

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Pollutants are associated with metabolic conditions (references

hereinbelow) thus the findings of Krakowiaket al maybe a further

reflection of pollutants as etiologically significant factors in many

and perhaps most cases of autism and also a further indictment of

so-called risk-management policies enforced to allow " low dose "

exposures to myriad molecules which are profitably patented.

//

Maternal Metabolic Conditions and Risk for Autism and Other

Neurodevelopmental Disorders

* a Krakowiak, et al

Pediatrics peds.2011-2583; published ahead of print April 9, 2012,

doi:10.1542/peds.2011-2583

* Abstract

<http://pediatrics.aappublications.org/content/early/2012/04/04/peds.2011-2583.a\

bstract?sid=857c12f8-cd6d-4898-a87f-610dcf50996e>

* Full Text (PDF)

<http://pediatrics.aappublications.org/content/early/2012/04/04/peds.2011-2583.f\

ull.pdf+html?sid=857c12f8-cd6d-4898-a87f-610dcf50996e>

OBJECTIVE: We examined whether metabolic conditions (MCs) during

pregnancy (diabetes, hypertension, and obesity) are associated with

autism spectrum disorder (ASD), developmental delays (DD), or

impairments in specific domains of development in the offspring....

CONCLUSIONS: Maternal MCs may be broadly associated with

neurodevelopmental problems in children. With obesity rising steadily,

these results appear to raise serious public health concerns.

*/References/*

[just a small sampling]

Relationship between serum concentrations of persistent organic

pollutants and the prevalence of metabolic syndrome among non-diabetic

adults: results from the National Health and Nutrition Examination

Survey 1999-2002. <http://www.ncbi.nlm.nih.gov/pubmed/17624515>

Lee DH, Lee IK, Porta M, Steffes M, s DR Jr.

Diabetologia. 2007 Sep;50(9):1841-51.

Persistent organic pollutants and obesity-related metabolic dysfunction:

focusing on type 2 diabetes. <http://www.ncbi.nlm.nih.gov/pubmed/22323980>

Lee DH.

Epidemiol Health. 2012;34:e2012002.

Obesity and persistent organic pollutants: possible obesogenic effect of

organochlorine pesticides and polychlorinated biphenyls.

<http://www.ncbi.nlm.nih.gov/pubmed/20559302>

Dirinck E, Jorens PG, Covaci A, Geens T, Roosens L, Neels H, Mertens I,

Van Gaal L.

Obesity (Silver Spring). 2011 Apr;19(4):709-14.

Do interactions between gut ecology and environmental chemicals

contribute to obesity and diabetes?

<http://www.ncbi.nlm.nih.gov/pubmed/22042266>

Snedeker SM, Hay AG.

Environ Health Perspect. 2012 Mar;120(3):332-9.

Mitochondrial dysfunction and insulin resistance: the contribution of

dioxin-like substances. <http://www.ncbi.nlm.nih.gov/pubmed/21785739>

Lee HK.

Diabetes Metab J. 2011 Jun;35(3):207-15.

Increase in metabolic syndrome-related hospitalizations in relation to

environmental sources of persistent organic pollutants.

<http://www.ncbi.nlm.nih.gov/pubmed/21556177>

Sergeev AV, Carpenter DO.

Int J Environ Res Public Health. 2011 Mar;8(3):762-76.

Low dose organochlorine pesticides and polychlorinated biphenyls predict

obesity, dyslipidemia, and insulin resistance among people free of

diabetes. <http://www.ncbi.nlm.nih.gov/pubmed/21298090>

Lee DH, Steffes MW, Sjödin A, RS, Needham LL, s DR Jr.

PLoS One. 2011 Jan 26;6(1):e15977.

Association of low-dose exposure to persistent organic pollutants with

global DNA hypomethylation in healthy Koreans.

<http://www.ncbi.nlm.nih.gov/pubmed/20064773>

Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, s DR, Steffes M,

Lee DH.

Environ Health Perspect. 2010 Mar;118(3):370-4.

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