Non-Celiac Wheat Sensitivity : also, Wheat Belly

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Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind

Placebo-Controlled Challenge: Exploring a New Clinical Entity.

<http://www.ncbi.nlm.nih.gov/pubmed/22825366>

Carroccio A, Mansueto P, Iacono G, Soresi M, D'Alcamo A, Cavataio F,

Brusca I, Florena AM, Ambrosiano G, Seidita A, Pirrone G, Rini GB.

Am J Gastroenterol. 2012 Jul 24. doi: 10.1038/ajg.2012.236.

Non-celiac wheat sensitivity (WS) is considered a new clinical entity.

An increasing percentage of the general population avoids gluten

ingestion. However, the real existence of this condition is debated and

specific markers are lacking. Our aim was thus to demonstrate the

existence of WS and define its clinical, serologic, and histological

markers.

We reviewed the clinical charts of all subjects with an irritable bowel

syndrome (IBS)-like presentation who had been diagnosed with WS using a

double-blind placebo-controlled (DBPC) challenge in the years 2001-2011.

One hundred celiac disease (CD) patients and fifty IBS patients served

as controls.

Two hundred and seventy-six patients with WS, as diagnosed by DBPC

challenge, were included. Two groups showing distinct clinical

characteristics were identified: WS alone (group 1) and WS associated

with multiple food hypersensitivity (group 2). As a whole group, the WS

patients showed a higher frequency of anemia, weight loss, self-reported

wheat intolerance, coexistent atopy, and food allergy in infancy than

the IBS controls. There was also a higher frequency of positive serum

assays for IgG/IgA anti-gliadin and cytometric basophil activation in

" in vitro " assay. The main histology characteristic of WS patients was

eosinophil infiltration of the duodenal and colon mucosa. Patients with

WS alone were characterized by clinical features very similar to those

found in CD patients. Patients with multiple food sensitivity were

characterized by clinical features similar to those found in allergic

patients.

Our data confirm the existence of non-celiac WS as a distinct clinical

condition. We also suggest the existence of two distinct populations of

subjects with WS: one with characteristics more similar to CD and the

other with characteristics pointing to food allergy.

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see also:

I perused Wheat Belly (1) and found its central hypothesis compelling,

supported by numerous peer-reviewed citations, and augmented by the

author's clinical observations.

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1. */Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path

Back to Health/*

, M.D., 2011

http://www.amazon.com/Wheat-Belly-Lose-Weight-Health/dp/1609611543/

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see Parent Ratings by ARI, special diets section/*

http://www.autism.com/pdf/providers/ParentRatings2009.pdf