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ot? Methylphenidate induces dopamine neuron loss and activation of microglia in the basal ganglia of mice

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Methylphenidate exposure induces dopamine neuron loss and activation of

microglia in the basal ganglia of mice.

<http://www.ncbi.nlm.nih.gov/pubmed/22470460>

Sadasivan S, Pond BB, Pani AK, Qu C, Jiao Y, Smeyne RJ.

PLoS One. 2012;7(3):e33693. Epub 2012 Mar 21.

" Collectively, our results suggest that chronic MPH usage in mice */at

doses spanning the therapeutic range in humans/*, especially at

prolonged higher doses, has long-term neurodegenerative consequences. "

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