Guest guest Posted February 9, 2008 Report Share Posted February 9, 2008 Yes, I follow his work. He did the research on Nutra Sweet, and found it to be a neuro toxin, however big business won, and it was given the O.k. by the FDA. ; Autism-Immune@...: sjsmith@...: Sat, 9 Feb 2008 11:08:52 -0500Subject: Blaylock item Anyone familiar with Dr Blaylock?Vaccines, Depression and Neurodegeneration After Age 50: Another Reasonto Avoid the Recommended Vaccines.By L. Blaylock, M.D., CCN <http://v.mercola.com/blogs/public_blog/How-Vaccines-Can-Damage-Your-Brain-49839\ ..aspx>It has been estimated that 14.8 million Americans suffer from majordepressive disorder and of this number 6 million are elderly. If weinclude anxiety disorders, which commonly accompany depression, thenumber jumps to 40 million adults. At a cost of $44 billon dollars ayear just for care of the seniors, this impacts the national budget aswell. Depression later in life tends to last longer and be more severethan at younger ages. It is also associated with a high rate ofsuicide.Previously, it was thought that major depression was secondary to adeficiency in certain neurotransmitters in the brain, particularly themonoamines, which include serotonin, norepinephrine and dopamine. Whilealterations in these important mood-related neurotransmitters is foundwith major depression, growing evidence indicates that the primaryculprit is low-grade, chronic brain inflammation. In addition, we nowknow that inflammatory cytokines can lower serotonin significantly andfor long periods by a number of different mechanisms.Researchers have also discovered that most people with major depressivedisease (MDD) have higher levels of the neurotransmitter glutamate intheir spinal fluid (CSF) and blood plasma. This is the same glutamatefound as a food additive-for example, MSG (monosodium glutamate),hydrolyzed proteins, calcium or sodium casienate, soy protein isolate,vegetable protein concentrate or isolate, etc. Much of the freeglutamate in the brain of depressed people comes from within, that isit escapes from special cells within the brain itself (microglia andastrocytes). Free glutamate, that is, existing outside the neurons, isvery toxic to brain connections and brain cells themselves -- mainly bya process called excitotoxicity.This connection between high brain glutamate levels and majordepression was discovered quite by accident, when researchers observedthat the anesthetic drug ketamine could relieve depression for aprolonged period. Ketamine is a powerful blocking drug for a class ofglutamate receptors (NMDA receptors).For quite some time it was known that depression could cause a loss ofneurons in the hippocampus of the brain-the area most important forrecent memory (declarative memory or working memory), the form ofmemory most affected in Alzheimer's disease. This shrinkage of thebrain usually occurred with long-term depression, yet it was shown,using sophisticated testing, that even without brain shrinkage, memorycould be adversely affected. Some antidepressants could not onlyreverse the memory loss but could reverse the shrinkage as well.The implication was that the elevated brain glutamate, viaexcitotoxicity, was destroying brain connections and later killingbrain cells in the hippocampus and that the antidepressants werelowering brain glutamate levels. Subsequent studies have confirmed thatdrugs that block excitotoxicity also reduce depression and that someantidepressants reduce brain glutamate levels.The Link Between Elevated Brain Glutamate and InflammationA tremendous amount of research has now demonstrated the link betweenchronic low-level brain inflammation, elevated brain glutamate levelsand major depression. We know that as we age, the level of inflammatoryimmune cytokines increase (such as interleukin-1ß (IL-1), IL-6 andTNF-a). That is, the level of inflammation in our body increases, withhigh levels being seen at the extremes of life -- the 80s and 90s.This progressive elevation in the body's inflammation increases ourrisk of a number of inflammation-linked diseases, such as cancer,arthritis, muscle weakness, fatigue, sleep disturbances, memory lossand confusion. People with Alzheimer's and Parkinson's disease haveeven higher levels of these inflammatory cytokines -- much higher.When inflammatory chemicals are elevated in the brain it makes braincells more vulnerable to a number of toxins, many of which are in theenvironment. One study demonstrated, using a series of sophisticatedtechniques, that if brain cells were exposed to low levels of apesticide there was little toxicity seen and that if you exposed thesesame brain cells to an immune stimulant alone, little damage occurred.But if you first exposed the brain cells to the immune stimulant, thesame low dose of pesticide could destroy a great number of brain cells.The importance of this observation was that the vaccine made the braincells hypersensitive to the toxin so that even in concentrations thatnormally would do not cause harm, could wiped out most of the neurons.One of the strongest connections between an environmental toxin(pesticides) and a neurological disorder is with Parkinson's disease.The reason it is more common in the elderly is that they have thehighest levels of inflammatory cytokines. This also explains the highincidence of Alzheimer's disease, which reaches incidences of 50% afterage 80.The link depression was also by accident. Doctors using immunecytokines to treat patients with cancer or hepatitis found that onethird of the patients developed major depressive illness within days ofthe treatment and that it resolved only when the treatment wasterminated. Other studies, in which inflammatory cytokine levels weremeasured in people with major depressive illness, also found most hadhigh levels of these inflammatory chemicals.To their surprise, they found that many of the antidepressantmedications commonly used lowered inflammatory cytokines levels andthat patients who failed to respond had the highest level of thecytokines.So, how is this linked to excitotoxicity? Neuroscientists have knownfor some time that inflammatory cytokines cause the brain to releasehigher levels of glutamate -- the more intense the inflammation, thehigher the brain glutamate level. The highest levels are found in theprefrontal lobes and limbic system, the areas most related to moodcontrol. MSG also increases brain inflammation.Vaccination and Brain InflammationA great number of studies have shown that when you vaccinate an animal,the body's inflammatory cytokines not only increase dramatically, butso do the brain's inflammatory chemicals. The brain has its own immunesystem that is intimately connected to the body's immune system. Themain immune cell in the brain is called a microglia. Normally, thesebrain cells are lying throughout the brain in a resting state (calledramified). Once activated, they can move around, traveling betweenbrain cells like amoeba (called amoeboid microglia).In the resting state, they release chemicals that support the growthand protection of brain cells and their connections (dendrites andsynapses). But when activated, they secrete a number of very harmfulchemicals, including inflammatory cytokines, chemokines, complement,free radicals, lipid peroxidation products, and two excitotoxins --glutamate and quinolinic acid.In essence, these brain immune cells are out to kill invaders, sincethe body's immune system sent an emergency message that an invasion hadoccurred. With most infections, this phase of activation last no morethan a few days to two weeks, during which time the immune systemsuccessfully kills off the invaders. Once that is accomplished, theimmune system shuts down to allow things to cool off and the brain torepair what damage was done by its own immune system.What researchers knew was that during this period of activation, peoplegenerally feel bad and that what they experience closely resemblesdepression -- a condition called " sickness behavior " . Most of us haveexperience this when suffering from a viral illness -- such things asrestlessness, irritability, a need to get away from people, troublesleeping, fatigue and difficulty thinking.Studies have shown that there are two phases to this " sicknessbehavior " ; one in which we have the flu-like symptoms and a later onsetof depression-like symptoms that can last awhile. They have also shownthat all of these symptoms are due to high levels of inflammatorycytokines in the brain, which come from activated microglia.A number of studies have also shown that after age 50, people haveexaggerated and prolonged " sickness behavior " , much more so thanyounger people. This is one of the reasons why many elderly hang ontoflu symptoms for months after exposure.There is also another immune phenomenon that plays a major role invaccine-related brain injury. Researchers discovered that when youvaccinate an animal, the brain microglia immune cells turn on partially(called priming), that is, they are in a state of high readiness. Ifthe immune system is activated again soon after (days, weeks tomonths), these microglia explode into action secreting levels of theirdestructive chemicals far higher than normal. This overreaction can bevery destructive and make you feel very depressed.Stimulating the immune system with a vaccine is far different thancontracting an infectious illness naturally. Vaccines are made of twocomponents -- the agent you wish to vaccinate against -- for example,the measles virus; and an immune system booster called an immuneadjuvant. These adjuvants are composed of such things as aluminumcompounds, MSG, lipid compounds and even mercury. Their job is to makethe immune system react as intensely as possible and for as long aspossible.Studies have shown that these adjuvants, from a single vaccine, cancause immune overactivation for as long as two years. This means thatthe brain microglia remain active as well, continuously pouring outdestructive chemicals. In fact, one study found that a single injectionof an immune activating substance could cause brain immuneoveractivation for over a year. This is very destructive.Flu Vaccines and An Expanding Vaccine Schedule for the ElderlyPublic health authorities and physician societies are in an all outcampaign to have every elderly person vaccinated every year with theflu vaccine as well as a growing number of newer vaccines. When I waspracticing neurosurgery, the hospitals had an automatic written orderon all older patients' charts mandating a flu vaccine, unless it wascountermanded by the physician, which I always did. Now, they aregiving the shots in malls, tents and every available site they canmuster. And worse still, using lies and scare tactics to frighten theelderly onto getting the shots (such as the bold lie of 36,000 elderlydying of the flu every year).As you age your immune system, including that special immune system inyour brain, releases significantly more inflammatory immune cytokinesthan when you were younger. This serves to prime the microglia, asdiscussed. So, when you get your first flu shot your microgliaoverreact and does so for a very long period -- perhaps years. Manyelderly report that the flu shot gave them the flu. Proponents ofvaccines, retort with a condescending laugh, that it is impossiblebecause the flu vaccine contains killed flu viruses. In truth, whatthese people are reporting is a prolonged, intense " sickness behavior " response to the vaccine. To the body, it is worse than getting the flu.Remember, no one is recording the number of elderly who die aftergetting the flu shot, especially if they die months later, which canhappen with sickness behavior, especially if they have a preexistingchronic illness or are infirm.Here is the shocking truth. With the elderly already having increasedinflammatory cytokine levels both systemically and in their brain,stimulating these primed microglia so that a chronic overstimulation ofthe brain's immune system is triggered, will not only increase theirrisk of developing one of the neurodegenerative diseases, but will alsosubstantially increase their risk of developing major depression.Remember, this also increases their risk of suicide and even homicidedramatically.Anxiety is a major problem with depression, and vaccinations willgreatly worsen the condition. In fact, vaccination, especially multiplevaccinations, will maintain the brain in a state of inflammation thatwill be self-perpetuating, because the excess release of glutamate inthe brain, as well as glutamate in the diet, will further enhancemicroglial activation and excitotoxicity.Those who are prone to developing one of the neurodegenerativediseases, such as Alzheimer's disease or Parkinson's disease will be ata drastically increased risk as we have seen experimentally when evenanimals exposed to subtoxic concentrations of environmental toxins andvaccinated develop neurologic worsening.Most people use pesticides in their home and studies have shown thatthe concentrations in homes are sufficient to trigger Parkinson'sdisease in susceptible people. Vaccinations, as these studies haveshown, will greatly increase risk. Most doctors are completely unawareof this important research.You must keep in mind that " health authorities " urge the elderly to getthe flu vaccine each and every year. This will keep the microglia in aprimed and even activated state continuously. Recently, neurologistsannounced that the incidence of neurodegenerative disease had beengrossly underestimated and that neurological diseases of aging wereincreasing at a frightening rate. They have no explanation. Over thelast three decades the number of elderly receiving yearly flu vaccineshas risen from 20% before 1980 to over 60% today.If this were not depressing enough, now the public health authoritiesand medical specialty societies are adding a whole new set of vaccinesfor those above 50 years of age, including the pneumococcal andmeningiococcal vaccines. What is being completely ignored by thepromoters of these vaccines is the effect of multiple doses of immuneadjuvant that accompany each of these vaccines.Lets, say you see your doctor and he talks you into getting the fluvaccine, the pneumococcal and meningiococcal vaccine all during thesame office visit. That way, he can save you extra office visits. Whatyour doctor ignores is that he is giving you three doses of powerfulimmune adjuvant all in one sitting, which means that your body andbrain are assaulted by a massive dose of powerful immune activators,which have been proven to activate the brain's immune system todangerous levels, even when given as a single dose. Proof of thismechanism exists not only in animal studies, but in humans as well.Mercury and AluminumThere are other ways that vaccines can cause havoc in the brain. Mostvaccines contain aluminum compounds. A multitude of studies have shownthat aluminum, especially if combined with fluoride, is a powerfulbrain toxin and that it accumulates in the brain. With each vaccineinjection, a dose of aluminum is given. These yearly aluminuminoculations accumulate not only at the site of the injection, buttravel to the brain, where it enters neurons and glial cells(astrocytes and microglia). A number of studies have shown thataluminum can activate microglia and do so for long periods. This meansthat the aluminum in your vaccination is priming your microglia tooverreact. The next vaccine acts to trigger the enhanced inflammatoryreaction and release of the excitotoxins, glutamate and quinolinicacid.You must also appreciate that any infection, stroke, head injury orother toxin exposure will also magnify this inflammatory brain reactioninitially triggered by your vaccines. Studies have now indicated thatthe more one's immune system is activated the more like he or she willsuffer from one of the neurodegenerative diseases.Mercury is also a powerful activator of brain microglia and can do soin extremely low concentrations-in nanomolar amounts. Because of itsnumerous reactions with sulfhydral compounds in the body (which areubiquitous), mercury can poison a number of enzymes both systemicallyand in the brain. Of special concern is the ability of mercury,especially ethylmercury (the kind found in vaccines called thimerosal)to inhibit the regulation of brain glutamate levels. (It does this byinhibiting the glutamate transfer proteins that control the removal ofglutamate from outside the neuron, where it does its harm.)In essence, mercury, in the concentrations being injected withvaccines, triggers excitotoxicity, increases brain free radicals andlipid peroxidation products, inhibits critical brain enzymes, inhibitsantioxidant enzymes and impairs DNA repair ability. The flu vaccinecontains enough mercury to do all of these things. You must keep inmind that each flu vaccine adds to the mercury supplied by your lastvaccine, that is, it is progressively accumulating in your brain.In addition, the aluminum in the vaccines also primes microglia andwhen combined with mercury is infinitively more toxic to the brain.Now, if this is not enough, we also have to consider the contaminationof vaccines with foreign viruses and viral components. Studies haveshown that this is not a rare occurrence, with up to 60% of vaccinesbeing contaminated in one study of several major manufactured vaccines.When confronted with this fact, vaccine proponents just shrug theirshoulders and say -- " We don't think these things are harmful. " Yet, the studies say otherwise. It has been found that insertion ofviral fragments, not even the whole virus, is sufficient to trigger thebrain's microglial system and subsequent excitotoxicity, leading toprogressive brain degeneration. This is accepted to be the mechanism bywhich the HIV virus causes dementia in a great number of AIDS victims.Fragments of the virus (gp140 and Tat) are engulfed by the microgliaand this triggers chronic brain inflammation and excitotoxicity. Theherpes virus and measles virus can do the same thing.Danger of Live Virus VaccinesA number of studies have shown that live viruses used in vaccines canenter the brain and reside there for a lifetime. One such study, inwhich autopsied elderly were examined for the presence of the measlesvirus, found that 20% of the brains had live measles viruses and 45% ofother organs were infected. These viruses were highly mutated, meaningthat they could be just as potent as other measles viruses, but couldbe even more virulent. Worse, is that in most cases they cause asmoldering destruction of tissues without the obvious symptoms ofinfection, which has been shown in a number of studies.Live virus vaccines are made using a process to attenuate thepathogenic or disease-causing virus by passing it through a series ofcultures. The problem is that the reverse can also happen within thebody. A number of studies have shown that when we produce free radicalsin our body (and we produce tons of such radicals over a lifetime), itmutates the viruses residing in our tissues. This is what was found inthe autopsy study I referred to above.Likewise, these viruses can trigger brain inflammation anddegeneration, which has been shown in a number of studies-that is,there exist a chronic degeneration of the brain over years or decades.Because it is so far separated from the time of the original vaccine,physicians just attribute it to old age or heredity, anything but thevaccines.Virologists are also concerned that such mutated live viruses can alsoinfect other people, leading to outbreaks of disease totallyunsuspected by health authorities.ConclusionCurrent recommendations by the CDC for adult vaccinations include atotal of 14 separate inoculations with infectious agents and powerfulimmune adjuvants. To be fair, some of these are for special medicalrisks and conditions, such as high-risk behaviors, illegal drug use andHIV infected individuals. If we eliminate these, women will be exposedto 10 inoculations and men 7, should they follow CDC guidelines, whichdoctors follow.According to CDC recommendations, multiple vaccinations for a singledisease are separated by no more than 4 weeks, which is close enoughtogether to produce priming and subsequent hyperactivation of brainmicroglia. We have seen that this can trigger a smoldering process ofbrain inflammation and excitotoxicity that can not only result indepression, anxiety and high suicide rates, but can increase one's riskof developing one of the neurodegenerative diseases as well.We have also seen that in many cases a person will be injected withseveral vaccines during a single office visit and that this means theirbody is exposed to a very large dose of immune adjuvant. Compellingstudies, using many animal species as well as humans, have shown thatthis overactivates brain inflammatory mechanism that can last foryears.In addition, several additives to vaccines, such as mercury andaluminum, are powerful brain toxins that are known to accumulate in thebrain over years and can trigger brain inflammatory/excitotoxicmechanisms. Vaccine contaminants, such as bacteria, mycoplasma andviral fragments can also produce prolonged brain inflammation andneurodegeneration.Because the elderly already have high levels of inflammatory cytokines,they are at a special risk. The very young (babies and small children)are at a high risk because their brains are undergoing the most rapiddevelopment at the very time they receive the greatest number ofvaccinations -- the first two years of life. In fact, they receive 22vaccines during the first year of life, one of which contains a fullpediatric dose of mercury. Like adults, they receive many inoculations(up to 9 inoculations) in one office visit. This is insane and in myestimation, criminal.Nasal flu vaccines are even worse, because they introduce a live virusinto the nasal passages, which can then travel along the olfactorynerves, which leads to the very part of the brain first and mostseverely affected by Alzheimer's disease. A number of studies haveshown that viruses and bacteria can pass along this route to the brain.In fact, in one study scientists sprayed a bacterium into the nose ofmice and observed a rapid development of Alzheimer's type plaques inthe mouse's brain.So, what should older people do? First, studies have shown that theprimary cause of immune deficiency in the elderly is purely dietary.The carotenoids, such as beta-carotene, alpha-carotene, canthaxanthin,lutein and lycopene significantly enhance the immunity of the elderly.Zinc, magnesium and selenium are also essential. One should also avoidomega-6 oils (the vegetable oils-corn, safflower, sunflower, canola,soybean and peanut oils), since they greatly enhance inflammation anddepress immunity. The EPA component of fish oils (omega-3 oils) is alsoa powerful immune suppressant. DHA is not. A healthy immune systemmeans that you can fight infections efficiently and rapidly.Regular exercise, such as brisk walking or weight exercises three tofive times a week also boost immunity, while extreme exercisesuppresses immunity. Sugar and refined carbohydrates also suppressimmunity and inflame the brain. Exercise protects the brain from agingeffects and from degeneration.Adequate sleep is also vital to both brain health and good immunefunction. Pubic health officials and spokesmen for the major medicalsocieties are lying to the public concerning vaccine safety. We nowpossess sufficient information from a great number of studies to haltthis disastrous vaccine policy. We are facing a medial disaster in thiscountry, which is already well on its way.1. McGeer PL and McGeer EG. Local neuroinflammation and progression ofAlzheimer's disease. J Neurovirology 202; 8: 529-538.2. Tavares RG, et al. Quinolinic acid stimulates synaptosomal glutamaterelease and inhibits glutamate uptake into astrocytes. Neurochem Int2002; 40: 621-627.3. Eastman CL, et al. Increased brain quinolinic acid production inmice infected with a neurotropic measles virus. Exp Neurol 1994; 125;119-124.4. Glass JD and Wesselingh SL. Microglia in HIV-associated neurologicaldiseases. Microsc Res Tech 2001; 54: 95-105.5. Turowski RC and Troozzi PL. Central Nervous System toxicities ofcytokine therapy: In: Plotnikoff NP, et al, Eds. Cytokines, Stress andImmunity. Boca Raton, CRC Pres, 1998, pp 93-114.6. Mrak RE, et al. Glail cytokines and Alzheimer's disease: Review andpathogenic implications. Human Pathol 1995; 26: 816-823.7. Klatschmidt C, et al. Stimulation of inotropic glutamate receptorsactivates transcription factor NFkB in primary neurons. Proc Nat AcadSci USA 1995; 92: 9618-9622.8. Gao HM, et al Distinct role for microglia in rotenone-induceddegeneration of dopaminergic neurons. J Neurosci 2002; 22: 782-790.9. Dyatlov VA et al. neonatal lead exposure potentates sicknessbehavior by Listeria monocytogenes infection in mice. Brain Behav Immun2002; 16: 477-492.10. Nakai Y, et al. Apoptosis and microglial activation in influenzaencephalopathy. Acta Neuropath (Berl) 2003; 105: 233-239.11. T et al. NMDA-receptor antagonist prevents measlesvirus-induced neurodegeneration. Eur J Neurosci 1991; 3: 66-71.12. Conner TJ, et al. Depression stress immunological activation: therole of cytokines in depressive disorders. Life Sciences 1998; 62:583-606.13. Renault PF, et al. Psychiatric complications of long-termineterferon-alpha therapy. Arch Internal Medicine 1987; 147: 1577-1580.14. F et al. Neuropsychiatric manifestations of human leukocyteinterferon therapy in patients with cancer. JAMA 1984; 252: 938-941.15. Broderick PA, et al. Interleukin-1a alters hippocampal andnorepinephrine release during open field behavior in Sprague-Dawleyanimals: differences from the Fawn-Hooded animal model of depression.Prog Neuropsychopharmacol Biology 2002; 26: 1355-1372.16. Katayama Y, et al. Detection of measles virus nucleoprotein mRNA inautopsied brain tissues. J General Virology 1995; 76: 3201-3204.17. Nicolson GL et al. High frequency of systemic mycoplasma infectionsin Gulf War Veterans and civilians with amyotrophic lateral sclerosis.J Clin Sci 2002; 9: 525-529.18. Blaylock RL. Interaction of cytokines, excitotoxins, and reactivenitrogen and oxygen species in autism spectrum disorders. JANA 2003; 6:21-35.19. Blaylock RL. Central role of excitotoxicity in autism. JANA 2003;6: 7-19.20. Blaylock RL. Food additive excitotoxins and degenerative braindisorders. Medical Sentinel 1999; 4: 212-215.21. Blaylock RL. Chronic microglial activation and excitotoxicitysecondary to excessive immune stimulation: Possible factors in Gulf WarSyndrome and Autism. J Amer Phys Surg 2004; 9: 46-51.22. Pilc A, et al. Mood disorders: regulation by metabotropic glutamatereceptors. Biochem Pharmacol 2007; (Epub ahead of print)23. Palucha A, Pilc A. The involvement of glutamate in thepathophysiology of depression. 2005; 18: 262-268.24. IA, Skolnick P. Glutamate and depression: clinical andpreclinical studies. Ann NY Acad Sci 2003; 1003: 250-272.25. Pittenger C, et al. The NMDA receptor as a therapeutic target inmajor depressive disorder. CNS Neurol Disorders Drug Targets 2007; 6:101-115.26. Magaki S et al. Increased production of inflammatory cytokines inmild cognitive impairment. Exp Gerontol 2007; 42: 233-240.27. Gao H-M et al. Synergistic dopaminergic neurotoxicity if thepesticide rotenone and inflammogen lipopolysacchride: relevance to theetiology of Parkinson's disease. J Neurosciences 2003; 23: 1228-1236.28. Holmes C et al. Systemic infection, interleukin 1ß, and cognitivedecline. J Neurol Neurosurgery Psychiatry 2003; 74: 788-789.29. Godbout JP et al. Exaggerated neuroinflammation and sicknessbehavior in aged mice after activation of the peripheral innate immunesystem. The FASEB J 2005; 19: 1329-1331.30. VH et al. The impact of infection on the progression ofneurodegenerative disease. Nature Rev Neuroscience 2003;4: 103-112.31. Feiring B et al. Persisting responses indicating long-termprotection after booster dose with meningococcal group B outer membranevesicle vaccine. Clin Vaccine Immunology 2006; 13: 790-796.32. Vaccine Excepients and Media Summery Center for Disease Control andPrevention. (also the source for recommended vaccines for adults andchildren). 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Guest guest Posted February 9, 2008 Report Share Posted February 9, 2008 Me, too. Cheryl On Feb 9, 2008, at 8:42 AM, LINDA A wrote: > > Yes, I follow his work. He did the research on Nutra Sweet, and > found it to be a neuro toxin, however big business won, and it was > given the O.k. by the FDA. > > ; Autism- > Immune@...:sjsmith@...: Sat, 9 Feb > 2008 11:08:52 -0500Subject: Blaylock item > > Anyone familiar with Dr Blaylock?Vaccines, Depression and > Neurodegeneration After Age 50: Another Reasonto Avoid the > Recommended Vaccines.By L. Blaylock, M.D., CCN <http:// > v.mercola.com/blogs/public_blog/How-Vaccines-Can-Damage-Your- > Brain-49839.aspx>It has been estimated that 14.8 million Americans > suffer from majordepressive disorder and of this number 6 million > are elderly. If weinclude anxiety disorders, which commonly > accompany depression, thenumber jumps to 40 million adults. At a > cost of $44 billon dollars ayear just for care of the seniors, this > impacts the national budget aswell. Depression later in life tends > to last longer and be more severethan at younger ages. It is also > associated with a high rate ofsuicide.Previously, it was thought > that major depression was secondary to adeficiency in certain > neurotransmitters in the brain, particularly themonoamines, which > include serotonin, norepinephrine and dopamine. Whilealterations in > these important mood-related neurotransmitters is foundwith major > depression, growing evidence indicates that the primaryculprit is > low-grade, chronic brain inflammation. In addition, we nowknow that > inflammatory cytokines can lower serotonin significantly andfor > long periods by a number of different mechanisms.Researchers have > also discovered that most people with major depressivedisease (MDD) > have higher levels of the neurotransmitter glutamate intheir spinal > fluid (CSF) and blood plasma. This is the same glutamatefound as a > food additive-for example, MSG (monosodium glutamate),hydrolyzed > proteins, calcium or sodium casienate, soy protein > isolate,vegetable protein concentrate or isolate, etc. Much of the > freeglutamate in the brain of depressed people comes from within, > that isit escapes from special cells within the brain itself > (microglia andastrocytes). Free glutamate, that is, existing > outside the neurons, isvery toxic to brain connections and brain > cells themselves -- mainly bya process called excitotoxicity.This > connection between high brain glutamate levels and majordepression > was discovered quite by accident, when researchers observedthat the > anesthetic drug ketamine could relieve depression for aprolonged > period. Ketamine is a powerful blocking drug for a class > ofglutamate receptors (NMDA receptors).For quite some time it was > known that depression could cause a loss ofneurons in the > hippocampus of the brain-the area most important forrecent memory > (declarative memory or working memory), the form ofmemory most > affected in Alzheimer's disease. This shrinkage of thebrain usually > occurred with long-term depression, yet it was shown,using > sophisticated testing, that even without brain shrinkage, > memorycould be adversely affected. Some antidepressants could not > onlyreverse the memory loss but could reverse the shrinkage as > well.The implication was that the elevated brain glutamate, > viaexcitotoxicity, was destroying brain connections and later > killingbrain cells in the hippocampus and that the antidepressants > werelowering brain glutamate levels. Subsequent studies have > confirmed thatdrugs that block excitotoxicity also reduce > depression and that someantidepressants reduce brain glutamate > levels.The Link Between Elevated Brain Glutamate and InflammationA > tremendous amount of research has now demonstrated the link > betweenchronic low-level brain inflammation, elevated brain > glutamate levelsand major depression. We know that as we age, the > level of inflammatoryimmune cytokines increase (such as > interleukin-1ß (IL-1), IL-6 andTNF-a). That is, the level of > inflammation in our body increases, withhigh levels being seen at > the extremes of life -- the 80s and 90s.This progressive elevation > in the body's inflammation increases ourrisk of a number of > inflammation-linked diseases, such as cancer,arthritis, muscle > weakness, fatigue, sleep disturbances, memory lossand confusion. > People with Alzheimer's and Parkinson's disease haveeven higher > levels of these inflammatory cytokines -- much higher.When > inflammatory chemicals are elevated in the brain it makes > braincells more vulnerable to a number of toxins, many of which are > in theenvironment. One study demonstrated, using a series of > sophisticatedtechniques, that if brain cells were exposed to low > levels of apesticide there was little toxicity seen and that if you > exposed thesesame brain cells to an immune stimulant alone, little > damage occurred.But if you first exposed the brain cells to the > immune stimulant, thesame low dose of pesticide could destroy a > great number of brain cells.The importance of this observation was > that the vaccine made the braincells hypersensitive to the toxin so > that even in concentrations thatnormally would do not cause harm, > could wiped out most of the neurons.One of the strongest > connections between an environmental toxin(pesticides) and a > neurological disorder is with Parkinson's disease.The reason it is > more common in the elderly is that they have thehighest levels of > inflammatory cytokines. This also explains the highincidence of > Alzheimer's disease, which reaches incidences of 50% afterage > 80.The link depression was also by accident. Doctors using > immunecytokines to treat patients with cancer or hepatitis found > that onethird of the patients developed major depressive illness > within days ofthe treatment and that it resolved only when the > treatment wasterminated. Other studies, in which inflammatory > cytokine levels weremeasured in people with major depressive > illness, also found most hadhigh levels of these inflammatory > chemicals.To their surprise, they found that many of the > antidepressantmedications commonly used lowered inflammatory > cytokines levels andthat patients who failed to respond had the > highest level of thecytokines.So, how is this linked to > excitotoxicity? Neuroscientists have knownfor some time that > inflammatory cytokines cause the brain to releasehigher levels of > glutamate -- the more intense the inflammation, thehigher the brain > glutamate level. The highest levels are found in theprefrontal > lobes and limbic system, the areas most related to moodcontrol. MSG > also increases brain inflammation.Vaccination and Brain > InflammationA great number of studies have shown that when you > vaccinate an animal,the body's inflammatory cytokines not only > increase dramatically, butso do the brain's inflammatory chemicals. > The brain has its own immunesystem that is intimately connected to > the body's immune system. Themain immune cell in the brain is > called a microglia. Normally, thesebrain cells are lying throughout > the brain in a resting state (calledramified). Once activated, they > can move around, traveling betweenbrain cells like amoeba (called > amoeboid microglia).In the resting state, they release chemicals > that support the growthand protection of brain cells and their > connections (dendrites andsynapses). But when activated, they > secrete a number of very harmfulchemicals, including inflammatory > cytokines, chemokines, complement,free radicals, lipid peroxidation > products, and two excitotoxins --glutamate and quinolinic acid.In > essence, these brain immune cells are out to kill invaders, > sincethe body's immune system sent an emergency message that an > invasion hadoccurred. With most infections, this phase of > activation last no morethan a few days to two weeks, during which > time the immune systemsuccessfully kills off the invaders. Once > that is accomplished, theimmune system shuts down to allow things > to cool off and the brain torepair what damage was done by its own > immune system.What researchers knew was that during this period of > activation, peoplegenerally feel bad and that what they experience > closely resemblesdepression -- a condition called " sickness > behavior " . Most of us haveexperience this when suffering from a > viral illness -- such things asrestlessness, irritability, a need > to get away from people, troublesleeping, fatigue and difficulty > thinking.Studies have shown that there are two phases to this > " sicknessbehavior " ; one in which we have the flu-like symptoms and > a later onsetof depression-like symptoms that can last awhile. They > have also shownthat all of these symptoms are due to high levels of > inflammatorycytokines in the brain, which come from activated > microglia.A number of studies have also shown that after age 50, > people haveexaggerated and prolonged " sickness behavior " , much more > so thanyounger people. This is one of the reasons why many elderly > hang ontoflu symptoms for months after exposure.There is also > another immune phenomenon that plays a major role invaccine-related > brain injury. Researchers discovered that when youvaccinate an > animal, the brain microglia immune cells turn on partially(called > priming), that is, they are in a state of high readiness. Ifthe > immune system is activated again soon after (days, weeks tomonths), > these microglia explode into action secreting levels of > theirdestructive chemicals far higher than normal. This > overreaction can bevery destructive and make you feel very > depressed.Stimulating the immune system with a vaccine is far > different thancontracting an infectious illness naturally. Vaccines > are made of twocomponents -- the agent you wish to vaccinate > against -- for example,the measles virus; and an immune system > booster called an immuneadjuvant. These adjuvants are composed of > such things as aluminumcompounds, MSG, lipid compounds and even > mercury. Their job is to makethe immune system react as intensely > as possible and for as long aspossible.Studies have shown that > these adjuvants, from a single vaccine, cancause immune > overactivation for as long as two years. This means thatthe brain > microglia remain active as well, continuously pouring > outdestructive chemicals. In fact, one study found that a single > injectionof an immune activating substance could cause brain > immuneoveractivation for over a year. This is very destructive.Flu > Vaccines and An Expanding Vaccine Schedule for the ElderlyPublic > health authorities and physician societies are in an all > outcampaign to have every elderly person vaccinated every year with > theflu vaccine as well as a growing number of newer vaccines. When > I waspracticing neurosurgery, the hospitals had an automatic > written orderon all older patients' charts mandating a flu vaccine, > unless it wascountermanded by the physician, which I always did. > Now, they aregiving the shots in malls, tents and every available > site they canmuster. And worse still, using lies and scare tactics > to frighten theelderly onto getting the shots (such as the bold lie > of 36,000 elderlydying of the flu every year).As you age your > immune system, including that special immune system inyour brain, > releases significantly more inflammatory immune cytokinesthan when > you were younger. This serves to prime the microglia, asdiscussed. > So, when you get your first flu shot your microgliaoverreact and > does so for a very long period -- perhaps years. Manyelderly report > that the flu shot gave them the flu. Proponents ofvaccines, retort > with a condescending laugh, that it is impossiblebecause the flu > vaccine contains killed flu viruses. In truth, whatthese people are > reporting is a prolonged, intense " sickness behavior " response to > the vaccine. To the body, it is worse than getting the > flu.Remember, no one is recording the number of elderly who die > aftergetting the flu shot, especially if they die months later, > which canhappen with sickness behavior, especially if they have a > preexistingchronic illness or are infirm.Here is the shocking > truth. With the elderly already having increasedinflammatory > cytokine levels both systemically and in their brain,stimulating > these primed microglia so that a chronic overstimulation ofthe > brain's immune system is triggered, will not only increase > theirrisk of developing one of the neurodegenerative diseases, but > will alsosubstantially increase their risk of developing major > depression.Remember, this also increases their risk of suicide and > even homicidedramatically.Anxiety is a major problem with > depression, and vaccinations willgreatly worsen the condition. In > fact, vaccination, especially multiplevaccinations, will maintain > the brain in a state of inflammation thatwill be self-perpetuating, > because the excess release of glutamate inthe brain, as well as > glutamate in the diet, will further enhancemicroglial activation > and excitotoxicity.Those who are prone to developing one of the > neurodegenerativediseases, such as Alzheimer's disease or > Parkinson's disease will be ata drastically increased risk as we > have seen experimentally when evenanimals exposed to subtoxic > concentrations of environmental toxins andvaccinated develop > neurologic worsening.Most people use pesticides in their home and > studies have shown thatthe concentrations in homes are sufficient > to trigger Parkinson'sdisease in susceptible people. Vaccinations, > as these studies haveshown, will greatly increase risk. Most > doctors are completely unawareof this important research.You must > keep in mind that " health authorities " urge the elderly to getthe > flu vaccine each and every year. This will keep the microglia in > aprimed and even activated state continuously. Recently, > neurologistsannounced that the incidence of neurodegenerative > disease had beengrossly underestimated and that neurological > diseases of aging wereincreasing at a frightening rate. They have > no explanation. Over thelast three decades the number of elderly > receiving yearly flu vaccineshas risen from 20% before 1980 to over > 60% today.If this were not depressing enough, now the public health > authoritiesand medical specialty societies are adding a whole new > set of vaccinesfor those above 50 years of age, including the > pneumococcal andmeningiococcal vaccines. What is being completely > ignored by thepromoters of these vaccines is the effect of multiple > doses of immuneadjuvant that accompany each of these vaccines.Lets, > say you see your doctor and he talks you into getting the > fluvaccine, the pneumococcal and meningiococcal vaccine all during > thesame office visit. That way, he can save you extra office > visits. Whatyour doctor ignores is that he is giving you three > doses of powerfulimmune adjuvant all in one sitting, which means > that your body andbrain are assaulted by a massive dose of powerful > immune activators,which have been proven to activate the brain's > immune system todangerous levels, even when given as a single dose. > Proof of thismechanism exists not only in animal studies, but in > humans as well.Mercury and AluminumThere are other ways that > vaccines can cause havoc in the brain. Mostvaccines contain > aluminum compounds. A multitude of studies have shownthat aluminum, > especially if combined with fluoride, is a powerfulbrain toxin and > that it accumulates in the brain. With each vaccineinjection, a > dose of aluminum is given. These yearly aluminuminoculations > accumulate not only at the site of the injection, buttravel to the > brain, where it enters neurons and glial cells(astrocytes and > microglia). A number of studies have shown thataluminum can > activate microglia and do so for long periods. This meansthat the > aluminum in your vaccination is priming your microglia tooverreact. > The next vaccine acts to trigger the enhanced inflammatoryreaction > and release of the excitotoxins, glutamate and quinolinicacid.You > must also appreciate that any infection, stroke, head injury > orother toxin exposure will also magnify this inflammatory brain > reactioninitially triggered by your vaccines. Studies have now > indicated thatthe more one's immune system is activated the more > like he or she willsuffer from one of the neurodegenerative > diseases.Mercury is also a powerful activator of brain microglia > and can do soin extremely low concentrations-in nanomolar amounts. > Because of itsnumerous reactions with sulfhydral compounds in the > body (which areubiquitous), mercury can poison a number of enzymes > both systemicallyand in the brain. Of special concern is the > ability of mercury,especially ethylmercury (the kind found in > vaccines called thimerosal)to inhibit the regulation of brain > glutamate levels. (It does this byinhibiting the glutamate transfer > proteins that control the removal ofglutamate from outside the > neuron, where it does its harm.)In essence, mercury, in the > concentrations being injected withvaccines, triggers > excitotoxicity, increases brain free radicals andlipid peroxidation > products, inhibits critical brain enzymes, inhibitsantioxidant > enzymes and impairs DNA repair ability. The flu vaccinecontains > enough mercury to do all of these things. You must keep inmind that > each flu vaccine adds to the mercury supplied by your lastvaccine, > that is, it is progressively accumulating in your brain.In > addition, the aluminum in the vaccines also primes microglia > andwhen combined with mercury is infinitively more toxic to the > brain.Now, if this is not enough, we also have to consider the > contaminationof vaccines with foreign viruses and viral components. > Studies haveshown that this is not a rare occurrence, with up to > 60% of vaccinesbeing contaminated in one study of several major > manufactured vaccines.When confronted with this fact, vaccine > proponents just shrug theirshoulders and say -- " We don't think > these things are harmful. " Yet, the studies say otherwise. It has > been found that insertion ofviral fragments, not even the whole > virus, is sufficient to trigger thebrain's microglial system and > subsequent excitotoxicity, leading toprogressive brain > degeneration. This is accepted to be the mechanism bywhich the HIV > virus causes dementia in a great number of AIDS victims.Fragments > of the virus (gp140 and Tat) are engulfed by the microgliaand this > triggers chronic brain inflammation and excitotoxicity. Theherpes > virus and measles virus can do the same thing.Danger of Live Virus > VaccinesA number of studies have shown that live viruses used in > vaccines canenter the brain and reside there for a lifetime. One > such study, inwhich autopsied elderly were examined for the > presence of the measlesvirus, found that 20% of the brains had live > measles viruses and 45% ofother organs were infected. These viruses > were highly mutated, meaningthat they could be just as potent as > other measles viruses, but couldbe even more virulent. Worse, is > that in most cases they cause asmoldering destruction of tissues > without the obvious symptoms ofinfection, which has been shown in a > number of studies.Live virus vaccines are made using a process to > attenuate thepathogenic or disease-causing virus by passing it > through a series ofcultures. The problem is that the reverse can > also happen within thebody. A number of studies have shown that > when we produce free radicalsin our body (and we produce tons of > such radicals over a lifetime), itmutates the viruses residing in > our tissues. This is what was found inthe autopsy study I referred > to above.Likewise, these viruses can trigger brain inflammation > anddegeneration, which has been shown in a number of studies-that > is,there exist a chronic degeneration of the brain over years or > decades.Because it is so far separated from the time of the > original vaccine,physicians just attribute it to old age or > heredity, anything but thevaccines.Virologists are also concerned > that such mutated live viruses can alsoinfect other people, leading > to outbreaks of disease totallyunsuspected by health > authorities.ConclusionCurrent recommendations by the CDC for adult > vaccinations include atotal of 14 separate inoculations with > infectious agents and powerfulimmune adjuvants. To be fair, some of > these are for special medicalrisks and conditions, such as high- > risk behaviors, illegal drug use andHIV infected individuals. If we > eliminate these, women will be exposedto 10 inoculations and men 7, > should they follow CDC guidelines, whichdoctors follow.According to > CDC recommendations, multiple vaccinations for a singledisease are > separated by no more than 4 weeks, which is close enoughtogether to > produce priming and subsequent hyperactivation of brainmicroglia. > We have seen that this can trigger a smoldering process ofbrain > inflammation and excitotoxicity that can not only result > indepression, anxiety and high suicide rates, but can increase > one's riskof developing one of the neurodegenerative diseases as > well.We have also seen that in many cases a person will be injected > withseveral vaccines during a single office visit and that this > means theirbody is exposed to a very large dose of immune adjuvant. > Compellingstudies, using many animal species as well as humans, > have shown thatthis overactivates brain inflammatory mechanism that > can last foryears.In addition, several additives to vaccines, such > as mercury andaluminum, are powerful brain toxins that are known to > accumulate in thebrain over years and can trigger brain > inflammatory/excitotoxicmechanisms. Vaccine contaminants, such as > bacteria, mycoplasma andviral fragments can also produce prolonged > brain inflammation andneurodegeneration.Because the elderly already > have high levels of inflammatory cytokines,they are at a special > risk. The very young (babies and small children)are at a high risk > because their brains are undergoing the most rapiddevelopment at > the very time they receive the greatest number ofvaccinations -- > the first two years of life. In fact, they receive 22vaccines > during the first year of life, one of which contains a > fullpediatric dose of mercury. Like adults, they receive many > inoculations(up to 9 inoculations) in one office visit. This is > insane and in myestimation, criminal.Nasal flu vaccines are even > worse, because they introduce a live virusinto the nasal passages, > which can then travel along the olfactorynerves, which leads to the > very part of the brain first and mostseverely affected by > Alzheimer's disease. A number of studies haveshown that viruses and > bacteria can pass along this route to the brain.In fact, in one > study scientists sprayed a bacterium into the nose ofmice and > observed a rapid development of Alzheimer's type plaques inthe > mouse's brain.So, what should older people do? First, studies have > shown that theprimary cause of immune deficiency in the elderly is > purely dietary.The carotenoids, such as beta-carotene, alpha- > carotene, canthaxanthin,lutein and lycopene significantly enhance > the immunity of the elderly.Zinc, magnesium and selenium are also > essential. One should also avoidomega-6 oils (the vegetable oils- > corn, safflower, sunflower, canola,soybean and peanut oils), since > they greatly enhance inflammation anddepress immunity. The EPA > component of fish oils (omega-3 oils) is alsoa powerful immune > suppressant. DHA is not. A healthy immune systemmeans that you can > fight infections efficiently and rapidly.Regular exercise, such as > brisk walking or weight exercises three tofive times a week also > boost immunity, while extreme exercisesuppresses immunity. Sugar > and refined carbohydrates also suppressimmunity and inflame the > brain. Exercise protects the brain from agingeffects and from > degeneration.Adequate sleep is also vital to both brain health and > good immunefunction. Pubic health officials and spokesmen for the > major medicalsocieties are lying to the public concerning vaccine > safety. We nowpossess sufficient information from a great number of > studies to haltthis disastrous vaccine policy. We are facing a > medial disaster in thiscountry, which is already well on its way.1. > McGeer PL and McGeer EG. Local neuroinflammation and progression > ofAlzheimer's disease. J Neurovirology 202; 8: 529-538.2. Tavares > RG, et al. Quinolinic acid stimulates synaptosomal glutamaterelease > and inhibits glutamate uptake into astrocytes. Neurochem Int2002; > 40: 621-627.3. Eastman CL, et al. Increased brain quinolinic acid > production inmice infected with a neurotropic measles virus. Exp > Neurol 1994; 125;119-124.4. Glass JD and Wesselingh SL. Microglia > in HIV-associated neurologicaldiseases. Microsc Res Tech 2001; 54: > 95-105.5. Turowski RC and Troozzi PL. Central Nervous System > toxicities ofcytokine therapy: In: Plotnikoff NP, et al, Eds. > Cytokines, Stress andImmunity. Boca Raton, CRC Pres, 1998, pp > 93-114.6. Mrak RE, et al. Glail cytokines and Alzheimer's disease: > Review andpathogenic implications. Human Pathol 1995; 26: > 816-823.7. Klatschmidt C, et al. Stimulation of inotropic glutamate > receptorsactivates transcription factor NFkB in primary neurons. > Proc Nat AcadSci USA 1995; 92: 9618-9622.8. Gao HM, et al Distinct > role for microglia in rotenone-induceddegeneration of dopaminergic > neurons. J Neurosci 2002; 22: 782-790.9. Dyatlov VA et al. neonatal > lead exposure potentates sicknessbehavior by Listeria monocytogenes > infection in mice. Brain Behav Immun2002; 16: 477-492.10. Nakai Y, > et al. Apoptosis and microglial activation in > influenzaencephalopathy. Acta Neuropath (Berl) 2003; 105: > 233-239.11. T et al. NMDA-receptor antagonist prevents > measlesvirus-induced neurodegeneration. Eur J Neurosci 1991; 3: > 66-71.12. Conner TJ, et al. Depression stress immunological > activation: therole of cytokines in depressive disorders. Life > Sciences 1998; 62:583-606.13. Renault PF, et al. Psychiatric > complications of long-termineterferon-alpha therapy. Arch Internal > Medicine 1987; 147: 1577-1580.14. F et al. Neuropsychiatric > manifestations of human leukocyteinterferon therapy in patients > with cancer. JAMA 1984; 252: 938-941.15. Broderick PA, et al. > Interleukin-1a alters hippocampal andnorepinephrine release during > open field behavior in Sprague-Dawleyanimals: differences from the > Fawn-Hooded animal model of depression.Prog Neuropsychopharmacol > Biology 2002; 26: 1355-1372.16. Katayama Y, et al. Detection of > measles virus nucleoprotein mRNA inautopsied brain tissues. J > General Virology 1995; 76: 3201-3204.17. Nicolson GL et al. High > frequency of systemic mycoplasma infectionsin Gulf War Veterans and > civilians with amyotrophic lateral sclerosis.J Clin Sci 2002; 9: > 525-529.18. Blaylock RL. Interaction of cytokines, excitotoxins, > and reactivenitrogen and oxygen species in autism spectrum > disorders. JANA 2003; 6:21-35.19. Blaylock RL. Central role of > excitotoxicity in autism. JANA 2003;6: 7-19.20. Blaylock RL. Food > additive excitotoxins and degenerative braindisorders. Medical > Sentinel 1999; 4: 212-215.21. Blaylock RL. Chronic microglial > activation and excitotoxicitysecondary to excessive immune > stimulation: Possible factors in Gulf WarSyndrome and Autism. J > Amer Phys Surg 2004; 9: 46-51.22. Pilc A, et al. Mood disorders: > regulation by metabotropic glutamatereceptors. Biochem Pharmacol > 2007; (Epub ahead of print)23. Palucha A, Pilc A. The involvement > of glutamate in thepathophysiology of depression. 2005; 18: > 262-268.24. IA, Skolnick P. Glutamate and depression: clinical > andpreclinical studies. Ann NY Acad Sci 2003; 1003: 250-272.25. > Pittenger C, et al. The NMDA receptor as a therapeutic target > inmajor depressive disorder. CNS Neurol Disorders Drug Targets > 2007; 6:101-115.26. Magaki S et al. Increased production of > inflammatory cytokines inmild cognitive impairment. Exp Gerontol > 2007; 42: 233-240.27. Gao H-M et al. Synergistic dopaminergic > neurotoxicity if thepesticide rotenone and inflammogen > lipopolysacchride: relevance to theetiology of Parkinson's disease. > J Neurosciences 2003; 23: 1228-1236.28. Holmes C et al. Systemic > infection, interleukin 1ß, and cognitivedecline. J Neurol > Neurosurgery Psychiatry 2003; 74: 788-789.29. Godbout JP et al. > Exaggerated neuroinflammation and sicknessbehavior in aged mice > after activation of the peripheral innate immunesystem. The FASEB J > 2005; 19: 1329-1331.30. VH et al. The impact of infection on > the progression ofneurodegenerative disease. Nature Rev > Neuroscience 2003;4: 103-112.31. Feiring B et al. Persisting > responses indicating long-termprotection after booster dose with > meningococcal group B outer membranevesicle vaccine. Clin Vaccine > Immunology 2006; 13: 790-796.32. Vaccine Excepients and Media > Summery Center for Disease Control andPrevention. (also the source > for recommended vaccines for adults andchildren).[Non-text portions > of this message have been removed] > > Quote Link to comment Share on other sites More sharing options...
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