temperature and inflammation : autism, PD relevance? - Heat and heart disease is unhealthy combination

[Guest guest]

Perhaps the heat/inflammation connection exacerbates autism, PD, and

other neurologic diseases wherein inflammation is etiologically significant.

In autistic children, among whom a subgroup improves during fever,

externally induced overheating may prompt effects different from

internally induced temperature elevations (?).

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ehn synopsis of open access study:

Heat and heart disease is unhealthy combination. <http://bit.ly/OQKwav>

8 August 2012

An uptick in the body's defense system may explain why congestive heart

failure worsens as temperatures climb. When it's hotter, inflammation --

the body's response to stress or harm -- can increase and lead to more

severe symptoms in those who already have the cardiac problem, report

researchers. This is the first study to look at the link between

temperature and inflammation in those with heart disease and suggests

people with congestive heart failure should avoid the heat.

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Evidence of oxidative damage and inflammation associated with low

glutathione redox status in the autism brain.

<http://www.ncbi.nlm.nih.gov/pubmed/22781167>

Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, SJ.

Transl Psychiatry. 2012 Jul 10;2:e134.

Perinatal stress, brain inflammation and risk of autism-Review and

proposal. <http://www.ncbi.nlm.nih.gov/pubmed/22747567>

Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S,

Theoharides TC.

BMC Pediatr. 2012 Jul 2;12(1):89

Schizophrenia and autism: both shared and disorder-specific pathogenesis

via perinatal inflammation? <http://www.ncbi.nlm.nih.gov/pubmed/21289540>

Meyer U, Feldon J, Dammann O.

Pediatr Res. 2011 May;69(5 Pt 2):26R-33R.

[open access]

Inflammation in Parkinson's disease.

<http://www.ncbi.nlm.nih.gov/pubmed/22814707>

Tufekci KU, Meuwissen R, Genc S, Genc K.

Adv Protein Chem Struct Biol. 2012;88:69-132.