chlorpyrifos - paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression

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Repeated developmental exposure of mice to chlorpyrifos oxon is

associated with paraoxonase 1 (PON1)-modulated effects on cerebellar

gene expression. <http://www.ncbi.nlm.nih.gov/pubmed/21673326>

Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE.

Toxicol Sci. 2011 Jun 14.

Paraoxonase gene variants are associated with autism in North America,

but not in Italy: possible regional specificity in gene-environment

interactions. <http://www.ncbi.nlm.nih.gov/pubmed/16027737>

D'Amelio M, Ricci I, Sacco R, Liu X, D'Agruma L, Muscarella LA,

Guarnieri V, Militerni R, Bravaccio C, Elia M, Schneider C, Melmed R,

Trillo S, Pascucci T, Puglisi-Allegra S, Reichelt KL, Macciardi F,

Holden JJ, Persico AM.

Mol Psychiatry. 2005 Nov;10(11):1006-16.

Chlorpyrifos has been registered to be used both indoors and outdoors as

a pesticide. It is manufactured for both home use as well as commercial

use. ...

http://www.chlorpyrifos.org/

Chlorpyrifos

From Wikipedia

http://en.wikipedia.org/wiki/Chlorpyrifos

Chlorpyrifos (IUPAC name: O,O-diethyl O-3,5,6-trichloropyridin-2-yl

phosphorothioate) is a crystalline organophosphate insecticide that

inhibits acetylcholinesterase and is used to control insect pests. It is

known by many trade names (see table). Chlorpyrifos is moderately toxic

and chronic exposure has been linked to neurological effects,

developmental disorders, and autoimmune disorders. It is considered a

possible endocrine disruptor.[4][5]....