RE: Pandas ( Sue )

[Guest guest]

Hi Sue,

Thank you for the information about the infectious disease doctor !

I read a little about Actos tonight, and I'm wondering why your doctor would

consider using in to control symptoms of Pandas? I really couldn't find anything

in my search ( very limited ) that shows that it would benefit children with

immune dysfunction.

Just curious, did she explain why she believes it might help?

Thanks again and take good care,

[Guest guest]

>Hi ,

Actually, I provided our Infectious Disease doctor with the info.

Actos is a thiazolidinedione type drug which is an agonists of the

peroxisome proliferator activated receptor gamma (PPARy) a nuclear

hormone which modulates insulin sensitivity and have been shown to

induce apoptosis in activated T-lymphocytes and exert

anti-inflammatory effects in glial cells. There is a study in PubMed

central @ www.pubmedcentral.nih.gov/articlerender.fcgi. It is about

the effects of actos treatment on behavioral symptoms in autistic

children. Some of the children had PANDAS. as well as other autoimmune

illnesses. The medication had positive effects on 4 out of 5

subcategories of autistic behaviors. Irritibility, hyperactivity,

lethargy, stereotypy. The article gets in more detail than I can.

I realize Actos does not address immune dysfunction per se, but

does help with neuro inflammation. This should help my son because 6

months ago when had strep, He was on Prednisone which

temporaily helped his autistic symptoms. He played appropriately

which he hadn't done in 2 years. I am just trying to get improved

function for him until there is something out there to treat immune

dysregulation. He is in first grade and can't set still long enough

to print his name, listen to a story, or play with a toy. We are

losing the battle here. ADHD drugs made his OCD go through the roof.

I guess right how I am trying to help him function better by treating

his autoimmune issues.

Sorry for the long post. Take Care.

Hope this makes sense,

Sue

>

> Hi Sue,

>

> Thank you for the information about the infectious disease doctor !

>

> I read a little about Actos tonight, and I'm wondering why your

doctor would consider using in to control symptoms of Pandas? I really

couldn't find anything in my search ( very limited ) that shows that

it would benefit children with immune dysfunction.

>

> Just curious, did she explain why she believes it might help?

>

> Thanks again and take good care,

>

>

>

>

>