Re: Valtrex and Yeast Infections

[Guest guest]

Hi -

Basically, if you need an antiviral or if you have " ASD " , there is an immune

issue, and the antifungals in their least are at least preventative, but usually

is treating.  The antivirals and antifungals together are supporting the immune

system, helping " keep a load off " of two issues that are known to be chronic

problems in , and things that can trigger the immune system.  That's their

" least " purpose - usually something is actually being treated.  By being on

both, you're taking a load off the immune system or potentially removing

triggers that set it off, and hopefully allowing the immune system to cool down

on it's own towhere it may be able to manage itself later.

HTH-

Valtrex and Yeast Infections

Hi all,

Can anybody explain why antifungal medications are recommended when

taking Valtrex? Is it because Valtrex weakens the immune system,

resulting in being more succeptible to the yeast infections?

Thanks,

[Guest guest]

Thank you ,

What if the child never had a yeast infection until the Valtrex was

introduced? I understand the immune issue part, but what I still

don't understand is why many children develop their first yeast

infection after the Valtrex is introduced. Is the antiviral activity

making the children more succeptible to fungal infections? Is it

suppressing the immune system?

Thanks,

>

> Hi -

> Basically, if you need an antiviral or if you have " ASD " , there is

an immune issue, and the antifungals in their least are at least

preventative, but usually is treating.  The antivirals and

antifungals together are supporting the immune system, helping " keep

a load off " of two issues that are known to be chronic problems in

, and things that can trigger the immune system.  That's

their " least " purpose - usually something is actually being treated. 

By being on both, you're taking a load off the immune system or

potentially removing triggers that set it off, and hopefully allowing

the immune system to cool down on it's own towhere it may be able to

manage itself later.

> HTH-

>

>

>

>

> Valtrex and Yeast Infections

>

>

> Hi all,

> Can anybody explain why antifungal medications are recommended when

> taking Valtrex? Is it because Valtrex weakens the immune system,

> resulting in being more succeptible to the yeast infections?

>

> Thanks,

>

>

>

>

>

>

>

>

[Guest guest]

The viral infections, the yeast infection and the high ASO tiers all imply an

immune system that is dysfunctional and is not recognizing these invasive

diseases. All of the meds fight individual infections. What makes it hard to

comprehend is if your child has a viral issue the immune system becomes more

dysfunctional because it has become additionally stressed and fungal or

bacterial agents will take advantage of the weakened condition. Fighting on all

fronts actually allows the immune system to strengthen and eventually address

all issues. That is my take. IF we get the flu all of the health issues go to

hell and back because his immune system becomes less capable to deal with fungus

and bacteria.

Valtrex and Yeast Infections

>

>

> Hi all,

> Can anybody explain why antifungal medications are recommended when

> taking Valtrex? Is it because Valtrex weakens the immune system,

> resulting in being more succeptible to the yeast infections?

>

> Thanks,

>

>

>

>

>

>

>

>

[Guest guest]

Hey ,

You know, I don't really know - can just hypothesize.  He never had a yeast

infection before?  I have heard recently that " antivirals kick up yeast " .  That

wasn't our experience but then we all had yeast before.

However, if the immune system is chronically " upregulated " , and the antiviral

begins to allow the immune system to start " down-regulating " itself, then

perhaps yeast that was usually eradicated immediately is allowed to hang around

more?  If the immune system is really " hot " in response to yeast, then you

wouldn't have a yeast infection, BUT the normal presence of yeast (yeast really

is normal) would also keep it upregulated, so one area cools, another can become

more vulnerable initially. 

I hope some of that makes sense - again I really don't know.

HTH anyway '

Valtrex and Yeast Infections

>

>

> Hi all,

> Can anybody explain why antifungal medications are recommended when

> taking Valtrex? Is it because Valtrex weakens the immune system,

> resulting in being more succeptible to the yeast infections?

>

> Thanks,

>

>

>

>

>

>

>

>

[Guest guest]

One more thought on yeast...

Different antifungals vary in their effectiveness at controlling different

forms of yeast, so there¹s the possibility that when an antifungal

eliminates one form of yeast, it opens up the opportunity for another form

to blossom... that¹s why it¹s important to rotate antifungals.

Caroline

[Guest guest]

Hey i just posted this on another list

It isn't the antiviral itself its the immune systems response. It is

all about cell mediated immunity/ delayed hypersensitivity I tried to

simplfy it but these will give you the idea

Hope it helps

Elyse

Vet Immunol Immunopathol. 2008 Sep 15;125(1-2):47-70. Epub 2008 May

9. Links

Immune response to fungal infections.Blanco JL, ME.

Departamento Sanidad Animal, Facultad de Veterinaria, Universidad

Complutense, 28040 Madrid, Spain. jlblanco@...

The immune mechanisms of defence against fungal infections are

numerous, and range from protective mechanisms that were present

early in evolution (innate immunity) to sophisticated adaptive

mechanisms that are induced specifically during infection and disease

(adaptive immunity). The first-line innate mechanism is the presence

of physical barriers in the form of skin and mucous membranes, which

is complemented by cell membranes, cellular receptors and humoral

factors. There has been a debate about the relative contribution of

humoral and cellular immunity to host defence against fungal

infections. For a long time it was considered that cell-mediated

immunity (CMI) was important, but humoral immunity had little or no

role. However, it is accepted now that CMI is the main mechanism of

defence, but that certain types of antibody response are protective.

In general, Th1-type CMI is required for clearance of a fungal

infection, while Th2 immunity usually results in susceptibility to

infection. Aspergillosis, which is a disease caused by the fungus

Aspergillus, has been the subject of many studies, including details

of the immune response. Attempts to relate aspergillosis to some form

of immunosuppression in animals, as is the case with humans, have not

been successful to date. The defence against Aspergillus is based on

recognition of the pathogen, a rapidly deployed and highly effective

innate effector phase, and a delayed but robust adaptive effector

phase. Candida albicans, part of the normal microbial flora

associated with mucous surfaces, can be present as congenital

candidiasis or as acquired defects of cell-mediated immunity.

Resistance to this yeast is associated with Th1 CMI, whereas Th2

immunity is associated with susceptibility to systemic infection.

Dermatophytes produce skin alterations in humans and other animals,

and the essential role of the CMI response is to destroy the fungi

and produce an immunoprotective status against re-infection. The

resolution of the disease is associated with a delayed hypersensitive

response. There are many effective veterinary vaccines against

dermatophytoses. Malassezia pachydermatis is an opportunistic yeast

that needs predisposing factors to cause disease, often related to an

atopic status in the animal. Two species can be differentiated within

the genus Cryptococcus with immunologic consequences: C. neoformans

infects predominantly immunocompromised hosts, and C. gattii infects

non-immunocompromised hosts. Pneumocystis is a fungus that infects

only immunosupressed individuals, inducing a host defence mechanism

similar to that induced by other fungal pathogens, such as

Aspergillus.

PMID: 18565595 [PubMed - in process]

J Huazhong Univ Sci Technolog Med Sci. 2008 Jun;28(3):352-5. Epub

2008 Jun 19. Links

Local Th1/Th2 cytokine expression in experimental murine vaginal

candidiasis.Ouyang W, Chen S, Liu Z, Wu Y, Li J.

Department of Obstetrics and Gynecology, Union Hospital, Tongji

Medical College, Huazhong University of Science and Technology, Wuhan

430022, China. oY6222@...

In order to investigate the expression of Th1 and Th2 cytokines in

the vaginal candidiasis caused by Candida, the fungal vaginitis model

was established in female ICR mice by intravaginal inoculation of

suspension of C. albicans after the animals were pretreated with

estradiol. Reverse transcriptase-polymerase chain reaction (RT-PCR)

was used to detect the expression of IL-2, IL-4, IL-10 and TGF-beta1

in the vagina in the mice of different groups at different time

points after the beginning of the experiment. The average expression

level of IL-2 mRNA in group D (estrogen-treated mice) was

significantly higher than that in groups H (estrogen-untreated mice)

and I (control group) on the day 2. The average expression level of

IL-4 mRNA in group D was significantly higher than that in groups I

and H on the day 5. The average expression level of IL-10 mRNA in

group D was significantly higher than that in groups H and I from day

7 to 11. The average expression level of TGF-beta1 mRNA in group D

was significantly higher than that in groups H and I at all time

points. It was concludes that the high-level expression of IL-2 mRNA

during early infection was associated with clearance of mucosal C.

albicans, and the high-level expression of IL-10 mRNA during late

stage of the infection was related to susceptibility to infection.

TGF-beta1 may play a predominant role when the virtual absence of

changes in other Th-type cytokines during infection.

PMID: 18563341 [PubMed - in process]

Related ArticlesLocal expression of vaginal Th1 and Th2 cytokines in

murine vaginal candidiasis under different immunity conditions. [J

Huazhong Univ Sci Technolog Med Sci. 2008] Local Th1/Th2 cytokine

production during experimental vaginal candidiasis: potential

importance of transforming growth factor-beta. [Med Mycol. 2000]

Local IL-23 expression in murine vaginal candidiasis and its

relationship with infection and immune status. [J Huazhong Univ Sci

Technolog Med Sci. 2006] Defective antifungal T-helper 1 (TH1)

immunity in a murine model of allogeneic T-cell-depleted bone marrow

transplantation and its restoration by treatment with TH2 cytokine

antagonists. [blood. 2001] Cytokine gene expression in innately

susceptible BALB/c mice and relatively resistant C57BL/6 mice during

infection with virulent Burkholderia pseudomallei.

Curr Opin Microbiol. 1999 Aug;2(4):363-7. Links

Immunity to Candida albicans: Th1, Th2 cells and beyond.Romani L.

Microbiology Section, Department of Experimental Medicine and

Biochemical Sciences, University of Perugia, Italy. Iromani@...

Resistance to Candida albicans infection in mice results from the

development of T helper (Th) type 1 cell responses. Cytokines

produced by Th1 cells activate macrophages and neutrophils to a

candidacidal state. The development of Th2 responses underlines

susceptibility to infection, because cytokines produced by Th2 cells

inhibit Th1 development and deactivate phagocytic effector cells.

With the recognition of the reciprocal influences between innate and

adaptive Th immunity, it appears that the coordinated action of these

two lines of immune defense is required to efficiently oppose the

infectivity of the fungus and to determine its lifelong commensalism

at the mucosal level.

PMID: 10458979 [PubMed - indexed for MEDLINE]

-

-- In , " " <jrodrig6605@...> wrote:

>

> Hi all,

> Can anybody explain why antifungal medications are recommended when

> taking Valtrex? Is it because Valtrex weakens the immune system,

> resulting in being more succeptible to the yeast infections?

>

> Thanks,

>

>