Fw: imunovir/isoprinosine is categorized as a supplement

[Guest guest]

imunovir/isoprinosine is categorized as a supplement

Kaplan's

Chronic Neuroimmune Diseases

Information on CFS, FM, MCS, Lyme Disease, Thyroid, and more...

Last updated April 19, 2007

Balance the Th1/Th2 Immune System

From a talk by Cheney, MD

Transcription by Dallas-Ft Worth CFS Support Group

Written by our group facilitator, this issue's articles are based on tapes

of her October 2000 visit. Dr. Cheney gave permission to share this information,

but has not reviewed or edited it. Articles on other topics will be in the April

2001 newsletter and will soon be available on our website in the section on Dr.

Cheney. These articles likely apply also to FMs patients experience cognitive

difficulties in addition to pain and fatigue, since Dr. Cheney believes they may

also have CFIDS. Dr. Cheney plans to speak in the Dallas - Ft. Worth area on

October 20, 2001. Contact the DFW support group for information, particularly

about the videos that will be available of the seminar.

CFIDS patients are Th2 activated. This means they over-respond to toxins,

allergens, normal bacteria and parasites, and under-respond to viruses, yeast,

cancer and intracellular bacteria. Dr. Cheney suggests six products that can

help rebalance the immune system.

Dr. Cheney explained that the immune system has two different modes of

attack, based on the type of invader. One is Th1 (T Helper 1). It goes after

organisms that get inside our cells , intracellular pathogens. It is also known

as cell-mediated immunity. The other is Th2 (T Helper 2). It attacks

extracellular pathogens , organisms that are found outside the cells in blood

and other body fluids. Some call this humoral or antibody-mediated immunity. A

healthy immune system is dynamic, able to switch back and forth as needed,

quickly eradicating one threat and then resting before responding to the next.

(Dr. Cheney began this conversation by drawing a large inverted " V " . At

the top point he wrote " Th0 " , which he called " Th naught " . The left arrow

pointed down to " Th1 " and the right arrow to " Th2 " . The arrow on the right was

much darker and thicker, indicating that CFIDS patients are Th2 activated.)

Th0 are the naive, or unformed, cells of the immune system. They are

resting, just waiting for an invader. When infection occurs, they convert to

either Th1 or Th2, depending on the type of threat. When the resting cell is

exposed to a virus, cancer, yeast, or intracellular bacteria (like mycoplasma or

chlamydia pneumonia), the Th1 response is initiated. (Dr. Cheney wrote these

organisms beside the left arrow.) The weapons of the Th1 system include

cytotoxic T cells and Natural Killer (NK) cells. (Cheney drew these below

" Th1 " .)

On the other side are normal bacteria, parasites, toxins, and allergens.

(Likewise written beside the right arrow.) These trigger a predominately Th2

response. Its weapons include eosinophiles (Eos), polymononuclear cells (PMN),

and antibody secreting cells (Ab). (Likewise written below " Th2 " .)

How does the naive cell know which pathway to take? It depends on the

cytokine information received. The presence of any organism from the left side

triggers production of a cytokine called Interleukin 12. IL-12 causes the Th0

cell to move down the Th1 path. On the other hand, organisms on the right side

trigger the production of Interleukin 10 (IL-10), which causes the Th0 cell to

move down the Th2 path. (Cheney added small vertical dotted lines on each side,

pointing upward to " IL-12 " on the left and " IL-10 " on the right. He then drew

horizontal dotted arrows from " IL-12 " and " IL-10 " , each pointing inward toward

the " Th0 " , indicating that these cytokines determine whether it will become Th1

or Th2.)

Cheney said this is the point where it gets very interesting. Viruses,

especially herpes viruses like EBV, CMV and HHV6, make proteins that mimic

IL-10. The virus deceives the immune system into thinking that the threat is

coming from the opposite side! So the immune system shifts from the Th1 mode

that attacks viruses to the Th2 mode that does not. The virus increases its

chances of survival by diverting the immune system. It is now thought that many,

if not most, pathogens have this ability. (To represent this effect, Cheney drew

a horizontal arrow about half way down the inverted " V " , originating from the

left side and pointing toward, but not quite touching, the right side. The line

was labeled " IL-10 like peptides " . Below it he drew a similar arrow from the

right side that almost reached the left side. It was labeled " IL-12 like

peptides " .)

Researchers have demonstrated that most CFIDS patients end up stuck in Th2

mode. This has several consequences. When the Th2 system activates, it blocks

the Th1 system. This suppresses the Th1 weapons, particularly NK function.

Accordingly, there is also an increase in the Th2 weapons - the white cells and

antibodies. Most notable is increased antibody production. Dr. Cheney said that

if you measure antibodies to anything a CFIDS patient has ever been exposed to,

they will very likely be elevated. (At this point he drew small arrows beside

the " weapons " : They pointed down on the left side to indicated suppression /

lower levels; and they pointed up on the right side to indicate activation /

higher levels.)

Cheney notes that other problems ensue. Patients get into trouble on both

sides: they overreact to things on the right side and under-react to those on

the left. When they are Th2 activated, they no longer have the defense

mechanisms to keep dormant all the things they caught in the past. They cannot

suppress or control them anymore, and the EBV, chlamydia pneumonia, CMV, etc.

reactivate. The yeast also begins to appear.

The only defense against being eaten alive at this point is RNase L. (For

more information about RNase-L, see The Three Phases of CFIDS and other articles

in the Cheney section of our website.) RNase-L cannot kill any of these things.

It only stops them from reproducing. According to Cheney, " It's a line in the

sand saying 'No more replication', and it waits for Th1 to come and kill them.

But Th1 never comes. RNase L sits there and grinds away, possibly going up and

down as the pathogens activate and reactivate. But they never get wiped out.

RNase L holds the line, waiting for the cavalry that never arrives. "

While it is valiantly trying to hold the line, it is also chewing up human

messenger RNA, inhibiting all the enzymes in the body, disrupting protein

synthesis, and generally making patients miserable. As RNase-L grinds away, it

eventually shifts into " after-burner " desperation mode - the more powerful and

deadly low molecular weight form discovered in CFIDS patients by Suhaldonik.

Cheney commented " RNase-L is a very good anti-cancer defense. So as long

as you're involved in this scenario, you don't get cancer. But a lack of growth

hormone will wipe out RNase-L, and we now know there is profound loss of growth

hormone in CFIDS. Growth hormone is responsible for protein synthesis, and RNase

L is a protein. So if you lose growth hormone, you lose protein synthesis,

including RNase L. That may explain why, as the disease wears on and you get

more injury, you stop seeing high levels of RNase L. You can't make it anymore. "

He believes this is a very scary situation. Patients are Th2 activated and

Th1 suppressed. The things on the left come out and there is nothing to stop

them. There is no Th1, and eventually no Rnase L. He also believes patients need

to balance the immune system - to push it a little more towards Th1. That way

they will lose some of the overreaction on the right and gain some control on

the left.

Cheney recommends the following to help shift the immune system from one

mode to another. They are called " right to left shifters " . Three of them are

published, or near publication.

1) Kutapressin (published, prescription) Kutapressin is an immune

modulator and a broad spectrum anti-viral. Dr. Cheney has found that it is most

effective when the dose is varied or " pulsed " . The dose should vary from 1 to 4

cc daily; see the section on Isoprinosine for this theory. Dr. Cheney strongly

suspects Ampligen is a right-to-left shifter also. He has said in the past that

Kutapressin is rather like a weak form of Ampligen.

2) Isoprinosine (published, prescription) Published for use in CFIDS, this

anti-viral enhances NK function. Dr. Cheney believes it would also be good

against intracellular bacteria since it is a Th2 - Th1 shifter. It appears to

raise IL-12 and lower IL-10, which turns off Th2 and turns on Th1.

It is also called Imunovir and is very nontoxic, very safe. It has been

approved in Europe and Canada for just about any viral infection for 18 years.

It is not approved in the US (for political reasons not safety concerns) but is

easy to get from Ireland with a prescription. Week one, take 6 tablets a day,

Monday through Friday, and none on the weekend. Week two, take 2 tablets a day,

Monday through Friday, and none on the weekend. Repeat this cycle. But do not

treat every month. Do two months on and then one month off of this " pulsing "

dose. This medicine works best when you do not treat regularly. If you treat

continuously at the same dose, it stops working. It is an immune modulator, and

Dr. Cheney suspects all immuno-modulators are like this. If taken continuously

they stop working. The dose must vary so the immune system never knows what to

expect

[Guest guest]

----- Forwarded Message ----

From: Ellen <ejordan1@...>

Sent: Wednesday, January 14, 2009 7:36:18 AM

Subject: imunovir/isoprinosine is categorized as a supplement

Kaplan's

Chronic Neuroimmune Diseases

Information on CFS, FM, MCS, Lyme Disease, Thyroid, and more...

Last updated April 19, 2007

Balance the Th1/Th2 Immune System

From a talk by Cheney, MD

Transcription by Dallas-Ft Worth CFS Support Group

Written by our group facilitator, this issue's articles are based on tapes of

her October 2000 visit. Dr. Cheney gave permission to share this information,

but has not reviewed or edited it. Articles on other topics will be in the April

2001 newsletter and will soon be available on our website in the section on Dr.

Cheney. These articles likely apply also to FMs patients experience cognitive

difficulties in addition to pain and fatigue, since Dr. Cheney believes they may

also have CFIDS. Dr. Cheney plans to speak in the Dallas - Ft. Worth area on

October 20, 2001. Contact the DFW support group for information, particularly

about the videos that will be available of the seminar.

CFIDS patients are Th2 activated. This means they over-respond to toxins,

allergens, normal bacteria and parasites, and under-respond to viruses, yeast,

cancer and intracellular bacteria. Dr. Cheney suggests six products that can

help rebalance the immune system.

Dr. Cheney explained that the immune system has two different modes of attack,

based on the type of invader. One is Th1 (T Helper 1). It goes after organisms

that get inside our cells , intracellular pathogens. It is also known as

cell-mediated immunity. The other is Th2 (T Helper 2). It attacks extracellular

pathogens , organisms that are found outside the cells in blood and other body

fluids. Some call this humoral or antibody-mediated immunity. A healthy immune

system is dynamic, able to switch back and forth as needed, quickly eradicating

one threat and then resting before responding to the next.

(Dr. Cheney began this conversation by drawing a large inverted " V " . At the top

point he wrote " Th0 " , which he called " Th naught " . The left arrow pointed down

to " Th1 " and the right arrow to " Th2 " . The arrow on the right was much darker

and thicker, indicating that CFIDS patients are Th2 activated.)

Th0 are the naive, or unformed, cells of the immune system. They are resting,

just waiting for an invader. When infection occurs, they convert to either Th1

or Th2, depending on the type of threat. When the resting cell is exposed to a

virus, cancer, yeast, or intracellular bacteria (like mycoplasma or chlamydia

pneumonia), the Th1 response is initiated. (Dr. Cheney wrote these organisms

beside the left arrow.) The weapons of the Th1 system include cytotoxic T cells

and Natural Killer (NK) cells. (Cheney drew these below " Th1 " .)

On the other side are normal bacteria, parasites, toxins, and allergens.

(Likewise written beside the right arrow.) These trigger a predominately Th2

response. Its weapons include eosinophiles (Eos), polymononuclear cells (PMN),

and antibody secreting cells (Ab). (Likewise written below " Th2 " .)

How does the naive cell know which pathway to take? It depends on the cytokine

information received. The presence of any organism from the left side triggers

production of a cytokine called Interleukin 12. IL-12 causes the Th0 cell to

move down the Th1 path. On the other hand, organisms on the right side trigger

the production of Interleukin 10 (IL-10), which causes the Th0 cell to move down

the Th2 path. (Cheney added small vertical dotted lines on each side, pointing

upward to " IL-12 " on the left and " IL-10 " on the right. He then drew horizontal

dotted arrows from " IL-12 " and " IL-10 " , each pointing inward toward the " Th0 " ,

indicating that these cytokines determine whether it will become Th1 or Th2.)

Cheney said this is the point where it gets very interesting. Viruses,

especially herpes viruses like EBV, CMV and HHV6, make proteins that mimic

IL-10. The virus deceives the immune system into thinking that the threat is

coming from the opposite side! So the immune system shifts from the Th1 mode

that attacks viruses to the Th2 mode that does not. The virus increases its

chances of survival by diverting the immune system. It is now thought that many,

if not most, pathogens have this ability. (To represent this effect, Cheney drew

a horizontal arrow about half way down the inverted " V " , originating from the

left side and pointing toward, but not quite touching, the right side. The line

was labeled " IL-10 like peptides " . Below it he drew a similar arrow from the

right side that almost reached the left side. It was labeled " IL-12 like

peptides " .)

Researchers have demonstrated that most CFIDS patients end up stuck in Th2 mode.

This has several consequences. When the Th2 system activates, it blocks the Th1

system. This suppresses the Th1 weapons, particularly NK function. Accordingly,

there is also an increase in the Th2 weapons - the white cells and antibodies.

Most notable is increased antibody production. Dr. Cheney said that if you

measure antibodies to anything a CFIDS patient has ever been exposed to, they

will very likely be elevated. (At this point he drew small arrows beside the

" weapons " : They pointed down on the left side to indicated suppression / lower

levels; and they pointed up on the right side to indicate activation / higher

levels.)

Cheney notes that other problems ensue. Patients get into trouble on both sides:

they overreact to things on the right side and under-react to those on the left.

When they are Th2 activated, they no longer have the defense mechanisms to keep

dormant all the things they caught in the past. They cannot suppress or control

them anymore, and the EBV, chlamydia pneumonia, CMV, etc. reactivate. The yeast

also begins to appear.

The only defense against being eaten alive at this point is RNase L. (For more

information about RNase-L, see The Three Phases of CFIDS and other articles in

the Cheney section of our website.) RNase-L cannot kill any of these things. It

only stops them from reproducing. According to Cheney, " It's a line in the sand

saying 'No more replication' , and it waits for Th1 to come and kill them. But

Th1 never comes. RNase L sits there and grinds away, possibly going up and down

as the pathogens activate and reactivate. But they never get wiped out. RNase L

holds the line, waiting for the cavalry that never arrives. "

While it is valiantly trying to hold the line, it is also chewing up human

messenger RNA, inhibiting all the enzymes in the body, disrupting protein

synthesis, and generally making patients miserable. As RNase-L grinds away, it

eventually shifts into " after-burner " desperation mode - the more powerful and

deadly low molecular weight form discovered in CFIDS patients by Suhaldonik.

Cheney commented " RNase-L is a very good anti-cancer defense. So as long as

you're involved in this scenario, you don't get cancer. But a lack of growth

hormone will wipe out RNase-L, and we now know there is profound loss of growth

hormone in CFIDS. Growth hormone is responsible for protein synthesis, and RNase

L is a protein. So if you lose growth hormone, you lose protein synthesis,

including RNase L. That may explain why, as the disease wears on and you get

more injury, you stop seeing high levels of RNase L. You can't make it anymore. "

He believes this is a very scary situation. Patients are Th2 activated and Th1

suppressed. The things on the left come out and there is nothing to stop them.

There is no Th1, and eventually no Rnase L. He also believes patients need to

balance the immune system - to push it a little more towards Th1. That way they

will lose some of the overreaction on the right and gain some control on the

left.

Cheney recommends the following to help shift the immune system from one mode to

another. They are called " right to left shifters " . Three of them are published,

or near publication.

1) Kutapressin (published, prescription) Kutapressin is an immune modulator and

a broad spectrum anti-viral. Dr. Cheney has found that it is most effective when

the dose is varied or " pulsed " . The dose should vary from 1 to 4 cc daily; see

the section on Isoprinosine for this theory. Dr. Cheney strongly suspects

Ampligen is a right-to-left shifter also. He has said in the past that

Kutapressin is rather like a weak form of Ampligen.

2) Isoprinosine (published, prescription) Published for use in CFIDS, this

anti-viral enhances NK function. Dr. Cheney believes it would also be good

against intracellular bacteria since it is a Th2 - Th1 shifter. It appears to

raise IL-12 and lower IL-10, which turns off Th2 and turns on Th1.

It is also called Imunovir and is very nontoxic, very safe. It has been approved

in Europe and Canada for just about any viral infection for 18 years. It is not

approved in the US (for political reasons not safety concerns) but is easy to

get from Ireland with a prescription. Week one, take 6 tablets a day, Monday

through Friday, and none on the weekend. Week two, take 2 tablets a day, Monday

through Friday, and none on the weekend. Repeat this cycle. But do not treat

every month. Do two months on and then one month off of this " pulsing " dose.

This medicine works best when you do not treat regularly. If you treat

continuously at the same dose, it stops working. It is an immune modulator, and

Dr. Cheney suspects all immuno-modulators are like this. If taken continuously

they stop working. The dose must vary so the immune system never knows what to

expect