Stem Cell Research May Provide Add'l Answers.

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_Science And Study_ (http://living.oneindia.in/health/science-study/2007/) A

breakthrough _study_

(http://living.oneindia.in/health/disorders-and-ailments/2008/stem-cell-mutation\

-autism-010708.html#) on mice has shown that

mutations in neural stem cell development may be linked to autism.

Reported in the Proceedings of the National Academy of Sciences by experts

at the Burnham Institute for Medical Research, the study showed that mice

lacking the myocyte enhancer factor 2C (MEF2C) protein in neural stem cells had

smaller brains, fewer nerve cells and showed behaviours similar to those seen

in humans with a form of autism known as Rett Syndrome.

Dr. Stuart A. Lipton, a clinical neurologist who led the study, claims that

his team " s study represents the first direct link between a developmental

disorder of neural stem cells and the subsequent onset of autism.

" These results give us a good hint of how to look at Rett Syndrome and

potentially other forms of autism in humans. Having identified a mutation that

causes this defect, we can track what happens. Perhaps we can correct it in a

mouse, and if so, eventually correct it in humans, " said Dr. Lipton.

Working in Dr. Lipton's laboratory, the research team observed that MEF2C

turns on specific genes, which drive stem cells to become nerve cells.

The researchers also observed a faulty distribution of neurons, accompanied

by severe developmental problems, when they deleted MEF2C from neural stem

cells in the animals.

They have revealed that adult mice lacking MEF2C in their brains displayed

abnormal anxiety-like behaviours, decreased cognitive function, and marked paw

clasping, a behaviour which may be analogous to hand wringing, a notable

feature in humans with Rett syndrome.

" There's a yin and yang to this MEF2C protein. My laboratory recently showed

that MEF2C induces _embryonic stem cells_

(http://living.oneindia.in/health/disorders-and-ailments/2008/stem-cell-mutation\

-autism-010708.html#) to become

neurons. In this new research, we show that knocking out MEFC2 in the brain

results in mice with smaller brains, fewer neurons and reduced neuronal

activity. The commonality is the protein's association in making new neurons, "

said Dr. Lipton.

Tags: _mutation_ (http://living.oneindia.in/tag/mutation) , _autism_

(http://living.oneindia.in/tag/autism) , _rett syndrome_

(http://living.oneindia.in/tag/rett+syndrome) , _anxiety_

(http://living.oneindia.in/tag/anxiety) ,

_protein_ (http://living.oneindia.in/tag/protein) , _neurons_

(http://living.oneindia.in/tag/neurons) , _genes_

(http://living.oneindia.in/tag/genes) , _clinical

neurologist_ (http://living.oneindia.in/tag/clinical+neurologist) ,

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" Ms. Michele "

**************Feeling the pinch at the grocery store? Make dinner for $10 or

less. (http://food.aol.com/frugal-feasts?ncid=emlcntusfood00000001)