Re: A Genetic Clue to Why Autism Affects Boys More

[Guest guest]

>

>

> oh there. I was wondering why my site was getting so many hits today, people

> googling autism and calcium like mad.

>

> this research is more or less flaggin the dead horse (unless they take it in a

> useful direction now, which I highly doubt). They better look into how

> pathogens screw up calcium signalling, and also how male hormones in asd boys

> influence those pathways. And how female hormones stop calcium excesses. Which

> is why the different rates in boys and girls imo

>

> sorry for the rant, just hate to see research money being wasted.

>

> Natasa

> http://autismcalciumchannelopathy.com/Infectious_Agents.html#

>

>

>

> Here is something published in Time . what do we make of this?

>

> A Genetic Clue to Why Autism Affects Boys More

>

> TIME

>

> By ALICE PARK Alice Park - Wed May 20, 6:20 am ET

>

> Among the many mysteries that befuddle autism researchers: why the disorder

> affects boys four times more often than girls. But in new findings reported

> online today by the journal Molecular Psychiatry, researchers say they have

> found a genetic clue that may help explain the disparity.

>

> The newly discovered autism

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=11p54fant/* " >http:/www.time.com/time/topics/autism/0,30939,,00.html>

> <http:/www.time.com/time/topics/autism/0,30939,,00.html>

> -risk gene, identified by authors as CACNA1G, is more common in boys than in

> girls (why that's so is still not clear), and the authors suggest it plays a

> role in boys' increased risk of the developmental disorder. CACNA1G, which

> sits on chromosome 17, amid other genes that have been previously linked to

> autism, is responsible for regulating the flow of calcium into and out of

> cells. Nerve cells in the brain rely on calcium to become activated, and

> research suggests that imbalances in the mineral can result in the

> overstimulation of neural connections and create developmental problems,

> such as autism and even epilepsy, which is also a common feature of autism.

> (

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=12kvbetpo/*http:/www.time.com/time/specials/packages/article/0,2880

> 4,1893554_1893556,00.html> See six tips for traveling with an autistic

> child.)

>

> " Our current theories about autism suggest that the disorder is related to

> overexcitability at nerve endings, " says Geri Dawson, chief science officer

> of Autism Speaks, an advocacy group that provided the genetic data used by

> the study's authors. " It's interesting to see that the gene they identified

> appears to modulate excitability of neurons. "

>

> For the new study, researchers at the University of California, Los Angeles

> (UCLA), combed the genetic database of the Autism Genetic Resource Exchange

> (AGRE), a resource of DNA from 2,000 families with at least one autistic

> child. The scientists focused on the more than 1,000 genetic samples of

> families in which at least one son was affected by the disorder, prompted by

> the results of an earlier study using the same database, which identified a

> rich autism-related genetic region on chromosome 17 that contained genetic

> variants more common in boys than in girls. While nearly 40% of the general

> population has the most common form of CACNA1G, one variant of the gene was

> more prevalent in autistic boys, researchers found. " There is a strong

> genetic signal in this region, " says Dr. Geschwind, director of

> UCLA's Center for Autism Research and Treatment and one of the study's

> co-authors. " But this gene doesn't explain all of that signal or even half

> of it. What that means is that there are many more genes in this region

> contributing to autism. " (

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=11pkhspim/* " >http:/www.time.com/time/photoessays/2006/autismschool/>

> <http:/www.time.com/time/photoessays/2006/autismschool/>

> See pictures of inside a school for autistic children.)

>

> That's not surprising for a disorder as complex as autism - actually, a

> spectrum of developmental disorders involving impairment in language, social

> behavior and certain physical behaviors - with symptoms that range widely in

> number and severity. So far, studies have linked a handful of genes, all of

> which play a role in the way

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=1225o0np0/*http:/www.time.com/time/magazine/article/0,9171,1191843,

> 00.html> nerve cells connect and communicate, with autism spectrum

> disorders. It's likely not only that a large number of genes contribute to

> the disorder, but also that a different combination of genes - as well as

> unique interactions between genes and environment - are responsible for each

> individual case of autism.

>

> So it's certainly a daunting challenge to begin teasing out the individual

> genes that may contribute to autism, as the UCLA team has with CACNA1G, but

> databases like AGRE make the job slightly easier. The next step will be to

> try to use known autism genes to help develop screening tools or early

> interventions. " We are going to have a much better understanding of the

> causes of autism over the next five to 10 years, " says Dawson. " We're in a

> period of great discovery. "

>

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=11cm8egb0/* " >http:/www.time.com/time/picturesoftheweek>

> <http:/www.time.com/time/picturesoftheweek> See TIME's

> Pictures of the Week.

>

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=12k70eqgn/*http:/www.time.com/time/specials/packages/article/0,2880

> 4,1847616_1847615,00.html> See the most common hospital mishaps.

>

> View this article on

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=12s931o9q/*http:/www.time.com/time/health/article/0,8599,1899756,00

> .html?xid=rss-fullhealthsci-> Time.com

>

> Related articles on Time.com:

>

> *

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=13387bjf5/*http:/www.time.com/time/health/article/0,8599,1894409,00

> .html?xid=feed--full-health-related> Autism Linked to Genes That Govern

> How the Brain Is Wired

> *

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=133stcntl/*http:/www.time.com/time/health/article/0,8599,1821595,00

> .html?xid=feed--full-health-related> New Clues to Autism's Cause

> *

> <http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=1339lkvp2/*http:/www.time.com/time/health/article/0,8599,1895357,00

> .html?xid=feed--full-health-related> Researchers Find First Signs of

> Autism Even in Infancy

>

>

[Guest guest]

Tks Natasa -that makes sense!

_____

From: [mailto: ] On Behalf Of

Neno/Natasa

Sent: Wednesday, May 20, 2009 11:09 AM

Subject: Re: A Genetic Clue to Why Autism Affects Boys More

>

>

> oh there. I was wondering why my site was getting so many hits today,

people

> googling autism and calcium like mad.

>

> this research is more or less flaggin the dead horse (unless they take it

in a

> useful direction now, which I highly doubt). They better look into how

> pathogens screw up calcium signalling, and also how male hormones in asd

boys

> influence those pathways. And how female hormones stop calcium excesses.

Which

> is why the different rates in boys and girls imo

>

> sorry for the rant, just hate to see research money being wasted.

>

> Natasa

> http://autismcalciu

<http://autismcalciumchannelopathy.com/Infectious_Agents.html>

mchannelopathy.com/Infectious_Agents.html#

>

>

>

> Here is something published in Time . what do we make of this?

>

> A Genetic Clue to Why Autism Affects Boys More

>

> TIME

>

> By ALICE PARK Alice Park - Wed May 20, 6:20 am ET

>

> Among the many mysteries that befuddle autism researchers: why the

disorder

> affects boys four times more often than girls. But in new findings

reported

> online today by the journal Molecular Psychiatry, researchers say they

have

> found a genetic clue that may help explain the disparity.

>

> The newly discovered autism

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=11p54fant/* " >http:/www.time.com/time/topics/autism/0,30939,,00.html

>

> <http:/www.time.com/time/topics/autism/0,30939,,00.html>

> -risk gene, identified by authors as CACNA1G, is more common in boys than

in

> girls (why that's so is still not clear), and the authors suggest it plays

a

> role in boys' increased risk of the developmental disorder. CACNA1G, which

> sits on chromosome 17, amid other genes that have been previously linked

to

> autism, is responsible for regulating the flow of calcium into and out of

> cells. Nerve cells in the brain rely on calcium to become activated, and

> research suggests that imbalances in the mineral can result in the

> overstimulation of neural connections and create developmental problems,

> such as autism and even epilepsy, which is also a common feature of

autism.

> (

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=12kvbetpo/*http:/www.time.com/time/specials/packages/article/0,2880

> 4,1893554_1893556,00.html> See six tips for traveling with an autistic

> child.)

>

> " Our current theories about autism suggest that the disorder is related to

> overexcitability at nerve endings, " says Geri Dawson, chief science

officer

> of Autism Speaks, an advocacy group that provided the genetic data used by

> the study's authors. " It's interesting to see that the gene they

identified

> appears to modulate excitability of neurons. "

>

> For the new study, researchers at the University of California, Los

Angeles

> (UCLA), combed the genetic database of the Autism Genetic Resource

Exchange

> (AGRE), a resource of DNA from 2,000 families with at least one autistic

> child. The scientists focused on the more than 1,000 genetic samples of

> families in which at least one son was affected by the disorder, prompted

by

> the results of an earlier study using the same database, which identified

a

> rich autism-related genetic region on chromosome 17 that contained genetic

> variants more common in boys than in girls. While nearly 40% of the

general

> population has the most common form of CACNA1G, one variant of the gene

was

> more prevalent in autistic boys, researchers found. " There is a strong

> genetic signal in this region, " says Dr. Geschwind, director of

> UCLA's Center for Autism Research and Treatment and one of the study's

> co-authors. " But this gene doesn't explain all of that signal or even half

> of it. What that means is that there are many more genes in this region

> contributing to autism. " (

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=11pkhspim/* " >http:/www.time.com/time/photoessays/2006/autismschool/

>

> <http:/www.time.com/time/photoessays/2006/autismschool/>

> See pictures of inside a school for autistic children.)

>

> That's not surprising for a disorder as complex as autism - actually, a

> spectrum of developmental disorders involving impairment in language,

social

> behavior and certain physical behaviors - with symptoms that range widely

in

> number and severity. So far, studies have linked a handful of genes, all

of

> which play a role in the way

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=1225o0np0/*http:/www.time.com/time/magazine/article/0,9171,1191843,

> 00.html> nerve cells connect and communicate, with autism spectrum

> disorders. It's likely not only that a large number of genes contribute to

> the disorder, but also that a different combination of genes - as well as

> unique interactions between genes and environment - are responsible for

each

> individual case of autism.

>

> So it's certainly a daunting challenge to begin teasing out the individual

> genes that may contribute to autism, as the UCLA team has with CACNA1G,

but

> databases like AGRE make the job slightly easier. The next step will be to

> try to use known autism genes to help develop screening tools or early

> interventions. " We are going to have a much better understanding of the

> causes of autism over the next five to 10 years, " says Dawson. " We're in a

> period of great discovery. "

>

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

> 3688/SIG=11cm8egb0/* " >http:/www.time.com/time/picturesoftheweek>

> <http:/www.time.com/time/picturesoftheweek> See TIME's

> Pictures of the Week.

>

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=12k70eqgn/*http:/www.time.com/time/specials/packages/article/0,2880

> 4,1847616_1847615,00.html> See the most common hospital mishaps.

>

> View this article on

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=12s931o9q/*http:/www.time.com/time/health/article/0,8599,1899756,00

> .html?xid=rss-fullhealthsci-> Time.com

>

> Related articles on Time.com:

>

> *

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=13387bjf5/*http:/www.time.com/time/health/article/0,8599,1894409,00

> .html?xid=feed--full-health-related> Autism Linked to Genes That

Govern

> How the Brain Is Wired

> *

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=133stcntl/*http:/www.time.com/time/health/article/0,8599,1821595,00

> .html?xid=feed--full-health-related> New Clues to Autism's Cause

> *

> <http://us.rd.

<http://us.rd./dailynews/time/hl_time/storytext/08599189975600/3207

> /dailynews/time/hl_time/storytext/08599189975600/3207

>

3688/SIG=1339lkvp2/*http:/www.time.com/time/health/article/0,8599,1895357,00

> .html?xid=feed--full-health-related> Researchers Find First Signs of

> Autism Even in Infancy

>

>

[Guest guest]

What role does calcium supplementation play?  Can more calcium in the child's

diet help?

From: Neno/Natasa <neno@...>

Subject: Re: A Genetic Clue to Why Autism Affects Boys More

Date: Wednesday, May 20, 2009, 6:09 PM

>

>

> oh there. I was wondering why my site was getting so many hits today, people

> googling autism and calcium like mad.

>

> this research is more or less flaggin the dead horse (unless they take it in a

> useful direction now, which I highly doubt). They better look into how

> pathogens screw up calcium signalling, and also how male hormones in asd boys

> influence those pathways. And how female hormones stop calcium excesses. Which

> is why the different rates in boys and girls imo

>

> sorry for the rant, just hate to see research money being wasted.

>

> Natasa

> http://autismcalciu mchannelopathy. com/Infectious_ Agents.html#

>

>

>

> Here is something published in Time . what do we make of this?

>

> A Genetic Clue to Why Autism Affects Boys More

>

> TIME

>

> By ALICE PARK Alice Park - Wed May 20, 6:20 am ET

>

> Among the many mysteries that befuddle autism researchers: why the disorder

> affects boys four times more often than girls. But in new findings reported

> online today by the journal Molecular Psychiatry, researchers say they have

> found a genetic clue that may help explain the disparity.

>

> The newly discovered autism

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=11p54fant/ * " >http:/ www.time. com/time/ topics/autism/ 0,30939,,

00.html>

> <http:/www.time. com/time/ topics/autism/ 0,30939,, 00.html>

> -risk gene, identified by authors as CACNA1G, is more common in boys than in

> girls (why that's so is still not clear), and the authors suggest it plays a

> role in boys' increased risk of the developmental disorder. CACNA1G, which

> sits on chromosome 17, amid other genes that have been previously linked to

> autism, is responsible for regulating the flow of calcium into and out of

> cells. Nerve cells in the brain rely on calcium to become activated, and

> research suggests that imbalances in the mineral can result in the

> overstimulation of neural connections and create developmental problems,

> such as autism and even epilepsy, which is also a common feature of autism.

> (

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=12kvbetpo/ *http:/www. time.com/ time/specials/ packages/ article/0,

2880

> 4,1893554_1893556, 00.html> See six tips for traveling with an autistic

> child.)

>

> " Our current theories about autism suggest that the disorder is related to

> overexcitability at nerve endings, " says Geri Dawson, chief science officer

> of Autism Speaks, an advocacy group that provided the genetic data used by

> the study's authors. " It's interesting to see that the gene they identified

> appears to modulate excitability of neurons. "

>

> For the new study, researchers at the University of California, Los Angeles

> (UCLA), combed the genetic database of the Autism Genetic Resource Exchange

> (AGRE), a resource of DNA from 2,000 families with at least one autistic

> child. The scientists focused on the more than 1,000 genetic samples of

> families in which at least one son was affected by the disorder, prompted by

> the results of an earlier study using the same database, which identified a

> rich autism-related genetic region on chromosome 17 that contained genetic

> variants more common in boys than in girls. While nearly 40% of the general

> population has the most common form of CACNA1G, one variant of the gene was

> more prevalent in autistic boys, researchers found. " There is a strong

> genetic signal in this region, " says Dr. Geschwind, director of

> UCLA's Center for Autism Research and Treatment and one of the study's

> co-authors. " But this gene doesn't explain all of that signal or even half

> of it. What that means is that there are many more genes in this region

> contributing to autism. " (

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=11pkhspim/ * " >http:/ www.time. com/time/ photoessays/

2006/autismschoo l/>

> <http:/www.time. com/time/ photoessays/ 2006/autismschoo l/>

> See pictures of inside a school for autistic children.)

>

> That's not surprising for a disorder as complex as autism - actually, a

> spectrum of developmental disorders involving impairment in language, social

> behavior and certain physical behaviors - with symptoms that range widely in

> number and severity. So far, studies have linked a handful of genes, all of

> which play a role in the way

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=1225o0np0/ *http:/www. time.com/ time/magazine/ article/0,

9171,1191843,

> 00.html> nerve cells connect and communicate, with autism spectrum

> disorders. It's likely not only that a large number of genes contribute to

> the disorder, but also that a different combination of genes - as well as

> unique interactions between genes and environment - are responsible for each

> individual case of autism.

>

> So it's certainly a daunting challenge to begin teasing out the individual

> genes that may contribute to autism, as the UCLA team has with CACNA1G, but

> databases like AGRE make the job slightly easier. The next step will be to

> try to use known autism genes to help develop screening tools or early

> interventions. " We are going to have a much better understanding of the

> causes of autism over the next five to 10 years, " says Dawson. " We're in a

> period of great discovery. "

>

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=11cm8egb0/ * " >http:/ www.time. com/time/ picturesofthewee k>

> <http:/www.time. com/time/ picturesofthewee k> See TIME's

> Pictures of the Week.

>

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=12k70eqgn/ *http:/www. time.com/ time/specials/ packages/ article/0,

2880

> 4,1847616_1847615, 00.html> See the most common hospital mishaps.

>

> View this article on

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=12s931o9q/ *http:/www. time.com/ time/health/ article/0,

8599,1899756, 00

> .html?xid=rss- fullhealthsci- > Time.com

>

> Related articles on Time.com:

>

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=13387bjf5/ *http:/www. time.com/ time/health/ article/0,

8599,1894409, 00

> .html?xid=feed- -full- health-related> Autism Linked to Genes That Govern

> How the Brain Is Wired

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=133stcntl/ *http:/www. time.com/ time/health/ article/0,

8599,1821595, 00

> .html?xid=feed- -full- health-related> New Clues to Autism's Cause

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=1339lkvp2/ *http:/www. time.com/ time/health/ article/0,

8599,1895357, 00

> .html?xid=feed- -full- health-related> Researchers Find First Signs of

> Autism Even in Infancy

>

>

[Guest guest]

Dr. G once told me my son has enough natural calcium, but that it appears to

be too much because his body is not processing/absorbing it. Could this be

the problem?

Kristy

From: [mailto: ] On Behalf Of

Houston

Sent: Wednesday, May 20, 2009 11:29 AM

Subject: Re: A Genetic Clue to Why Autism Affects Boys More

What role does calcium supplementation play? Can more calcium in the

child's diet help?

From: Neno/Natasa <neno@...

<mailto:neno%40dalmaholidays.co.uk> >

Subject: Re: A Genetic Clue to Why Autism Affects Boys More

<mailto:%40>

Date: Wednesday, May 20, 2009, 6:09 PM

>

>

> oh there. I was wondering why my site was getting so many hits today,

people

> googling autism and calcium like mad.

>

> this research is more or less flaggin the dead horse (unless they take it

in a

> useful direction now, which I highly doubt). They better look into how

> pathogens screw up calcium signalling, and also how male hormones in asd

boys

> influence those pathways. And how female hormones stop calcium excesses.

Which

> is why the different rates in boys and girls imo

>

> sorry for the rant, just hate to see research money being wasted.

>

> Natasa

> http://autismcalciu mchannelopathy. com/Infectious_ Agents.html#

>

>

>

> Here is something published in Time . what do we make of this?

>

> A Genetic Clue to Why Autism Affects Boys More

>

> TIME

>

> By ALICE PARK Alice Park - Wed May 20, 6:20 am ET

>

> Among the many mysteries that befuddle autism researchers: why the

disorder

> affects boys four times more often than girls. But in new findings

reported

> online today by the journal Molecular Psychiatry, researchers say they

have

> found a genetic clue that may help explain the disparity.

>

> The newly discovered autism

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=11p54fant/ * " >http:/ www.time. com/time/ topics/autism/ 0,30939,,

00.html>

> <http:/www.time. com/time/ topics/autism/ 0,30939,, 00.html>

> -risk gene, identified by authors as CACNA1G, is more common in boys than

in

> girls (why that's so is still not clear), and the authors suggest it plays

a

> role in boys' increased risk of the developmental disorder. CACNA1G, which

> sits on chromosome 17, amid other genes that have been previously linked

to

> autism, is responsible for regulating the flow of calcium into and out of

> cells. Nerve cells in the brain rely on calcium to become activated, and

> research suggests that imbalances in the mineral can result in the

> overstimulation of neural connections and create developmental problems,

> such as autism and even epilepsy, which is also a common feature of

autism.

> (

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=12kvbetpo/ *http:/www. time.com/ time/specials/ packages/

article/0, 2880

> 4,1893554_1893556, 00.html> See six tips for traveling with an autistic

> child.)

>

> " Our current theories about autism suggest that the disorder is related to

> overexcitability at nerve endings, " says Geri Dawson, chief science

officer

> of Autism Speaks, an advocacy group that provided the genetic data used by

> the study's authors. " It's interesting to see that the gene they

identified

> appears to modulate excitability of neurons. "

>

> For the new study, researchers at the University of California, Los

Angeles

> (UCLA), combed the genetic database of the Autism Genetic Resource

Exchange

> (AGRE), a resource of DNA from 2,000 families with at least one autistic

> child. The scientists focused on the more than 1,000 genetic samples of

> families in which at least one son was affected by the disorder, prompted

by

> the results of an earlier study using the same database, which identified

a

> rich autism-related genetic region on chromosome 17 that contained genetic

> variants more common in boys than in girls. While nearly 40% of the

general

> population has the most common form of CACNA1G, one variant of the gene

was

> more prevalent in autistic boys, researchers found. " There is a strong

> genetic signal in this region, " says Dr. Geschwind, director of

> UCLA's Center for Autism Research and Treatment and one of the study's

> co-authors. " But this gene doesn't explain all of that signal or even half

> of it. What that means is that there are many more genes in this region

> contributing to autism. " (

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=11pkhspim/ * " >http:/ www.time. com/time/ photoessays/

2006/autismschoo l/>

> <http:/www.time. com/time/ photoessays/ 2006/autismschoo l/>

> See pictures of inside a school for autistic children.)

>

> That's not surprising for a disorder as complex as autism - actually, a

> spectrum of developmental disorders involving impairment in language,

social

> behavior and certain physical behaviors - with symptoms that range widely

in

> number and severity. So far, studies have linked a handful of genes, all

of

> which play a role in the way

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=1225o0np0/ *http:/www. time.com/ time/magazine/ article/0,

9171,1191843,

> 00.html> nerve cells connect and communicate, with autism spectrum

> disorders. It's likely not only that a large number of genes contribute to

> the disorder, but also that a different combination of genes - as well as

> unique interactions between genes and environment - are responsible for

each

> individual case of autism.

>

> So it's certainly a daunting challenge to begin teasing out the individual

> genes that may contribute to autism, as the UCLA team has with CACNA1G,

but

> databases like AGRE make the job slightly easier. The next step will be to

> try to use known autism genes to help develop screening tools or early

> interventions. " We are going to have a much better understanding of the

> causes of autism over the next five to 10 years, " says Dawson. " We're in a

> period of great discovery. "

>

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=11cm8egb0/ * " >http:/ www.time. com/time/ picturesofthewee k>

> <http:/www.time. com/time/ picturesofthewee k> See TIME's

> Pictures of the Week.

>

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=12k70eqgn/ *http:/www. time.com/ time/specials/ packages/

article/0, 2880

> 4,1847616_1847615, 00.html> See the most common hospital mishaps.

>

> View this article on

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=12s931o9q/ *http:/www. time.com/ time/health/ article/0,

8599,1899756, 00

> .html?xid=rss- fullhealthsci- > Time.com

>

> Related articles on Time.com:

>

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=13387bjf5/ *http:/www. time.com/ time/health/ article/0,

8599,1894409, 00

> .html?xid=feed- -full- health-related> Autism Linked to Genes That

Govern

> How the Brain Is Wired

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=133stcntl/ *http:/www. time.com/ time/health/ article/0,

8599,1821595, 00

> .html?xid=feed- -full- health-related> New Clues to Autism's Cause

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/

08599189975600/ 3207

> 3688/SIG=1339lkvp2/ *http:/www. time.com/ time/health/ article/0,

8599,1895357, 00

> .html?xid=feed- -full- health-related> Researchers Find First Signs

of

> Autism Even in Infancy

>

>

[Guest guest]

>

> from my experience and talking to many others calcium from a supplement is a

> big problem. Our son had a severe regression when we tried supplementing.

> Kirsy is right here it is not so much the amount of calcium in the body but

> that it is used in a Œwrong¹ way, not processing as it should.

> having said that there are kids that do well on it, actually in few rare cases

> that I know of the kids really do need it in supplemental form. Some of those

> that do well on it take it in calcium/magnesium combo.

>

> Natasa

>

>

>

> Dr. G once told me my son has enough natural calcium, but that it appears to

> be too much because his body is not processing/absorbing it. Could this be

> the problem?

>

> Kristy

>

> From: <mailto:%40>

> [mailto: <mailto:%40> ] On Behalf Of

>

> Houston

> Sent: Wednesday, May 20, 2009 11:29 AM

> <mailto:%40>

> Subject: Re: A Genetic Clue to Why Autism Affects Boys More

>

>

> What role does calcium supplementation play? Can more calcium in the

> child's diet help?

>

>

>

> From: Neno/Natasa <neno@...

> <mailto:neno%40dalmaholidays.co.uk>

> <mailto:neno%40dalmaholidays.co.uk> >

> Subject: Re: A Genetic Clue to Why Autism Affects Boys More

> <mailto:%40>

> <mailto:%40>

> Date: Wednesday, May 20, 2009, 6:09 PM

>

>> >

>

>> >

>

>> > oh there. I was wondering why my site was getting so many hits today,

> people

>

>> > googling autism and calcium like mad.

>

>> >

>

>> > this research is more or less flaggin the dead horse (unless they take it

> in a

>

>> > useful direction now, which I highly doubt). They better look into how

>

>> > pathogens screw up calcium signalling, and also how male hormones in asd

> boys

>

>> > influence those pathways. And how female hormones stop calcium excesses.

> Which

>

>> > is why the different rates in boys and girls imo

>

>> >

>

>> > sorry for the rant, just hate to see research money being wasted.

>

>> >

>

>> > Natasa

>

>> > http://autismcalciu mchannelopathy. com/Infectious_ Agents.html#

>

>> >

>

>> >

>

>> >

>

>> > Here is something published in Time . what do we make of this?

>

>> >

>

>> > A Genetic Clue to Why Autism Affects Boys More

>

>> >

>

>> > TIME

>

>> >

>

>> > By ALICE PARK Alice Park - Wed May 20, 6:20 am ET

>

>> >

>

>> > Among the many mysteries that befuddle autism researchers: why the

> disorder

>

>> > affects boys four times more often than girls. But in new findings

> reported

>

>> > online today by the journal Molecular Psychiatry, researchers say they

> have

>

>> > found a genetic clue that may help explain the disparity.

>

>> >

>

>> > The newly discovered autism

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=11p54fant/ * " >http:/ www.time. com/time/ topics/autism/ 0,30939,,

> 00.html>

>

>> > <http:/www.time. com/time/ topics/autism/ 0,30939,, 00.html>

>

>> > -risk gene, identified by authors as CACNA1G, is more common in boys than

> in

>

>> > girls (why that's so is still not clear), and the authors suggest it plays

> a

>

>> > role in boys' increased risk of the developmental disorder. CACNA1G, which

>

>> > sits on chromosome 17, amid other genes that have been previously linked

> to

>

>> > autism, is responsible for regulating the flow of calcium into and out of

>

>> > cells. Nerve cells in the brain rely on calcium to become activated, and

>

>> > research suggests that imbalances in the mineral can result in the

>

>> > overstimulation of neural connections and create developmental problems,

>

>> > such as autism and even epilepsy, which is also a common feature of

> autism.

>

>> > (

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=12kvbetpo/ *http:/www. time.com/ time/specials/ packages/

> article/0, 2880

>

>> > 4,1893554_1893556, 00.html> See six tips for traveling with an autistic

>

>> > child.)

>

>> >

>

>> > " Our current theories about autism suggest that the disorder is related to

>

>> > overexcitability at nerve endings, " says Geri Dawson, chief science

> officer

>

>> > of Autism Speaks, an advocacy group that provided the genetic data used by

>

>> > the study's authors. " It's interesting to see that the gene they

> identified

>

>> > appears to modulate excitability of neurons. "

>

>> >

>

>> > For the new study, researchers at the University of California, Los

> Angeles

>

>> > (UCLA), combed the genetic database of the Autism Genetic Resource

> Exchange

>

>> > (AGRE), a resource of DNA from 2,000 families with at least one autistic

>

>> > child. The scientists focused on the more than 1,000 genetic samples of

>

>> > families in which at least one son was affected by the disorder, prompted

> by

>

>> > the results of an earlier study using the same database, which identified

> a

>

>> > rich autism-related genetic region on chromosome 17 that contained genetic

>

>> > variants more common in boys than in girls. While nearly 40% of the

> general

>

>> > population has the most common form of CACNA1G, one variant of the gene

> was

>

>> > more prevalent in autistic boys, researchers found. " There is a strong

>

>> > genetic signal in this region, " says Dr. Geschwind, director of

>

>> > UCLA's Center for Autism Research and Treatment and one of the study's

>

>> > co-authors. " But this gene doesn't explain all of that signal or even half

>

>> > of it. What that means is that there are many more genes in this region

>

>> > contributing to autism. " (

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=11pkhspim/ * " >http:/ www.time. com/time/ photoessays/

> 2006/autismschoo l/>

>

>> > <http:/www.time. com/time/ photoessays/ 2006/autismschoo l/>

>

>> > See pictures of inside a school for autistic children.)

>

>> >

>

>> > That's not surprising for a disorder as complex as autism - actually, a

>

>> > spectrum of developmental disorders involving impairment in language,

> social

>

>> > behavior and certain physical behaviors - with symptoms that range widely

> in

>

>> > number and severity. So far, studies have linked a handful of genes, all

> of

>

>> > which play a role in the way

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=1225o0np0/ *http:/www. time.com/ time/magazine/ article/0,

> 9171,1191843,

>

>> > 00.html> nerve cells connect and communicate, with autism spectrum

>

>> > disorders. It's likely not only that a large number of genes contribute to

>

>> > the disorder, but also that a different combination of genes - as well as

>

>> > unique interactions between genes and environment - are responsible for

> each

>

>> > individual case of autism.

>

>> >

>

>> > So it's certainly a daunting challenge to begin teasing out the individual

>

>> > genes that may contribute to autism, as the UCLA team has with CACNA1G,

> but

>

>> > databases like AGRE make the job slightly easier. The next step will be to

>

>> > try to use known autism genes to help develop screening tools or early

>

>> > interventions. " We are going to have a much better understanding of the

>

>> > causes of autism over the next five to 10 years, " says Dawson. " We're in a

>

>> > period of great discovery. "

>

>> >

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=11cm8egb0/ * " >http:/ www.time. com/time/ picturesofthewee k>

>

>> > <http:/www.time. com/time/ picturesofthewee k> See TIME's

>

>> > Pictures of the Week.

>

>> >

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=12k70eqgn/ *http:/www. time.com/ time/specials/ packages/

> article/0, 2880

>

>> > 4,1847616_1847615, 00.html> See the most common hospital mishaps.

>

>> >

>

>> > View this article on

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=12s931o9q/ *http:/www. time.com/ time/health/ article/0,

> 8599,1899756, 00

>

>> > .html?xid=rss- fullhealthsci- > Time.com

>

>> >

>

>> > Related articles on Time.com:

>

>> >

>

>> > *

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=13387bjf5/ *http:/www. time.com/ time/health/ article/0,

> 8599,1894409, 00

>

>> > .html?xid=feed- -full- health-related> Autism Linked to Genes That

> Govern

>

>> > How the Brain Is Wired

>

>> > *

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=133stcntl/ *http:/www. time.com/ time/health/ article/0,

> 8599,1821595, 00

>

>> > .html?xid=feed- -full- health-related> New Clues to Autism's Cause

>

>> > *

>

>> > <http://us.rd. / dailynews/ time/hl_time/ storytext/

> 08599189975600/ 3207

>

>> > 3688/SIG=1339lkvp2/ *http:/www. time.com/ time/health/ article/0,

> 8599,1895357, 00

>

>> > .html?xid=feed- -full- health-related> Researchers Find First Signs

> of

>

>> > Autism Even in Infancy

>

>> >

>

>> >

[Guest guest]

With some of the calcium dysfunction, I've actually wondered if going dairy free

helps partly by reducing calcium.  Neither of my kids did well at all when I was

believing they needed calcium supplements.

I also wonder if the supplement forms just aren't what our bodies use best.  If

I get worried about calcium, homemade bone broths are supposed to be about as

perfect a source as we could get next to dairy.

HTH-

________________________________

From: Houston <m_jhouston333@...>

Sent: Wednesday, May 20, 2009 1:28:55 PM

Subject: Re: A Genetic Clue to Why Autism Affects Boys More

What role does calcium supplementation play?  Can more calcium in the child's

diet help?

From: Neno/Natasa <nenodalmaholidays (DOT) co.uk>

Subject: Re: A Genetic Clue to Why Autism Affects Boys More

groups (DOT) com

Date: Wednesday, May 20, 2009, 6:09 PM

>

>

> oh there. I was wondering why my site was getting so many hits today, people

> googling autism and calcium like mad.

>

> this research is more or less flaggin the dead horse (unless they take it in a

> useful direction now, which I highly doubt). They better look into how

> pathogens screw up calcium signalling, and also how male hormones in asd boys

> influence those pathways. And how female hormones stop calcium excesses. Which

> is why the different rates in boys and girls imo

>

> sorry for the rant, just hate to see research money being wasted.

>

> Natasa

> http://autismcalciu mchannelopathy. com/Infectious_ Agents.html#

>

>

>

> Here is something published in Time . what do we make of this?

>

> A Genetic Clue to Why Autism Affects Boys More

>

> TIME

>

> By ALICE PARK Alice Park - Wed May 20, 6:20 am ET

>

> Among the many mysteries that befuddle autism researchers: why the disorder

> affects boys four times more often than girls. But in new findings reported

> online today by the journal Molecular Psychiatry, researchers say they have

> found a genetic clue that may help explain the disparity.

>

> The newly discovered autism

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=11p54fant/ * " >http:/ www.time. com/time/ topics/autism/ 0,30939,,

00.html>

> <http:/www.time. com/time/ topics/autism/ 0,30939,, 00.html>

> -risk gene, identified by authors as CACNA1G, is more common in boys than in

> girls (why that's so is still not clear), and the authors suggest it plays a

> role in boys' increased risk of the developmental disorder. CACNA1G, which

> sits on chromosome 17, amid other genes that have been previously linked to

> autism, is responsible for regulating the flow of calcium into and out of

> cells. Nerve cells in the brain rely on calcium to become activated, and

> research suggests that imbalances in the mineral can result in the

> overstimulation of neural connections and create developmental problems,

> such as autism and even epilepsy, which is also a common feature of autism.

> (

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=12kvbetpo/ *http:/www. time.com/ time/specials/ packages/ article/0,

2880

> 4,1893554_1893556, 00.html> See six tips for traveling with an autistic

> child.)

>

> " Our current theories about autism suggest that the disorder is related to

> overexcitability at nerve endings, " says Geri Dawson, chief science officer

> of Autism Speaks, an advocacy group that provided the genetic data used by

> the study's authors. " It's interesting to see that the gene they identified

> appears to modulate excitability of neurons. "

>

> For the new study, researchers at the University of California, Los Angeles

> (UCLA), combed the genetic database of the Autism Genetic Resource Exchange

> (AGRE), a resource of DNA from 2,000 families with at least one autistic

> child. The scientists focused on the more than 1,000 genetic samples of

> families in which at least one son was affected by the disorder, prompted by

> the results of an earlier study using the same database, which identified a

> rich autism-related genetic region on chromosome 17 that contained genetic

> variants more common in boys than in girls. While nearly 40% of the general

> population has the most common form of CACNA1G, one variant of the gene was

> more prevalent in autistic boys, researchers found. " There is a strong

> genetic signal in this region, " says Dr. Geschwind, director of

> UCLA's Center for Autism Research and Treatment and one of the study's

> co-authors. " But this gene doesn't explain all of that signal or even half

> of it. What that means is that there are many more genes in this region

> contributing to autism. " (

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=11pkhspim/ * " >http:/ www.time. com/time/ photoessays/

2006/autismschoo l/>

> <http:/www.time. com/time/ photoessays/ 2006/autismschoo l/>

> See pictures of inside a school for autistic children.)

>

> That's not surprising for a disorder as complex as autism - actually, a

> spectrum of developmental disorders involving impairment in language, social

> behavior and certain physical behaviors - with symptoms that range widely in

> number and severity. So far, studies have linked a handful of genes, all of

> which play a role in the way

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=1225o0np0/ *http:/www. time.com/ time/magazine/ article/0,

9171,1191843,

> 00.html> nerve cells connect and communicate, with autism spectrum

> disorders. It's likely not only that a large number of genes contribute to

> the disorder, but also that a different combination of genes - as well as

> unique interactions between genes and environment - are responsible for each

> individual case of autism.

>

> So it's certainly a daunting challenge to begin teasing out the individual

> genes that may contribute to autism, as the UCLA team has with CACNA1G, but

> databases like AGRE make the job slightly easier. The next step will be to

> try to use known autism genes to help develop screening tools or early

> interventions. " We are going to have a much better understanding of the

> causes of autism over the next five to 10 years, " says Dawson. " We're in a

> period of great discovery. "

>

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=11cm8egb0/ * " >http:/ www.time. com/time/ picturesofthewee k>

> <http:/www.time. com/time/ picturesofthewee k> See TIME's

> Pictures of the Week.

>

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=12k70eqgn/ *http:/www. time.com/ time/specials/ packages/ article/0,

2880

> 4,1847616_1847615, 00.html> See the most common hospital mishaps.

>

> View this article on

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=12s931o9q/ *http:/www. time.com/ time/health/ article/0,

8599,1899756, 00

> .html?xid=rss- fullhealthsci- > Time.com

>

> Related articles on Time.com:

>

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=13387bjf5/ *http:/www. time.com/ time/health/ article/0,

8599,1894409, 00

> .html?xid=feed- -full- health-related> Autism Linked to Genes That Govern

> How the Brain Is Wired

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=133stcntl/ *http:/www. time.com/ time/health/ article/0,

8599,1821595, 00

> .html?xid=feed- -full- health-related> New Clues to Autism's Cause

> *

> <http://us.rd. / dailynews/ time/hl_time/ storytext/ 08599189975600/

3207

> 3688/SIG=1339lkvp2/ *http:/www. time.com/ time/health/ article/0,

8599,1895357, 00

> .html?xid=feed- -full- health-related> Researchers Find First Signs of

> Autism Even in Infancy

>

>