Guest guest Posted April 12, 2000 Report Share Posted April 12, 2000 It proves that food moving through your intestines causes the arthritis! (Either by leaking through the lining, or by rupturing the lining which lets the bacteria through). -Mike- rheumatic Leaky gut Does that mean it's from leaky gut? I once saw a study where they were postulating that people with arthritis have very thin intestinal linings and thus the leaky gut. What does this IV test prove? _________________________ Interestingly enough - this has been tested! People with psoriatic arthritis see almost complete remission on IV feeding! It's just hard to live life that way... ------------------------------------------------------------------------ Get paid for the stuff you know! Get answers for the stuff you dont. And get $10 to spend on the site! 1/2200/0/_/532797/_/955558727/ ------------------------------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 12, 2000 Report Share Posted April 12, 2000 Hi : You are absolutely right that if you have food allergy then you have a leaky gut and the gut needs to be addressed before anything else goes right. I have allergies and a leaky gut, yeast infection and klebsiella (spelling?) and my doctor treated me for the leaky gut, yeast and kleb and my allergies are so much better. I am at present doing an immuno therapy and I feel pretty good. Tomorrow is my next treatment to desensitize me and I sure hope that it works just as well as the first one did. Mado Re: rheumatic Leaky gut > I kind of have the feeling that if you have a food allergy then you have a >leaky gut problem. I have no scientific basis for my opinion, its just a > " gut " feeling. > Im not sure if curing your leaky gut or eliminating allergens would cure >your arthritis, but i feel it can help with severity and flare ups. > > > > rheumatic Leaky gut >> >> >> Does that mean it's from leaky gut? I once saw a study where they were >> postulating that people with arthritis have very thin intestinal linings >and >> thus the leaky gut. What does this IV test prove? >> >> _________________________ >> Interestingly enough - this has been tested! People with psoriatic >> arthritis see almost complete remission on IV feeding! It's just hard to >> live life that way... >> >> ------------------------------------------------------------------------ >> Get paid for the stuff you know! >> Get answers for the stuff you dont. And get $10 to spend on the site! >> 1/2200/0/_/532797/_/955558727/ >> ------------------------------------------------------------------------ >> >> >> >> >> ------------------------------------------------------------------------ >> Get paid for the stuff you know! >> Get answers for the stuff you don't. And get $10 to spend on the site! >> 1/2200/0/_/532797/_/955559995/ >> ------------------------------------------------------------------------ >> >> >> > > >------------------------------------------------------------------------ >Free E-Cards, Screensavers, and Digital Pictures! >Corbis.com: >1/3358/0/_/532797/_/955569976/ >------------------------------------------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 12, 2000 Report Share Posted April 12, 2000 I kind of have the feeling that if you have a food allergy then you have a leaky gut problem. I have no scientific basis for my opinion, its just a " gut " feeling. Im not sure if curing your leaky gut or eliminating allergens would cure your arthritis, but i feel it can help with severity and flare ups. rheumatic Leaky gut > > > Does that mean it's from leaky gut? I once saw a study where they were > postulating that people with arthritis have very thin intestinal linings and > thus the leaky gut. What does this IV test prove? > > _________________________ > Interestingly enough - this has been tested! People with psoriatic > arthritis see almost complete remission on IV feeding! It's just hard to > live life that way... > > ------------------------------------------------------------------------ > Get paid for the stuff you know! > Get answers for the stuff you dont. And get $10 to spend on the site! > 1/2200/0/_/532797/_/955558727/ > ------------------------------------------------------------------------ > > > > > ------------------------------------------------------------------------ > Get paid for the stuff you know! > Get answers for the stuff you don't. And get $10 to spend on the site! > 1/2200/0/_/532797/_/955559995/ > ------------------------------------------------------------------------ > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2001 Report Share Posted August 1, 2001 Gwen, Doing a www.google.com search on " leaky gut " (in quotation marks) will bring up 7,220 references. The following web pages are listed near the top of the search results and will give you a start: http://osiris.sunderland.ac.uk/autism/gut.htm http://www.nutri-notes.com/marapr98_simple.htm http://www.lovelyhealth.com/LGS.htm http://www.healthy.net/asp/templates/article.asp?PageType=Article & ID=425 For a more refined search combining leaky gut with arthritis (for example), do a www.google.com search on + " leaky gut " +arthritis (typing the quotation marks and plus signs into the search field). The quotation marks define a set of words that must appear together in the page, and the + signs mean that only pages which incorporate the search term will be brought up. Doing a search on " leaky gut syndrome " (in quotation marks) will bring up 3,780 pages. Sincerely, Harald At 11:05 PM 07/31/2001 -0600, Gwen Armstrong wrote: >Hi Group >Could someone give me some references /sites/ articles on " leaky gut >syndrome " please? >I know I have seen messages from various group members about it but of >course until you have the problem , you don't pay close attention. >Thanks in advance >Gwen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 19, 2003 Report Share Posted December 19, 2003 Also, will the leaky gut infect other organs like stomach and kidneys? --- In , " netbaroque " <netbaroque@y...> wrote: > If I do have yeast and bacteria problems in my gut, and I have taken > GSE and probiotics those kind, as well as on gcfc-like diet, will the > leaky gut recover itself, or should I take any med or supplement to > heal it? > > Thanks Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 19, 2003 Report Share Posted December 19, 2003 Digestiv enzymes will help it heal, see www.enzymestuff.com MAndi in UK > If I do have yeast and bacteria problems in my gut, and I have taken > GSE and probiotics those kind, as well as on gcfc-like diet, will the > leaky gut recover itself, or should I take any med or supplement to > heal it? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 20, 2003 Report Share Posted December 20, 2003 > If I do have yeast and bacteria problems in my gut, and I have taken > GSE and probiotics those kind, as well as on gcfc-like diet, will the > leaky gut recover itself, or should I take any med or supplement to > heal it? For some people it may heal itself, but for my son he needed the metals removed. Enzymes can help also http://www.houstonni.com/ >>Also, will the leaky gut infect other organs like stomach and kidneys? For my son, it apparently affected his brain and immune system. Might not have been " leaky gut " which affected those areas, might have been metal toxicity which *caused* leaky gut and the other issues. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 24, 2003 Report Share Posted December 24, 2003 People often take glutamine powder or other stuff to heal it. Usually taken between meals. 1 tsp to 1 tbsp glutamine. Andy . . . . . .. . . > If I do have yeast and bacteria problems in my gut, and I have taken > GSE and probiotics those kind, as well as on gcfc-like diet, will the > leaky gut recover itself, or should I take any med or supplement to > heal it? > > Thanks Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2006 Report Share Posted August 14, 2006 Hi Lizbeth; I have Celiac disease besides the SD and it most likely caused the Leaky Gut and possibly the SD.He is a wee bit of info that may clarify things. Lynne G. http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=Cu\ rrent & message=63589 <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589> ------------------------------------------------------------------------ ------------------------------------------------------------------------ Natural Approaches to Leaky Gut/Worth Reading [ View Thread <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#followups> ] [ Post Reply <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#postfp> ] [ Admin <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & admin=63589> ] [ Return to Main List <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent> ] [ Help <http://www.roadback.org/eboard30/help.htm> ] [ Return to Main Index tree <http://www.roadback.org/cgi-bin/eboard30/index.cgi?board=Main> ] Posted by A Friend on Sat - Aug 5 - 9:43pm: [This is a topic we need to thoroughly understand. The consequences of having these problems can be great. AF] http://www.positivehealth.com/test/articles.asp?i=1748 & b=1 Natural Approaches to Leaky Gut by Neil Wootten (more info) listed in colon health originally published in issue 111 - May 2005 Leaky Gut sounds a bit messy, but actually it is not at all. It occurs where there is hyperpermeability of the gut membrane. The gut should, indeed, be permeable to a certain degree to allow nutrients through. Ordinarily, the large intestine acts like a one-way protective sieve that filters out certain food molecules and peptides. In the case of Leaky Gut, the one-way gate of the gut open too wide, allowing an increase in peptide molecules and pathogens, which attract certain cells of the immune system called phagocytes, letting them pass through the gut wall into the intestine. It is the presence of these phagocytes that causes an inflammatory reaction in the gut wall. I liken it to sieving flour. If you are sieving flour for baking, you need a fine sieve that will allow the fine flour through and keep the lumps out. This is how the gut operates normally; it allows molecules of nutrients through, but stops larger molecules and pathogens getting through into the bloodstream. When the gut becomes too permeable, the effect is like trying to sieve flour with a colander - many more lumps get through. This equates to undigested molecules and particles of food, along with pathogens getting into the body and setting off an immune reaction. Such foreign bodies, circulating in the blood, will sensitize the immune system and often cause adverse reactions to food, showing up as either an allergy or intolerance. These, in turn, can result in a bewildering array of symptoms those with chronic illnesses may be able to relate to: .. Fatigue and malaise .. Arthritic conditions .. Painful muscle conditions .. Fevers of unknown origin .. Food intolerances .. Abdominal pain .. Abdominal distension .. Diarrhoea .. Skin rashes .. Toxic feelings .. 'Brain Fog' .. Shortness of breath .. Poor exercise tolerance Also, whenever this permeability is increased, IBS gets worse.1 How Is It Caused? Many people suffer from leaky gut and do not realize it. A Leaky Gut can be caused by anything that damages the lining of the intestine - infectious microbes, such as bacteria and parasites, a Candida albicans overgrowth, allergies or even certain prescription drugs, such as antibiotics and particularly Non-Steroidal Anti-Inflammatory Drugs or NSAIDs.2 This last is a phenomenon that is a well-known and studied side effect of NSAIDs. Even single doses of aspirin or of indomethacin increase cellular permeability, in part by inhibiting the synthesis of the protective fatty acid prostaglandin. Long-term exposure to NSAIDs leaves the gut highly inflamed and permeable. Whatever causes leaky gut, once the condition has developed, it can be self- perpetuating. The relationship between food sensitivities and the leaky gut is both complex and circular. In experimental trials reported in Allergy in 1989, children and adults with eczema, urticaria or asthma triggered by food allergy show that they have higher gut permeability than those who don't have these conditions. This indicates that allergies and food sensitivities may be caused by an over permeable gut. Interestingly, gut permeability also sharply increases whenever allergic subjects are exposed to allergenic foods. In all probability what this indicates is that an increase in intestinal permeability is both important as a cause of food allergy and also the result of food allergy. How Does It Affect Us? There are a number of physical conditions that are well-recognized by mainstream allopathic medicine as having a relationship to Leaky Gut. These include inflammatory and infectious bowel diseases, chronic inflammatory joint diseases,3 skin conditions like acne, psoriasis and dermatitis,4 and many diseases triggered by food allergy or specific food intolerance, including eczema, urticaria and irritable bowel syndrome,5 and even chronic hepatitis. Leaky Gut is also very much associated with Candida. The Candida organism can metamorphose in the gut, changing from a simple yeast cell into a much more harmful 'mycelial' fungal form. Under the microscope, the cell appears to sprout roots and branches; these burrow their way into the walls of the intestine, and ultimately can spread throughout the body, with potentially widespread adverse effect. The National Candida Society notes that up to 16 million people in the UK may be affected by Candida-related problems. Increased gut permeability may play a primary role in causing these diseases, or it may be a consequence of it. But by causing an immune system reaction, liver dysfunction and pancreatic insufficiency, it creates a vicious cycle. In most cases, the role of increased intestinal permeability in these sorts of patients often goes undiagnosed and unrecognized. One of the latest and most interesting theories comes from health writer Susie Cornell, who postulates that Leaky Gut probably plays a central role in the development of Multiple Sclerosis (MS). In one research project of 40 MS patients, all were found to have a number of nutritional deficiencies, even among those taking supplements. The patients show particular deficiencies of magnesium, manganese, selenium, zinc and mostly all of the B vitamins. This is quite common with Leaky Gut patients. Even patients who supplement with these specific nutrients remain deficient in them. Because different parts of the intestinal wall absorb different nutrients, damage to the wall in one area may cause poor absorption of one particular nutrient, says Cornell. This is why a patient might show one single deficiency rather than complete malnutrition. The symptoms of B12 deficiency and magnesium deficiency include fatigue, irritability, nervous system disorders, tingling and numbness in fingers and toes and even balance problems. These are among the symptoms that have collectively been termed 'MS'. You may have noticed that some of these symptoms are shared with Leaky Gut. Testing for Leaky Gut Thankfully, it is a relatively simple exercise to test for Leaky Gut. A safe, non-invasive and inexpensive method called the Lactulose/Mannitol test has been developed to measure small intestinal permeability and also test how well a treatment is working. Claude Andre, the leading French research worker in this area, says that measuring gut permeability is a sensitive and practical screening test for detecting food allergy and responsiveness to treatment. In Andre's protocol, patients ingest five grams each of the innocuous sugars lactulose and mannitol. These sugars are not metabolized by humans, and the amount absorbed is fully excreted in the urine within six hours. Mannitol, a monosaccharide, is passively transported through the intestinal cell walls; the average absorption is 14% of the administered dose. In contrast, the intestinal tract blocks lactulose, a dissaccharide; less than one per cent of the administered dose is normally absorbed. The level of both lactulose and mannitol recovered in urine is then measured. The normal ratio of lactulose/mannitol recovered in urine is less than 0.03. A higher ratio signifies too much absorption of lactulose and therefore a gut that 'leaks'. If your test shows you have abnormal fasting permeability, you have more gut lining damage than patients with normal fasting permeability and will take longer to heal. If you come up with a normal Lactulose/Mannitol test result, repeat it after you've eaten a meal of your most common foods. If the test meal produces an increase in lactulose excretion (which signifies a leaky gut) or a decrease in mannitol excretion (signifying malabsorption of food), it's likely that you have specific food intolerances. Further testing for food allergy is then warranted. Once you've been maintained on a stable elimination diet for four weeks, you should repeat the lactulose/mannitol challenge after a test meal with the foods permitted on the elimination diet. A normal result will assure you that all major allergens have been identified. An abnormal result indicates that more detective work is needed. In the case of relatively mild celiac disease or inflammatory bowel disease, your mannitol absorption may not be affected but the lactulose absorption will be elevated. A recent study published in the Lancet found that the lactulose/ mannitol ratio was an accurate predictor of a relapse in patients who'd previously suffered from Crohn's disease.1 If your initial fasting lactulose is elevated, or if the initial fasting lactulose/mannitol ratio is elevated, your practitioner should also consider the possibility of mild bowel disease or gluten allergy. We may have to entirely re-think what we term disease as not something we necessarily catch, but something predominantly under our control, caused by a chronic breakdown of digestive processes. It may be that symptoms we group together into a classifiable disease or syndrome may be no more than the manifestation of one or more nutrient deficiencies, or the results of a hyperpermeable gut. This would mean that the most important supplements we take may not necessarily be vitamins and minerals themselves, but all the digestive enzymes and substances which ensure that our gut properly absorbs and distributes what we eat. How To Correct It? It is quite possible to cure a Leaky Gut with a nutrient dense diet and appropriate supplements. Many natural substances help repair the intestinal mucosal surface or support the liver when it becomes challenged and stressed by toxins. We have found the swiftest approach, however, to be the use of Colostrum. Professor Playford of Imperial College and Hammersmith Hospital conducted trials on indomethacin-induced gut hyperpermeability, and noted that Colostrum healed leaky gut even while the gut was being attacked by this NSAID.6 A key growth factor in Colostrum is Epidermal Growth Factor (EGF), a polypeptide that stimulates growth and repair of epithelial tissue that is widely distributed in the body. Purified EGF has been shown to heal ulceration of the small intestine.7 He noted that the growth factors contained in Colostrum, including EGF, repaired damage to the gut, and should also work to improve inflammatory and ulcerative conditions of the gut. Colostrum also contains Secretory IgA, which is essential to the maintenance of the integrity of the mucosal lining of the gut. Vitamin and mineral supplements should include all the B vitamins, vitamin A, C and E, zinc, selenium, molybdenum, manganese and magnesium. Because of the association between increased gut permeability and pancreatic dysfunction, pancreatic enzymes may also be needed. It is clearly better, if possible, to avoid drugs that damage the gut. This is not essential if co-dosing with Colostrum, as it heals the gut and keeps permeability at normal levels. One would think that beneficial bacteria might have a role to play in achieving and maintaining normal gut permeability levels. Currently Lactobacillus caseii var GG, a strain of lactobacillus isolated and purified in Finland, has been shown to be effective in improving the gut permeability when this was associated with a rotavirus infection.8 Most practitioners recommend glutamine, the amino acid needed for the maintenance of intestinal metabolism, structure and function for Leaky Gut. It has been shown to reverse all the gut abnormalities in patients fed intravenously. Glutamine also repairs gut lining damage caused by chemotherapy or radiation,9 although we have found clinically that it is much slower to take effect than Colostrum. Supporting the Liver Because the effects of Leaky Gut greatly increase the load on the liver, it is vital to support proper liver function. The liver of leaky gut patients works overtime to remove oversized food molecules and to oxidize gut toxins, causing increased production of free radicals. This, in turn, causes damage to liver cells and sends by-products into bile, producing toxic bile capable of damaging bile ducts and backing up into the pancreas. Indeed, this may be the cause of chronic pancreatic disease. In attempting to rectify all this, the liver depletes its reserves of certain amino acids.10 This is similar to the process that occurs in liver diseases caused by alcohol. A lowered level of liver glutathione is a common occurrence in leaky gut syndromes, and contributes to liver dysfunction and liver necrosis among alcoholics, and immune impairment in patients with AIDS. The most effective way to raise liver glutathione is to take its dietary precursors, cysteine or methionine. A useful supplement to take is N-acetyl cysteine which helps the body to synthesize glutathione at the same time as giving protection from the toxins. Take essential fatty acids (EFAs), particularly gammalinolenic acid (GLA). In laboratory experiments, fish oil was able to prevent intestinal mucosal injury produced by methotrexate and protect the body from the toxins produced in the gut.11 Take these in their most concentrated and physiologically active form to avoid exposure to large quantities of polyunsaturated fatty acids. If you are supplementing with dietary fibre, make sure you are taking hypoallergenic insoluble fibre and watch the amount, as too much may increase gut permeability.12 A large proportion of the population have a kind of low-level dysfunction in the gut, called dysbiosis. This is caused by an imbalance of non-beneficial (bad bacteria or yeast) organisms which mainly do their damage by altering the metabolic or immune responses of the body. The situation where the immune system begins to react to (and destroy) normal gut flora is one example that has been implicated in the development of conditions such as Crohn's disease and ankylosing spondylitis. Recent research suggests that this kind of gut bacterial sensitization is an early complication of altered permeability. Leaky Gut is relatively common, and when one looks at the possible causes, one can easily understand why. Widely prescribed medications can cause widespread problems. Yet Leaky Gut is also relatively easy to diagnose with a simple Lactulose/Mannitol test, and also fairly straightforward to correct. Once the Leaky Gut is dealt with, one should find a lessening of a myriad of puzzling symptoms. It is important once the gut is restored to a normal permeability to avoid the very things that caused the hyperpermeability in the first place. Equally important is the consumption of a diet and a supplement regime that will help maintain the health of the gut wall. Remember, you are not what you eat; rather you are what you absorb! References 1. Wyatt J, Vogelsang H, Hubl W, Waldhoer T and Lochs H. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet. 5: 341 (8858):1437-9. June 1993. 2. RT, Rooney PJ, DB, Bienenstock J and Goodacre RL. Increased intestinal permeability in patients with rheumatoid arthritis: a side-effect of oral nonsteroidal anti-inflammatory drug therapy? Br J Rheumatol. 26(2): 103-7. April 1987. 3. Rooney PJ, RT and Buchanan WW. A short review of the relationship between intestinal permeability and inflammatory joint disease. Clin Exp Rheumatol. 8(1): 75-83. Review. Jan-Feb 1990. 4. Juhlin L and Vahlquist C. The influence of treatment on fibrin microclot generation in psoriasis. Br J Dermatol. 108(1): 33-7. Jan 1983. 5. PG, Lessof MH, Baker RW, Ferrett J and Mac DM. Intestinal permeability in patients with eczema and food allergy. Lancet. 13: 1(8233):1285-6. June 1981. 6. Playford RJ, Mac CE, Calnan DP, Floyd DN, Podas T, W, Wicks AC, Bashir O and Marchbank T. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond). 100(6): 627-33. June 2001. 7. Playford RJ, Woodman AC, P, Watanapa P, Vesey D, Deprez PH, on RC and Calam J. Effect of luminal growth factor preservation on intestinal growth. Lancet. 3: 341(8849):843-8. April 1993. 8. Siitonen S, Vapaatalo H, Salminen S, Gordin A, Saxelin M, Wikberg R and Kirkkola AL. Effect of Lactobacillus GG yoghurt in prevention of antibiotic associated diarrhoea. Ann Med. 22(1): 57-9. Feb 1990. 9. Klimberg VS, Salloum RM, Kasper M, Plumley DA, Dolson DJ, Hautamaki RD, Mendenhall WR, Bova FC, Bland KI, Copeland EM third, et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg. 125(8): 1040-5. Aug 1990. 10. Whitcomb DC and Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA. 21: 272(23):1845-50. Dec 1994. 11. Vanderhoof JA, Blackwood DJ, Mohammadpour H and Park JH. Effect of dietary menhaden oil on normal growth and development and on ameliorating mucosal injury in rats. Am J Clin Nutr. 54(2): 346-50. Aug 1991. 12. Gyory CP and Chang GW. Effects of bran, lignin and deoxycholic acid on the permeability of the rat cecum and colon. J Nutr. 113(11): 2300-7. Nov 1983. ------------------------------------------------------------------------ View Thread NEW Natural Approaches to Leaky Gut/Worth Reading - Posted by A Friend - Sat - Aug 5 - 9:43pm ------------------------------------------------------------------------ Post Reply Name: Email (Opt.): Topic: Message: Link URL (Opt.): Link Title (Opt.): Image URL (Opt.): [ View Thread <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#followups> ] [ Post Reply <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#postfp> ] [ Admin <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & admin=63589> ] [ Return to Main List <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent> ] [ Help <http://www.roadback.org/eboard30/help.htm> ] Lisbeth wrote: > Who's tried what successfully? > > Am I correct in thinking that treatment is contradictory for anyone > with diverticular disease and diverticulitus? > > Geoff?????? > > Why is nothing ever straight forward !! :-)) > > Huggles, > Lisbeth > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2006 Report Share Posted August 14, 2006 Lynne, you're connecting your SD to Celiac? Leaky gut? I'm keeping an open mind about the cause(s) of SD, at least until somebody publishes THE definitive study in a major journal or Geraldo discovers the truth.....live. The problem with Wootten is the same as with many others.....acceptance of their hypothesis is directly related to the commercial (and timely) success of their revolutionary products. Maybe the guy is the Einstein of the intestinal world, but for me, he's got just a little bit of a credibility bump in the road as long as he profits. Relatively speaking, Albert received only $28K for his Nobel theory and his ex took all of that and more. Jeff ----Original Message Follows---- From: lynneandsantos <lynneandsantos@...> Reply-rheumatic rheumatic Subject: Re: rheumatic Leaky gut Date: Mon, 14 Aug 2006 10:18:22 -0400 Hi Lizbeth; I have Celiac disease besides the SD and it most likely caused the Leaky Gut and possibly the SD.He is a wee bit of info that may clarify things. Lynne G. http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=Cu\ rrent & message=63589 <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2006 Report Share Posted August 14, 2006 THANK THANK THANK YOU Lynne This is excellent and exactly what I was after..!! Have you tried any of their suggestions? Really appreciate your help. ! Huggles, Lisbeth Re: rheumatic Leaky gut Hi Lizbeth; I have Celiac disease besides the SD and it most likely caused the Leaky Gut and possibly the SD.He is a wee bit of info that may clarify things. Lynne G. http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=Cu\ rrent & message=63589 <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589> ---------------------------------------------------------- ---------------------------------------------------------- Natural Approaches to Leaky Gut/Worth Reading [ View Thread <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#followups> ] [ Post Reply <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#postfp> ] [ Admin <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & admin=63589> ] [ Return to Main List <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent> ] [ Help <http://www.roadback.org/eboard30/help.htm> ] [ Return to Main Index tree <http://www.roadback.org/cgi-bin/eboard30/index.cgi?board=Main> ] Posted by A Friend on Sat - Aug 5 - 9:43pm: [This is a topic we need to thoroughly understand. The consequences of having these problems can be great. AF] http://www.positivehealth.com/test/articles.asp?i=1748 & b=1 Natural Approaches to Leaky Gut by Neil Wootten (more info) listed in colon health originally published in issue 111 - May 2005 Leaky Gut sounds a bit messy, but actually it is not at all. It occurs where there is hyperpermeability of the gut membrane. The gut should, indeed, be permeable to a certain degree to allow nutrients through. Ordinarily, the large intestine acts like a one-way protective sieve that filters out certain food molecules and peptides. In the case of Leaky Gut, the one-way gate of the gut open too wide, allowing an increase in peptide molecules and pathogens, which attract certain cells of the immune system called phagocytes, letting them pass through the gut wall into the intestine. It is the presence of these phagocytes that causes an inflammatory reaction in the gut wall. I liken it to sieving flour. If you are sieving flour for baking, you need a fine sieve that will allow the fine flour through and keep the lumps out. This is how the gut operates normally; it allows molecules of nutrients through, but stops larger molecules and pathogens getting through into the bloodstream. When the gut becomes too permeable, the effect is like trying to sieve flour with a colander - many more lumps get through. This equates to undigested molecules and particles of food, along with pathogens getting into the body and setting off an immune reaction. Such foreign bodies, circulating in the blood, will sensitize the immune system and often cause adverse reactions to food, showing up as either an allergy or intolerance. These, in turn, can result in a bewildering array of symptoms those with chronic illnesses may be able to relate to: . Fatigue and malaise . Arthritic conditions . Painful muscle conditions . Fevers of unknown origin . Food intolerances . Abdominal pain . Abdominal distension . Diarrhoea . Skin rashes . Toxic feelings . 'Brain Fog' . Shortness of breath . Poor exercise tolerance Also, whenever this permeability is increased, IBS gets worse.1 How Is It Caused? Many people suffer from leaky gut and do not realize it. A Leaky Gut can be caused by anything that damages the lining of the intestine - infectious microbes, such as bacteria and parasites, a Candida albicans overgrowth, allergies or even certain prescription drugs, such as antibiotics and particularly Non-Steroidal Anti-Inflammatory Drugs or NSAIDs.2 This last is a phenomenon that is a well-known and studied side effect of NSAIDs. Even single doses of aspirin or of indomethacin increase cellular permeability, in part by inhibiting the synthesis of the protective fatty acid prostaglandin. Long-term exposure to NSAIDs leaves the gut highly inflamed and permeable. Whatever causes leaky gut, once the condition has developed, it can be self- perpetuating. The relationship between food sensitivities and the leaky gut is both complex and circular. In experimental trials reported in Allergy in 1989, children and adults with eczema, urticaria or asthma triggered by food allergy show that they have higher gut permeability than those who don't have these conditions. This indicates that allergies and food sensitivities may be caused by an over permeable gut. Interestingly, gut permeability also sharply increases whenever allergic subjects are exposed to allergenic foods. In all probability what this indicates is that an increase in intestinal permeability is both important as a cause of food allergy and also the result of food allergy. How Does It Affect Us? There are a number of physical conditions that are well-recognized by mainstream allopathic medicine as having a relationship to Leaky Gut. These include inflammatory and infectious bowel diseases, chronic inflammatory joint diseases,3 skin conditions like acne, psoriasis and dermatitis,4 and many diseases triggered by food allergy or specific food intolerance, including eczema, urticaria and irritable bowel syndrome,5 and even chronic hepatitis. Leaky Gut is also very much associated with Candida. The Candida organism can metamorphose in the gut, changing from a simple yeast cell into a much more harmful 'mycelial' fungal form. Under the microscope, the cell appears to sprout roots and branches; these burrow their way into the walls of the intestine, and ultimately can spread throughout the body, with potentially widespread adverse effect. The National Candida Society notes that up to 16 million people in the UK may be affected by Candida-related problems. Increased gut permeability may play a primary role in causing these diseases, or it may be a consequence of it. But by causing an immune system reaction, liver dysfunction and pancreatic insufficiency, it creates a vicious cycle. In most cases, the role of increased intestinal permeability in these sorts of patients often goes undiagnosed and unrecognized. One of the latest and most interesting theories comes from health writer Susie Cornell, who postulates that Leaky Gut probably plays a central role in the development of Multiple Sclerosis (MS). In one research project of 40 MS patients, all were found to have a number of nutritional deficiencies, even among those taking supplements. The patients show particular deficiencies of magnesium, manganese, selenium, zinc and mostly all of the B vitamins. This is quite common with Leaky Gut patients. Even patients who supplement with these specific nutrients remain deficient in them. Because different parts of the intestinal wall absorb different nutrients, damage to the wall in one area may cause poor absorption of one particular nutrient, says Cornell. This is why a patient might show one single deficiency rather than complete malnutrition. The symptoms of B12 deficiency and magnesium deficiency include fatigue, irritability, nervous system disorders, tingling and numbness in fingers and toes and even balance problems. These are among the symptoms that have collectively been termed 'MS'. You may have noticed that some of these symptoms are shared with Leaky Gut. Testing for Leaky Gut Thankfully, it is a relatively simple exercise to test for Leaky Gut. A safe, non-invasive and inexpensive method called the Lactulose/Mannitol test has been developed to measure small intestinal permeability and also test how well a treatment is working. Claude Andre, the leading French research worker in this area, says that measuring gut permeability is a sensitive and practical screening test for detecting food allergy and responsiveness to treatment. In Andre's protocol, patients ingest five grams each of the innocuous sugars lactulose and mannitol. These sugars are not metabolized by humans, and the amount absorbed is fully excreted in the urine within six hours. Mannitol, a monosaccharide, is passively transported through the intestinal cell walls; the average absorption is 14% of the administered dose. In contrast, the intestinal tract blocks lactulose, a dissaccharide; less than one per cent of the administered dose is normally absorbed. The level of both lactulose and mannitol recovered in urine is then measured. The normal ratio of lactulose/mannitol recovered in urine is less than 0.03. A higher ratio signifies too much absorption of lactulose and therefore a gut that 'leaks'. If your test shows you have abnormal fasting permeability, you have more gut lining damage than patients with normal fasting permeability and will take longer to heal. If you come up with a normal Lactulose/Mannitol test result, repeat it after you've eaten a meal of your most common foods. If the test meal produces an increase in lactulose excretion (which signifies a leaky gut) or a decrease in mannitol excretion (signifying malabsorption of food), it's likely that you have specific food intolerances. Further testing for food allergy is then warranted. Once you've been maintained on a stable elimination diet for four weeks, you should repeat the lactulose/mannitol challenge after a test meal with the foods permitted on the elimination diet. A normal result will assure you that all major allergens have been identified. An abnormal result indicates that more detective work is needed. In the case of relatively mild celiac disease or inflammatory bowel disease, your mannitol absorption may not be affected but the lactulose absorption will be elevated. A recent study published in the Lancet found that the lactulose/ mannitol ratio was an accurate predictor of a relapse in patients who'd previously suffered from Crohn's disease.1 If your initial fasting lactulose is elevated, or if the initial fasting lactulose/mannitol ratio is elevated, your practitioner should also consider the possibility of mild bowel disease or gluten allergy. We may have to entirely re-think what we term disease as not something we necessarily catch, but something predominantly under our control, caused by a chronic breakdown of digestive processes. It may be that symptoms we group together into a classifiable disease or syndrome may be no more than the manifestation of one or more nutrient deficiencies, or the results of a hyperpermeable gut. This would mean that the most important supplements we take may not necessarily be vitamins and minerals themselves, but all the digestive enzymes and substances which ensure that our gut properly absorbs and distributes what we eat. How To Correct It? It is quite possible to cure a Leaky Gut with a nutrient dense diet and appropriate supplements. Many natural substances help repair the intestinal mucosal surface or support the liver when it becomes challenged and stressed by toxins. We have found the swiftest approach, however, to be the use of Colostrum. Professor Playford of Imperial College and Hammersmith Hospital conducted trials on indomethacin-induced gut hyperpermeability, and noted that Colostrum healed leaky gut even while the gut was being attacked by this NSAID.6 A key growth factor in Colostrum is Epidermal Growth Factor (EGF), a polypeptide that stimulates growth and repair of epithelial tissue that is widely distributed in the body. Purified EGF has been shown to heal ulceration of the small intestine.7 He noted that the growth factors contained in Colostrum, including EGF, repaired damage to the gut, and should also work to improve inflammatory and ulcerative conditions of the gut. Colostrum also contains Secretory IgA, which is essential to the maintenance of the integrity of the mucosal lining of the gut. Vitamin and mineral supplements should include all the B vitamins, vitamin A, C and E, zinc, selenium, molybdenum, manganese and magnesium. Because of the association between increased gut permeability and pancreatic dysfunction, pancreatic enzymes may also be needed. It is clearly better, if possible, to avoid drugs that damage the gut. This is not essential if co-dosing with Colostrum, as it heals the gut and keeps permeability at normal levels. One would think that beneficial bacteria might have a role to play in achieving and maintaining normal gut permeability levels. Currently Lactobacillus caseii var GG, a strain of lactobacillus isolated and purified in Finland, has been shown to be effective in improving the gut permeability when this was associated with a rotavirus infection.8 Most practitioners recommend glutamine, the amino acid needed for the maintenance of intestinal metabolism, structure and function for Leaky Gut. It has been shown to reverse all the gut abnormalities in patients fed intravenously. Glutamine also repairs gut lining damage caused by chemotherapy or radiation,9 although we have found clinically that it is much slower to take effect than Colostrum. Supporting the Liver Because the effects of Leaky Gut greatly increase the load on the liver, it is vital to support proper liver function. The liver of leaky gut patients works overtime to remove oversized food molecules and to oxidize gut toxins, causing increased production of free radicals. This, in turn, causes damage to liver cells and sends by-products into bile, producing toxic bile capable of damaging bile ducts and backing up into the pancreas. Indeed, this may be the cause of chronic pancreatic disease. In attempting to rectify all this, the liver depletes its reserves of certain amino acids.10 This is similar to the process that occurs in liver diseases caused by alcohol. A lowered level of liver glutathione is a common occurrence in leaky gut syndromes, and contributes to liver dysfunction and liver necrosis among alcoholics, and immune impairment in patients with AIDS. The most effective way to raise liver glutathione is to take its dietary precursors, cysteine or methionine. A useful supplement to take is N-acetyl cysteine which helps the body to synthesize glutathione at the same time as giving protection from the toxins. Take essential fatty acids (EFAs), particularly gammalinolenic acid (GLA). In laboratory experiments, fish oil was able to prevent intestinal mucosal injury produced by methotrexate and protect the body from the toxins produced in the gut.11 Take these in their most concentrated and physiologically active form to avoid exposure to large quantities of polyunsaturated fatty acids. If you are supplementing with dietary fibre, make sure you are taking hypoallergenic insoluble fibre and watch the amount, as too much may increase gut permeability.12 A large proportion of the population have a kind of low-level dysfunction in the gut, called dysbiosis. This is caused by an imbalance of non-beneficial (bad bacteria or yeast) organisms which mainly do their damage by altering the metabolic or immune responses of the body. The situation where the immune system begins to react to (and destroy) normal gut flora is one example that has been implicated in the development of conditions such as Crohn's disease and ankylosing spondylitis. Recent research suggests that this kind of gut bacterial sensitization is an early complication of altered permeability. Leaky Gut is relatively common, and when one looks at the possible causes, one can easily understand why. Widely prescribed medications can cause widespread problems. Yet Leaky Gut is also relatively easy to diagnose with a simple Lactulose/Mannitol test, and also fairly straightforward to correct. Once the Leaky Gut is dealt with, one should find a lessening of a myriad of puzzling symptoms. It is important once the gut is restored to a normal permeability to avoid the very things that caused the hyperpermeability in the first place. Equally important is the consumption of a diet and a supplement regime that will help maintain the health of the gut wall. Remember, you are not what you eat; rather you are what you absorb! References 1. Wyatt J, Vogelsang H, Hubl W, Waldhoer T and Lochs H. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet. 5: 341 (8858):1437-9. June 1993. 2. RT, Rooney PJ, DB, Bienenstock J and Goodacre RL. Increased intestinal permeability in patients with rheumatoid arthritis: a side-effect of oral nonsteroidal anti-inflammatory drug therapy? Br J Rheumatol. 26(2): 103-7. April 1987. 3. Rooney PJ, RT and Buchanan WW. A short review of the relationship between intestinal permeability and inflammatory joint disease. Clin Exp Rheumatol. 8(1): 75-83. Review. Jan-Feb 1990. 4. Juhlin L and Vahlquist C. The influence of treatment on fibrin microclot generation in psoriasis. Br J Dermatol. 108(1): 33-7. Jan 1983. 5. PG, Lessof MH, Baker RW, Ferrett J and Mac DM. Intestinal permeability in patients with eczema and food allergy. Lancet. 13: 1(8233):1285-6. June 1981. 6. Playford RJ, Mac CE, Calnan DP, Floyd DN, Podas T, W, Wicks AC, Bashir O and Marchbank T. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond). 100(6): 627-33. June 2001. 7. Playford RJ, Woodman AC, P, Watanapa P, Vesey D, Deprez PH, on RC and Calam J. Effect of luminal growth factor preservation on intestinal growth. Lancet. 3: 341(8849):843-8. April 1993. 8. Siitonen S, Vapaatalo H, Salminen S, Gordin A, Saxelin M, Wikberg R and Kirkkola AL. Effect of Lactobacillus GG yoghurt in prevention of antibiotic associated diarrhoea. Ann Med. 22(1): 57-9. Feb 1990. 9. Klimberg VS, Salloum RM, Kasper M, Plumley DA, Dolson DJ, Hautamaki RD, Mendenhall WR, Bova FC, Bland KI, Copeland EM third, et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg. 125(8): 1040-5. Aug 1990. 10. Whitcomb DC and Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA. 21: 272(23):1845-50. Dec 1994. 11. Vanderhoof JA, Blackwood DJ, Mohammadpour H and Park JH. Effect of dietary menhaden oil on normal growth and development and on ameliorating mucosal injury in rats. Am J Clin Nutr. 54(2): 346-50. Aug 1991. 12. Gyory CP and Chang GW. Effects of bran, lignin and deoxycholic acid on the permeability of the rat cecum and colon. J Nutr. 113(11): 2300-7. Nov 1983. ---------------------------------------------------------- View Thread NEW Natural Approaches to Leaky Gut/Worth Reading - Posted by A Friend - Sat - Aug 5 - 9:43pm ---------------------------------------------------------- Post Reply Name: Email (Opt.): Topic: Message: Link URL (Opt.): Link Title (Opt.): Image URL (Opt.): [ View Thread <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#followups> ] [ Post Reply <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589#postfp> ] [ Admin <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & admin=63589> ] [ Return to Main List <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent> ] [ Help <http://www.roadback.org/eboard30/help.htm> ] Lisbeth wrote: > Who's tried what successfully? > > Am I correct in thinking that treatment is contradictory for anyone > with diverticular disease and diverticulitus? > > Geoff?????? > > Why is nothing ever straight forward !! :-)) > > Huggles, > Lisbeth > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 15, 2006 Report Share Posted August 15, 2006 Hi Jeff; You are just too funny.Finally after almost 6 years of reading Rheumatic and Roadback postings I am getting to understand English wit but I know I cannot spell worth 2 cents..I finally found a great holistic/AP doctor a couple of years ago.She immediately had me tested for celiac after seeing an itchy little spot on my back that had been there since 1991.It was dermatitis herpetiformis and that is caused bu celiac.She had 2 tests done,one here and one in the U.S by Enterolab,she says it is the best.My count came in at 97 and should have been under 10.Until then I never heard the word Celiac.Dr. A says that over 80% of people with chronic diseases have it.She then had me tested for yeast and food sensetivities as she said that after all this time with celiac it would have done a lot of damage to the intestine and sure enough.Yeast was sky high,I have severe sensitivities to anything " cow " ,lamb,anything from the sugar cane,grapes,citrus,asperigus,beans and a couple others that are not so bad.Throughout all of this I never had any symptoms or knowlege that anything was wrong. Celiac hits 1in 133 normal people without them knowing and just about all sick people.There is a lot of info at www.celiac.com and how it causes chronic disease.AP had never worked well enough.After dropping all the no-no foods for 15 months I am just about normal and am on minimal antibiotics. F.Y.I we had my grandaughter's christening,I indulged in a slice ofFrench Bread with cheese,a couple of sweets and have felt so bad for the last 2 days,bloating,gas,pain and would you not know it....stiffening in my handsGuess I will behave until temptation gets me again P.S My sister has Lupus and her celiac count was even higher Lynne G Jeffery scott wrote: > Lynne, you're connecting your SD to Celiac? Leaky gut? > > I'm keeping an open mind about the cause(s) of SD, at least until > somebody > publishes THE definitive study in a major journal or Geraldo discovers > the > truth.....live. > The problem with Wootten is the same as with many > others.....acceptance of > their hypothesis is directly related to the commercial (and timely) > success > of their revolutionary products. Maybe the guy is the Einstein of the > intestinal world, but for me, he's got just a little bit of a credibility > bump in the road as long as he profits. Relatively speaking, Albert > received > only $28K for his Nobel theory and his ex took all of that and more. > Jeff > > ----Original Message Follows---- > From: lynneandsantos <lynneandsantos@... > <mailto:lynneandsantos%40citenet.net>> > Reply-rheumatic <mailto:rheumatic%40> > rheumatic <mailto:rheumatic%40> > Subject: Re: rheumatic Leaky gut > Date: Mon, 14 Aug 2006 10:18:22 -0400 > > Hi Lizbeth; > I have Celiac disease besides the SD and it most likely caused the > Leaky Gut and possibly the SD.He is a wee bit of info that may clarify > things. Lynne G. > > http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=Cu\ rrent & message=63589 > <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589> > <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589 > <http://www.roadback.org/cgi-bin/eboard30/index2.cgi?frames=no & board=Main & mode=C\ urrent & message=63589>> > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 29, 2006 Report Share Posted September 29, 2006 Hi Lea,if you go to www.roadback.org and to their bulletin board you can ask A Friend.This person had the problem and has an amazing amount of knowlege. Lynne G. SD leatannerone wrote: > If I'm taking a great probiotic and not eating sugar or drinking > alcohol, eating lots of veggies, does anyone know how long it will take > to repair leaky gut...it I do indeed have leaky gut? Lea > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 3, 2006 Report Share Posted October 3, 2006 Hi- I too went through a wickedly stressful period this past winter/spring, which brought on all the symptoms of leaky gut. I did the diet (still doing a modified version, although I can eat more normally now), increased the probiotics, but also went on Nystatin, which works to get rid of the yeast buggers in the gut which drill the holes to make the leaks. I have been on since may and the improvement has been remarkable. While I am all about using alternative methods, I think the Nystatin has been what has helped to heal my gut most. It does not have the side effects of other antifungals as it is not absorbed from the gut, but stays there to do the work. Good luck with everything...peggy > > Hi all, > > I'm basically a lurker - can't remember if I've written before this but I so appreciate > everyone's input and the positive attitudes in this group. I was in remission with R/A until > six months ago (I think high levels of stress brought it back). Now I'm on Plaquenil, > Celebrex and prednisone (1 mg) I refused methotrexate) but am working towards getting > on to the antibiotics and eventually off the drugs as much as possible. I now feel as > though I'm through the shock and grief period and into positive thinking again though it's > often very difficult to stay vigilant about my thoughts. > > A couple of weeks ago someone asked about Leaky Gut. Three months ago I was > diagnosed with it and the main thing for me is to stay off gluten and take acidophilus/ > probiotics and L-glutamine. I also watch my diet pretty strictly (no dairy or meat, sugar or > salt, nightshades or oranges) and I'm feeling so much better in myself (apart from the R/A) > that I can hardly believe it! My energy levels are much higher and I don't get " flat " or > discouraged or exhausted nearly as much. > > I know lots of people on this list do the non-processed food and alternative approach and > I know it doesn't do miracles re pain. I'm just saying what has helped me in my general > health. > > Many blessings and thanks to everyone from me in Australia. > > lind > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2009 Report Share Posted September 2, 2009 The following was posted on another list I'm on. Does anyone know about this? Alessio Fasano is a well-known and well-respected researcher with 170 publications and 150 patents. His main work is in the leaky gut and the role of leaky tight junctions in auto-immune diseases, especially Celiac. He recently published a very interesting article in Scientific American on this topic. There is no mention of autism in this article of course, but I found it VERY relevant to autism. Especially the mention of his new drug, Larazotide, that allows to close the tight junctions in the gut and the brain. Imagine that, a drug that would repair the blood/gut and blood/brain barrier... Celiac Disease Insights: Clues to Solving Autoimmunity Study of a potentially fatal food-triggered disease has uncovered a process that may contribute to many autoimmune disorders http://www.scientificamerican.com/article.cfm?id=celiac-disease-insights Larazotide is in clinical trials for celiac now, but I would give a lot to see what such a drug could do to an autistic patient: imagine no more food peptides leaking in the blood, no more gut flora byproducts leaking in the blood, no more toxins penetrating the blood/brain barrier: wouldn't that reduce inflamation (brain, gut, etc...), reduce the burden on the detox system, cool down the immune response? The interesting point is that not suprisingly, since mainstream still considers autism a brain hardware problem, I did not find any links between Alessio Fasano and autism on the web. Alessio Fasano, M.D. Gluten, Leaky Gut, and Autism: A Serendipitous Association or a Planned Design? http://www.defeatautismnow.com/dallas/speakers.html Here is a link to the company he started, Alba Therapeutics, to develop and market that drug Larazotide: http://www.albatherapeutics.com/Vision/TechnologyOverview/tabid/168/Default. aspx Kristy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2009 Report Share Posted September 2, 2009 Thank you. Very impressive information. JR From: knardini@... Date: Wed, 2 Sep 2009 20:51:06 -0700 Subject: Leaky gut The following was posted on another list I'm on. Does anyone know about this? Alessio Fasano is a well-known and well-respected researcher with 170 publications and 150 patents. His main work is in the leaky gut and the role of leaky tight junctions in auto-immune diseases, especially Celiac. He recently published a very interesting article in Scientific American on this topic. There is no mention of autism in this article of course, but I found it VERY relevant to autism. Especially the mention of his new drug, Larazotide, that allows to close the tight junctions in the gut and the brain. Imagine that, a drug that would repair the blood/gut and blood/brain barrier... Celiac Disease Insights: Clues to Solving Autoimmunity Study of a potentially fatal food-triggered disease has uncovered a process that may contribute to many autoimmune disorders http://www.scientificamerican.com/article.cfm?id=celiac-disease-insights Larazotide is in clinical trials for celiac now, but I would give a lot to see what such a drug could do to an autistic patient: imagine no more food peptides leaking in the blood, no more gut flora byproducts leaking in the blood, no more toxins penetrating the blood/brain barrier: wouldn't that reduce inflamation (brain, gut, etc...), reduce the burden on the detox system, cool down the immune response? The interesting point is that not suprisingly, since mainstream still considers autism a brain hardware problem, I did not find any links between Alessio Fasano and autism on the web. Alessio Fasano, M.D. Gluten, Leaky Gut, and Autism: A Serendipitous Association or a Planned Design? http://www.defeatautismnow.com/dallas/speakers.html Here is a link to the company he started, Alba Therapeutics, to develop and market that drug Larazotide: http://www.albatherapeutics.com/Vision/TechnologyOverview/tabid/168/Default. aspx Kristy Quote Link to comment Share on other sites More sharing options...
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