Re: Re: Percutaneous administration of progesterone

[Guest guest]

Hi Laurel,

Yes, it is good to be validated after saying something for years and being told it is not true!

What I find sad is that approx 4yrs ago (when I was on the WP), in one of our group meetings (where wiley would call in on the phone to answer questions), some of the group members were asking why their bld levels were so low (i had gotten the linea negra one gets during pregnancy and my serum P was approx 2.5). At that time.Wiley did say she suspected the low readings had to do with the RBCs and was talking with a lab on how to run the bld tests so it would be more accurate. However, that was the last anyone heard of it.....Apparently, though she was aware of these potentially inaccurate readings both she, and the drs selling her product, continued to push the dosage up to try and get the bld levels higher......sad!!!

Kam

This info ABSOLUTELY ROCKS!! If you were here in my town, I'd take you to the local farmers market and treat you to something fab and juicy! I'm thinking berries, not the young hunks. ;-p Thank you! Whoohoo! Dr. Formby said he suspected that the red blood cell issue was the problem and why were were showing wackadoodle ranges of ultra low levels of hormones while overdosed to the Moon! I've been saying that with astronomical hormone dosing you can't count on serem or saliva tests and now we have something to even say that with transdermal you can't count it. Laurel>> > > Thought this was interesting, so passing along!> Kam > --------------------- > When monitoring hormone levels while on transdermal replacement therpapy > serum testing is not accurate. This is because once absorbed through the skin > hormones bind to red blood cell membranes in the blood in order to > minimise unfavorable interactions with the aqueous water and the fat loving > hormones. Once your blood sample is taken it is centrifuged and the red blood > cells along with the hormones are removed prior to analysis. This phenomenon > was described by Z. Stanczyk (see references) for transdermal > progesterone but it also seems to occur to a lesser extent for all other > hormones. Serum tests show no increase in progestreone levels after weeks of > applying progesterone cream whereas saliva tests show an increase only after a > couple of hours! This is a significant problem monitoring levels if you are > using transdermal hormone creams. To illustrate this problem further > clinical trials performed by the American Academy of Anti-Aging on over 300 > patients revealed that every patient whose hormone levels were deemed at optimal > levels by serum blood tests had in actual fact excessive levels based on > saliva tests. The doses used to achieve optimal serum levels were higher than > standard physiological doses which was all that was required to achieve > optimal levels by saliva tests. In every case the patients doses were reduced > until saliva tests reflected optimal levels. In our own practice we see > this same phenomena on a regular basis with those patients being monitored by > serum blood tests â€" that is their current doses are too high! > The facts are there has never been a single study correlating serum values > for topically administered hormones to actual tissue levels or to long term > effectiveness. Most mainstream physicians have accepted serum testing as > the “gold standard†without any science which is based on some false > assumptions. You should never use serum testing for judging effectiveness or > hormone levels from topical application - Stanzyck’s article proves this for > progesterone and clinical observation sees it occuring with most other > hormones as well. > _http://www.custommedicine.com.au/hormone-analysis/_ > (http://www.custommedicine.com.au/hormone-analysis/) > ---------------- > Percutaneous administration of progesterone: blood levels and endometrial > protection> Stanczyk, Z. PhD; son, J. MD; Roy, Subir MD> > > > > > > > Abstract > > > > There is controversy about the beneficial effects of topical progesterone > creams used by postmenopausal women. A major concern is that serum > progesterone levels achieved with progesterone creams are too low to have a > secretory effect on the endometrium. However, antiproliferative effects on the > endometrium have been demonstrated with progesterone creams when circulating > levels of progesterone are low. Thus, effects of topical progesterone creams > on the endometrium should not be based on serum progesterone levels, but on > histologic examination of the endometrium. Despite the low serum > progesterone levels achieved with the creams, salivary progesterone levels are very > high, indicating that progesterone levels in serum do not necessarily > reflect those in tissues. The mechanism by which the serum progesterone levels > remain low is not known. However, one explanation is that after absorption > through the skin, the lipophilic ingredients of creams, including > progesterone, may have a preference for saturating the fatty layer below the dermis. > Because there appears to be rapid uptake and release of steroids by red > blood cells passing through capillaries, these cells may play an important > role in transporting progesterone to salivary glands and other tissues. In > contrast to progesterone creams, progesterone gels are water-soluble and > appear to enter the microcirculation rapidly, thus giving rise to elevated serum > progesterone levels with progesterone doses comparable to those used in > creams.> > _http://journals.lww.com/menopausejournal/Abstract/2005/12020/Percutaneous_a> dministration_of_progesterone__blood.19.aspx_ > (http://journals.lww.com/menopausejournal/Abstract/2005/12020/Percutaneous_administration_of_progesterone_> _blood.19.aspx) > > > > > > > > > > > Very extensive info here. You can see the list of reactions. Also talks > about things that increase clearance of P. I believe this site lifted > this from a site that requires a password and likely a subscription fee. I > couldn't find another version for free. > > > Check out the list of adverse effects. I got anaphylaxis response from > P. No allergies in my life until on P. I'd get a sudden sting near my lip > and suddenly half my face would be swollen. Never experienced such a thing > until exogenous P.> > Laurel> > _http://healthandprostate.com/index.php/drugs/progesterone_ > (http://healthandprostate.com/index.php/drugs/progesterone) > > > > (British Approved Name, rINN) > Drug Nomenclature> International Nonproprietary Names (INNs) in main languages (French, Latin, > Russian, and Spanish): > Synonyms: Corpus Luteum Hormone; Luteal Hormone; Luteine; Luteohormone; > NSC-9704;Pregnenedione; Progesteron; Progesterona; Progesteronas; > Progesteroni; Progesteronum; Progeszteron> BAN: Progesterone> INN: Progesterone [rINN (en)]> INN: Progesterona [rINN (es)]> INN: Progestérone [rINN (fr)]> INN: Progesteronum [rINN (la)]> INN: ßрþóõÑÂтõрþý [rINN (ru)]> Chemical name: Pregn-4-ene-3,20-dione> Molecular formula: C21H30O2 =314.5> CAS: 57-83-0> ATC code: G03DA04> Read code: y07kn; y07ko> Pharmacopoeias. In China, Europe, International, Japan, US. > European Pharmacopoeia, 6th ed. (Progesterone). Awhite or almost white > crystalline powder or colourless crystals. It exhibits polymorphism. > Practically insoluble in water freely soluble in dehydrated alcohol sparingly > soluble in acetone and in fatty oils. Protect from light. > The United States Pharmacopeia 31, 2008 (Progesterone). A white or > creamy-white, odourless, crystalline powder. Practically insoluble in water > soluble in alcohol, in acetone, and in dioxan sparingly soluble in vegetable > oils. Store in airtight containers at a temperature of 25°, excursions > permitted between 15° and 30°. Protect from light. > Adverse Effects> Progesterone and the progestogens may cause gastrointestinal disturbances, > changes in appetite or weight, fluid retention, oedema, acne, chloasma > (melasma), allergic skin rashes, urticaria, mental depression, breast changes > including discomfort or occasionally gynaecomastia, changes in libido, hair > loss, hirsutism, fatigue, drowsiness or insomnia, fever, headache, > premenstrual syndrome-like _symptoms_ > (http://healthandprostate.com/index.php/tag/symptoms) , and altered menstrual cycles or irregular menstrual bleeding. > Anaphylaxis or anaphylactoid reactions may occur rarely. Alterations in the > serum lipid profile may occur, and rarely alterations in liver-function > tests and jaundice. Pain, diarrhoea, and flatulence have followed rectal use. > Injection-site reactions have followed parenteral use. > Adverse effects vary depending on the dose and type of progestogen. For > example, androgenic effects such as acne and hirsutism are more likely to > occur with nor-testosterone derivatives such as norethisterone and norgestrel. > These derivatives may also be more likely to adversely affect serum lipids. > Conversely, adverse effects on serum lipids appear less likely with > gestodene and desogestrel, but these 2_drugs_ (http://healthandprostat> e.com/index.php/choosing-a-bph-drug) have been associated with a higher incidence of > thromboembolism than norethisterone and norgestrel when used in combined > oral contraceptives. High doses of progestogens such as those used in > treating _cancer_ > (http://healthandprostate.com/index.php/dictionary/prostate-cancer-2) have also been associated with thromboembolism. For a discussion of > the effect of progestogens on the cardiovascular risk profile of menopausal > HRT. Breakthrough uterine bleeding is more common with oral > progestogen-only contraceptives than when progestogens are used for menstrual > irregularities or as part of menopausal HRT. > Some progestogens when given during pregnancy have been reported to cause > virilisation of a female fetus. This appears to have been associated with > those progestogens with more pronounced androgenic activity such as > norethisterone the natural progestogenic hormone progesterone and its derivatives > such as dydrogesterone and medroxyprogesterone do not appear to have been > associated with such effects. For the adverse effects of progestogens when > administered either alone or with oestrogens as contraceptives. For those > ofmenopausal HRT. > Carcinogenicity. In a cohort study of women aged 40 to 64 years, the > premenopausal use of oral progestogens alone, mainly for benign breast, uterine, > and ovarian conditions, and irregular menstruation, was not associated > with an increased risk of breast _cancer_ > (http://healthandprostate.com/index.php/dictionary/prostate-cancer-2) . However, the data did suggest that there > was an increased risk for current users of progestogens for longer than > 4.5 years (relative risk 1.44, 95% confidence interval 1.03 to 2.00) compared > with women who had never used progestogens. Limitations of this study > included the lack of analysis of different progestogens or a record of the > reasons for progestogen_treatment_ > (http://healthandprostate.com/index.php/category/treatment) . > Effects on the skin. Auto-immune progesterone dermatitis includes > reactions such as eczema, urticaria, and angioedema that usually begin 3 to 10 days > before the onset of menstrual flow and end 1 to 2 days into menses, which > correlates with raised endogenous progesterone concentrations during the > luteal phase of the menstrual cycle. The onset of the condition can be as > early as menarche, and many women have never been exposed to exogenous > progesterone, but it has also occurred in women with a history of oral > contraceptive use. _Management_ > (http://healthandprostate.com/index.php/category/management) has been based on the suppression of endogenous progesterone > secretion and oral contraceptives are usually tried first, although they appear to > have limited success possibly because of the progestogen component. Other > _drugs_ (http://healthandprostate.com/index.php/choosing-a-bph-drug) that > have been used include corticosteroids, conjugated oestrogens, gonadorelin > analogues, androgens, and _tamoxifen_ > (http://healthandprostate.com/index.php/drugs/tamoxifen-citrate) , but all have significant adverse effects > associated with long-term use. Bilateral oophorectomy has been used in severe > cases, when drug _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) has been unsuccessful. > A woman with a history of auto-immune progesterone dermatitis developed > pruritic, pink, oedematous plaques and macules on the upper thighs, axillae, > and buttocks after the use of vaginal progestogen gel during infertility > _treatment_ (http://healthandprostate.com/index.php/category/treatment) . The > reaction was managed with topical corticosteroids. In another woman, with > a history of chronic urticaria exacerbated by progesterone, the use of > progesterone and various other progestogens as a component of HRT after > oophorectomy caused urticaria and angioedema.Desensitisation using micronised > progesterone was successful in this case. > Precautions> Progesterone and the progestogens should be used with caution in patients > with hypertension, cardiac or renal impairment, asthma, epilepsy, and > migraine, or other conditions which may be aggravated by fluid retention. > Progestogens can decrease glucose tolerance and diabetic patients should be > carefully monitored. They should also be used with care in persons with a > history of depression. High doses should be used with caution in patients > susceptible to thromboembolism. Progesterone and the progestogens should not be > given to patients with undiagnosed vaginal bleeding, nor to those with a > history or current high risk of arterial _disease_ > (http://healthandprostate.com/index.php/tag/disease) and should generally be avoided in hepatic > impairment, especially if severe. Unless progestogens are being used as part of > the _management_ (http://healthandprostate.com/index.php/category/management) > of breast or genital-tract carcinoma they should not be given to patients > with these conditions. > Although progestogens have been given as hormonal support during early > pregnancy such use is not now generally advised. However, the use of a > progesterone-type progestogen might still be considered for women who are > progesterone-deficient. Such use may prevent spontaneous evacuation of a dead > fetus, therefore careful monitoring of pregnancy is required. Progestogens > should not be used diagnostically for pregnancy testing and should not be given > in missed or incomplete abortion. > For precautions to be observed when progestogens are used as > contraceptives, see p.2065. For those to be observed when progestogens are used in > preparations for menopausal HRT. > Abuse. A case report of abuse of and dependency on progesterone. > Breast feeding. A large study compared a contraceptive > progesterone-releasing vaginal ring and a copper IUD for 1 year in breast-feeding women. There > was little difference in infant weight gain during the study, although at > 12 months the infants of mothers using the IUD were breast-fed less > frequently, receiving more supplementary feeding, and were heavier. There was no > adverse effect of progesterone on lactation or infant growth. Further > smaller studies have also found no adverse effect on lactation or infant growth. > The American Academy of Pediatrics has found no reports of adverse effects > in breast-fed infants of mothers given progesterone, and therefore > considers it to be usually compatible with breast feeding. > Porphyria. Progesterone and progestogens have been associated with acute > attacks of porphyria and are considered unsafe in patients with porphyria > (but medroxyprogesterone has been used with buserelin to suppress > premenstrual exacerbations of porphyria). Progestogens should generally be avoided by > all women with porphyria however, where non-hormonal contraception is > inappropriate, progestogens may be used with extreme caution if the potential > benefit outweighs the risk. The risk of an acute attack is greatest in women > who have had a previous attack or are under 30 years of age. Long-acting > progestogen preparations should never be used in those at risk. > Pregnancy. In Hungary, where 30% of all pregnant women were given hormonal > support _therapy_ (http://healthandprostate.com/index.php/tag/therapy) > with progestogens during the early 1980s, a case-control study suggested that > there was a causal relationship between such _treatment_ > (http://healthandprostate.com/index.php/category/treatment) and hypospadias in their > offspring. Mixed results have been reported in other studies of the association > between maternal progestogen use and the risk of hypospadias, but the > indications and types of progestogens used in early pregnancy have also changed > over time (for example, withdrawal bleeding induced by progestogens as a form > of pregnancy testing is no longer used, and progestogen luteal support in > early pregnancy is no longer recommended for routine use see also > Miscarriage, below). Nevertheless, results from a more recent case-control study of > deliveries between October 1997 and December 2000 suggested an increase in > risk of at least twofold. > There have also been reports of nongenital malformations, including limb > reduction defects, neural tube defects, and congenital heart malformations, > following intra-uterine exposure to progestogens in early pregnancy. > However, numerous analyses of accumulated data have found no evidence of a > recognisable malformation syndrome. > For details of individual case reports, see Pregnancy under Dydrogesterone, > Hydroxyprogesterone, Norethisterone, and Noretynodrel. For the effects of > hormonal contraceptive use during early pregnancy. For the risk of ectopic > pregnancy with progestogen-only contraceptives. > Veterinary use. An FAO/WHO expert committee examining the risks from > residue of veterinary _drugs_ > (http://healthandprostate.com/index.php/choosing-a-bph-drug) in foodstuffs established an acceptable daily intake for > progesterone, but concluded that there would be no need to specify a numerical > maximum residue limit for progesterone in the edible tissues of cattle when > products are used as growth promotors according to good practice. However, it > should be noted that in the EU the use of ster-oidal hormones such as > progestogens in veterinary practice is restricted, and their use as growth > promotors is banned. > Interactions> Enzyme-inducing _drugs_ > (http://healthandprostate.com/index.php/choosing-a-bph-drug) such as carbamazepine, griseofulvin, phenobarbital, phenytoin, > and rifampicin may enhance the clearance of progesterone and the > progestogens. These interactions are likely to reduce the efficacy of progestogen-only > contraceptives, and additional or alternative contraceptive measures are > recommended. > _Aminoglutethimide_ > (http://healthandprostate.com/index.php/drugs/aminoglutethimide) markedly reduces the plasma concentrations of > medroxyprogesterone acetate and_megestrol_ > (http://healthandprostate.com/index.php/drugs/megestrol-acetate) , possibly through a hepatic enzyme-inducing effect an > increase in progestogen dose is likely to be required. > Since progesterone and other progestogens can influence diabetic control an > adjustment in antidiabetic dosage could be required. Progestogens may > inhibit ciclosporin metabolism leading to increased plasma-ciclosporin > concentrations and a risk of toxicity. > Pharmacokinetics> Progesterone has a short elimination half-life and undergoes extensive > first-pass hepatic metabolism when given orally oral bioavailability is very > low although it may be increased somewhat by an oily vehicle and by > micronisation. Progesterone is absorbed when given buccally rectally or vaginally > and rapidly absorbed from the site of an oily intramuscular injection. > Various derivatives have been produced to extend the duration of action and to > improve oral activity. Esters of progesterone derivatives such as > hydroxyprogesterone caproate are used intramuscularly, and _megestrol acetate_ > (http://healthandprostate.com/index.php/drugs/megestrol-acetate) is orally > active. The ester medroxyprogesterone acetate is used orally and parenterally > 19-Nortestoster-one progestogens have good oral activity because the > 17-ethinyl substituent slows hepatic metabolism. Progesterone and the progestogens > are highly protein bound progesterone is bound to albumin and corticosteroid > binding globulin esters such as medroxyprogesterone acetate are > principally bound to albumin and 19-nortestosterone analogues are bound to > sex-steroid binding globulin and albumin. Progesterone is metabolised in the liver to > various metabolites including pregnanediol, which are excreted in the > urine as sulfate and glucuronide conjugates. Similarly, progestogens undergo > hepatic metabolism to various conjugates, which are excreted in the urine. > Progesterone is distributed into breast milk. > Uses and Administration> Progesterone is a natural hormone whereas progestogens are synthetic > compounds, derived from progesterone or 19-nortestosterone, with actions similar > to those of progesterone. Progestogens derived from 19-nortestosterone are > used as hormonal contraceptives, either alone or combined with an > oestrogen. The progesterone derivative medroxyprogesterone acetate is also used, > and progesterone itself has been used. Progestogens, and sometimes > progesterone, are used with oestrogens for menopausal HRT to reduce the increased > risk of endometrial hyperplasia and carcinoma that occurs when long-term > oestrogen _therapy_ (http://healthandprostate.com/index.php/tag/therapy) is > unopposed. > Similarly, _drugs_ > (http://healthandprostate.com/index.php/choosing-a-bph-drug) with progestogenic actions may be used in menstrual _disorders_ > (http://healthandprostate.com/index.php/category/disorders) such as > dysmenorrhoea and menorrhagia associated with dysfunctional uterine bleeding (below). > Progestogens may also be used in the _management_ > (http://healthandprostate.com/index.php/category/management) of endometriosis. Although progestogens > and progesterone have been used for the_management_ > (http://healthandprostate.com/index.php/category/management) of the premenstrual syndrome > (below), such a practice is of debatable value. > Progestogens may be valuable in advanced endometrial _cancer_ > (http://healthandprostate.com/index.php/dictionary/prostate-cancer-2) and have been > tried in some other malignancies. The progestogens typically used for > malignant _disease_ (http://healthandprostate.com/index.php/tag/disease) include > medroxyprogesterone acetate, _megestrol_ > (http://healthandprostate.com/index.php/drugs/megestrol-acetate) , and norethisterone. Some progestogens such > as _megestrol_ > (http://healthandprostate.com/index.php/drugs/megestrol-acetate) and medroxyprogesterone are used for the cachexia or wasting associated > with severe illness including _cancer_ > (http://healthandprostate.com/index.php/dictionary/prostate-cancer-2) and AIDS. > Progestogens have been widely advocated for either the prevention of > recurrent miscarriage or the_treatment_ > (http://healthandprostate.com/index.php/category/treatment) of threatened miscarriage (below). However, there is > little evidence of any benefit from such a practice and the use of > progestogens in early pregnancy is not now generally advised, with the exception of > the use of progesterone or a progesterone derivative in women who are > progesterone deficient (see also Precautions, above). Progesterone is, however, > the preferred drug for luteal support in women undergoing assisted > reproductive techniques such as IVF (see Infertility). > USES AND ADMINISTRATION OF PROGESTERONE. Progesterone is usually given as > an oily intramuscular injection, a vaginal gel or pessaries, or as > suppositories. Preparations containing micronised progesterone are also available > for oral and vaginal use. > In dysfunctional uterine bleeding or amenorrhoea 5 to 10 mg daily of > progesterone may be given by intramuscular injection for about 5 to 10 days > until 2 days before the anticipated onset of menstruation. Alternatively, > progesterone may be given for amenorrhoea as a vaginal gel at a usual dose of 45 > mg on alternate days for up to 6 doses the dose may be increased to 90 mg > in those who do not respond to the lower dose. An oral dose of 400 mg given > daily at bedtime for 10 days may also be used for amenorrhoea. > In women with a history of recurrent miscarriage and proven progesterone > deficiency, twice weekly intramuscular injection (increased to daily if > necessary) of 25 to 100 mg of progesterone, from about day 15 of the pregnancy > until 8 to 16 weeks, has been used. The dose may be increased to 200 mg > daily if necessary. Vaginal doses of micronised progesterone 200 to 400 mg > daily, in 2 divided doses, have also been given until week 12 of pregnancy. A > similar intramuscular schedule has been used for luteal support in IVF or > gamete intra-fallopian transfer techniques with _treatment_ > (http://healthandprostate.com/index.php/category/treatment) beginning on the day of > transfer of embryo or gametes. Alternatively, progesterone may be given vaginally > in assisted reproduction, but doses can vary widely depending on the > preparation. A vaginal gel may be given at a dose of 90 mg daily it is given for > 30 days if pregnancy occurs, and may be continued until there is placental > autonomy (up to 10 to 12 weeks). A dose of 90 mg twice daily has been used > in women with ovarian failure. A vaginal tablet containing micronised > progesterone 100 mg may be given 2 or 3 times daily _treatment_ > (http://healthandprostate.com/index.php/category/treatment) is started at oocyte retrieval > and continued for up to 10 weeks. Some soft capsules containing micronised > progesterone may also be suitable for intravaginal use in a dose of 400 to > 600 mg daily, in 2 or 3 divided doses, from the day of gonadotrophin > administration until week 12 of pregnancy. > Progesterone may be given vaginally or rectally in doses of 200 mg daily to > 400 mg twice daily for the_management_ > (http://healthandprostate.com/index.php/category/management) of the premenstrual syndrome. _Treatment_ > (http://healthandprostate.com/index.php/category/treatment) usually starts on > day 12 to 14 of the menstrual cycle and continues until the onset of > menstruation. Similar vaginal or rectal doses have also been used in the > _treatment_ (http://healthandprostate.com/index.php/category/treatment) of puerperal > (post-natal) depression. > Progesterone has been given as the progestogen component of menopausal HRT. > Soft capsules containing micronised progesterone are available in some > countries for oral use, given in a dose of 200 mg daily at bedtime for 12 to > 14 days of each month. Alternatively, a dose of 100 mg daily may be given > from day 1 to 25 of each cycle, resulting in less withdrawal bleeding. A > progesterone-releasing intra-uterine device has been used as a hormonal > contraceptive the device contains 38 mg of progesterone and is effective for up > to 12 months. A vaginal ring device that releases 10 mg of progesterone > daily is used in some countries for contraception in lactating women. The first > ring is inserted 6 weeks after delivery then replaced every 90 days. > Administration. A number of progesterone creams for topical application to > the skin are promoted in various countries for the _management_ > (http://healthandprostate.com/index.php/category/management) of menopausal > _symptoms_ (http://healthandprostate.com/index.php/tag/symptoms) and conditions > associated with progesterone deficiency. These are sometimes described as > containing ‘natural’ progesterone or phytoprogesterone from plant sources. > However, many of these products are available without prescription or medical > consultation and there has been some concern about their safety and > efficacy. Reviews have found early studies reporting that absorption of > progesterone from these creams was minimal. However, a later study using liquid > chromatography-tandem spectrometry of whole blood reported that steady-state > progesterone exposure was similar for women given either oral micronised > progesterone or topical cream. The authors suggested that the differences > between their results and previous studies were likely to have been caused by the > use of different analytical techniques, and that women using these creams > may in fact be exposed to higher systemic concentrations of progesterone > than previously thought. Some proponents of topical progesterone _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) have questioned the > importance of using serum concentrations as a marker for absorption. A review > concluded that available serum-progesterone concentrations probably remain > low after topical use and that further studies on the pharmacokinetics of > topical progesterone are needed. In terms of efficacy, a number of small > controlled studies have not shown progesterone cream to be any better than > placebo for the _management_ > (http://healthandprostate.com/index.php/category/management) of menopausal vasomotor _symptoms_ > (http://healthandprostate.com/index.php/tag/symptoms) or the prevention of bone loss, and mixed > results have been reported regarding the prevention of endometrial proliferation > associated with oestrogen _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) . > Menorrhagia. Menorrhagia, or excessive menstrual bleeding, is usually > defined as a blood loss exceeding 80 mL per menstrual period, compared with a > normal loss of about 30 mL. However, many women consider losses below 80 mL > to be excessive particularly if ‘flooding’ occurs. Although not > life-threatening, menorrhagia can lead to iron deficiency anaemia and considerably > impair quality of life. Menorrhagia may be associated with pelvic _disorders_ > (http://healthandprostate.com/index.php/category/disorders) such as > fibroids or endometriosis, the use of copper IUDs, or some systemic _disorders_ > (http://healthandprostate.com/index.php/category/disorders) . However, most > commonly it is associated with dysfunctional uterine bleeding a term used > to denote frequent, prolonged or heavy uterine bleeding for which no > specific cause is found (essential, idiopathic, or primary menorrhagia). Both > ovulatory (regular) and anovulatory cycles may give rise to dysfunctional > uterine bleeding. In general, medical _treatment_ > (http://healthandprostate.com/index.php/category/treatment) is used initially in women with no underlying > uterine abnormalities. The most commonly used _drugs_ > (http://healthandprostate.com/index.php/choosing-a-bph-drug) are NSATDs, tranexamic acid, > combined oral contraceptives, and progestogens, and choice of _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) may be influenced by the > contraceptive needs of the patient. Surgery can be used if medical > _management_ (http://healthandprostate.com/index.php/category/management) is > ineffective, and may be considered for first-line _treatment_ > (http://healthandprostate.com/index.php/category/treatment) in selected patients. > NSAIDs such as mefenamic acid, ibuprofen, and naproxen have been widely > used. They reduce menstrual blood loss by about 20 to 50%, and there does not > seem to be evidence to suggest that one NSAID is more effective than > another.l They are taken only during the menstrual phase, which reduces adverse > effects, and probably improves patient compliance they also have the > benefit of relieving dysmenorrhoea. Systematic review suggests that NSATDs are > less effective than tranexamic acid, danazol, and intra-uterine > levonorgestrel in reducing bleeding. NSAIDs are considered a suitable option when > hormonal_therapy_ (http://healthandprostate.com/index.php/tag/therapy) is not > acceptable. They should be stopped if _symptoms_ > (http://healthandprostate.com/index.php/tag/symptoms) do not improve within three menstrual cycles, but > can be used for as long as the patient finds them to be beneficial. > Given during menstruation tranexamic acid reduces menstrual blood loss by > about half the benefits of tranexamic _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) have been confirmed by systematic review. Like > NSATDs, tranexamic acid is considered a suitable option when hormonal > _therapy_ (http://healthandprostate.com/index.php/tag/therapy) is not acceptable. > It should be stopped if _symptoms_ > (http://healthandprostate.com/index.php/tag/symptoms) do not improve within three menstrual cycles, but can be used > for as long as the patient finds it to be beneficial. Etamsylate has been > used for menorrhagia, but it is less effective than NSAIDs and tranexamic > acid, and is no longer recommended. In women who require contraception, a > combined oral contraceptiveappears to be effective, although good evidence > of this is actually lacking. It has been suggested that extended-cycle > regimens should be considered for women with menorrhagia, as there are fewer > bleeding episodes per year of _treatment_ > (http://healthandprostate.com/index.php/category/treatment) . Traditional _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) with progestogens such as norethisterone or > medroxyprogesterone given during the luteal phase appears to be ineffective in > women with normal ovulatory cycles, although cyclical _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) may be of benefit in anovulatory > patients as it imposes a cycle. Progestogen _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) for 21 days of the cycle results in a > significant reduction in menstrual blood loss, but is associated with adverse > effects that may limit its acceptability. Long-acting injectable > progestogens, such as medroxyprogesterone acetate, reduce menstrual blood loss or > induce amenorrhoea when they are used as contraceptives. They have therefore > been used for menorrhagia, although specific studies for this indication are > lacking. > More recently, a contraceptive levonorgestrel-containing IUD has been > shown to be very effective in reducing menstrual blood loss in menorrhagia. UK > guidelines suggest that it should be considered first when either hormonal > or non-hormonal _treatment_ > (http://healthandprostate.com/index.php/category/treatment) is acceptable and long-term use is anticipated, although > comparative data are scanty. There is also some evidence that it may be an > effective alternative to surgery, but data from long-term follow-up are needed. > As there can be changes in bleeding pattern associated with this device, > particularly in the first few cycles, use for at least 6 months is advised > to enable full assessment of benefit. > Danazol is also effective, producing about a 50% reduction in menstrual > blood loss, but has significant adverse effects and _treatment_ > (http://healthandprostate.com/index.php/category/treatment) is usually limited to 3 to 6 > months. Gonadorelin analogues are effective for menorrhagia associated > with fibroids. When used pre-operatively for endometrial thinning, they > produce more consistent results than danazol. Gonadorelin analogues may therefore > be considered before surgery or when other options for fibroids are > contra-indicated, but ‘add-back’ hormone replacement is recommended for the > _management_ (http://healthandprostate.com/index.php/category/management) of > adverse effects from oestrogen deficiency or if they are used for more than 6 > months. > In patients who fail to respond to drug _treatment_ > (http://healthandprostate.com/index.php/category/treatment) , or in whom such _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) is inappropriate, various > surgical options exist. Conservative surgical techniques, where the endometrium > is ablated or resected, are increasingly being used, and are an effective > alternative to hysterectomy. Hysterectomy is the ultimate_therapy_ > (http://healthandprostate.com/index.php/tag/therapy) , but is associated with > significant morbidity. > Miscarriage. Threatened miscarriage is a common complication of pregnancy > that presents before 20 weeks of gestation as vaginal bleeding, with or > without abdominal pain, while the cervix is closed and the fetus is viable. > Endogenous progesterone is normally produced by the corpus luteum to maintain > pregnancy, and low concentrations have been associated with pregnancy > loss. Progestogen _therapy_ (http://healthandprostate.com/index.php/tag/therapy) > has therefore been widely used in the _treatment_ > (http://healthandprostate.com/index.php/category/treatment) of threatened miscarriage, but there > is a paucity of clinical study data to support routine use. Similarly, > progestogens have been used prophylactic ally to prevent miscarriage, but > studies have suffered from various limitations. A systematic review found no > evidence to support routine use, but there was limited evidence to suggest > that women with a history of recurrent miscarriage (3 or more consecutive > miscarriages) might gain some benefit. The BNF advises that progestogen > prophylaxis in women with a history of recurrent miscarriage is not recommended. > (See also Pregnancy, above, for reports of hypospadias in the offspring of > women given hormonal support _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) .) > Premature labour. Recommendations have been made regarding progesterone > _therapy_ (http://healthandprostate.com/index.php/tag/therapy) for the > prevention of premature birth in women at risk of preterm delivery (see under > Hydroxyprogesterone Caproate). > Premenstrual syndrome. Progestogen _therapy_ > (http://healthandprostate.com/index.php/tag/therapy) was once popular for premenstrual syndrome, but > beneficial responses have not been universally achieved and the theory that > progesterone was necessary to correct a hormone imbalance is now losing > ground. Progesterone has been given orally, vagi-nally, and rectally, in > continuous and luteal phase regimens. However, systematic reviews’ have found no > convincing evidence to support its use. > Preparations> British Pharmacopoeia 2008: Progesterone Injection > The United States Pharmacopeia 31, 2008: Progesterone Injectable > Suspension Progesterone Injection Progesterone Intrauterine Contraceptive System > Progesterone Vaginal Suppositories. > Proprietary Preparations> Argentina: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Faselut Gester Mafel Progest Proluton Utrogestan > Australia: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Proluton > Austria: Utrogestan > Belgium: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Progestogel Utrogestan > Brazil: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Evocanil Utrogestan > Canada: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Prometrium > Chile: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Hormoral Progendo Progering > Czech Republic: Agolutin _Crinone_ > (http://healthandprostate.com/index.php/tag/crinone) Utrogestan > Denmark: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Finland: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Lugesteron > France: Estima Evapause Progestogel Utrogestan > Germany: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Progestogel Utrogest > Greece: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Promenorea Utrogestan > Hong Kong: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cyclogest Endometrin Progestogel Utrogestan > Hungary: Utrogestan > India: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Dubagest Naturogest Profine Progest Remens Uterone > Indonesia: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Ireland: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Utrogestan > Israel: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Endometrin Gestone Utrogestan > Italy: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Esolut Lutogin Progeffik Progestogel Progestol †Prometrium Prontogest > Malaysia: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cyclogest Utrogestan †> Mexico: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cuerpo Amarillo Fuerte Gepromi Geslutin Gestageno Premastan Prosphere > Utrogestan > The Netherlands: Progestan > Norway: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > New Zealand: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Gestone > Philippines: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > > Poland: Luteina > Portugal: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Progenar †Progestogel Utrogestan > Russia: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Progestogel Utrogestan > South Africa: _Crinone_ > (http://healthandprostate.com/index.php/tag/crinone) Cyclogest Utrogestan > Singapore: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cyclogest Utrogestan > Spain: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Darstin Progeffik Progestogel †Progestosol Utrogestan > Sweden: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Switzerland: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Progestogel Utrogestan > Thailand: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cyclogest Gestone †Progestogel Utrogestan > Turkey: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cyclogest Progestan > UK: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Cyclogest Gestone Utrogestan > USA: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Endometrin Prochieve Progestasert †Prometrium > Venezuela: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) > Progendo Progestogel Utrogestan. > Multi-ingredient> Argentina: Cristerona Fempack Hosterona Lubriderm Menstrogen Tropivag Plus > Brazil: Ginecoside †Normomensil †> France: Florgynal Synergon Trophigil > Germany: Jephagynon †> Italy: Biormon †Menovis > Malaysia: Duogynon > Mexico: Damax Genofort Lutoginestryl †Metrigen Fuerte Ominol Primoson †> Progediol †Proger †> Portugal: Emmenovis †> Thailand: Duoton Phenoknon †> Turkey: Di-Pro Synergon > Venezuela: Cyclogesterin †Ginecosid.> _Buy non prescription drugs: Asacol, Diamox_ > (http://www.budgetdrugrx.com/generic-extra-drugs/) > > This post has been viewed 22401 times.> > Related posts: > 1. _Medrogestone_ > (http://healthandprostate.com/index.php/drugs/medrogestone) Buy non prescription drugs: Asacol, Diamox Drug Approvals (British > Approved Name, US Adopted Name, rINN) INNs in other languages (French, > Latin, and Spanish): Synonyms: AY-62022; Medrogeston; Medrogestona; > Medrogestoni; Medrogestonum; Metrogestone; NSC-123018; R-13-615 BAN: Medrogestone > USAN: Medrogestone INN: Medrogestone [rINN (en)] INN: Medrogestona [rINN > (es)]... > 2. _Megestrol Acetate_ > (http://healthandprostate.com/index.php/drugs/megestrol-acetate) Buy non prescription drugs: Asacol, Diamox Drug > Approvals (BANM, US Adopted Name, rINNM) Synonyms: BDH-1298; Compound 5071; > Megestrol, acetato de; Megestrol-acetát; Megestrolacetat; Megestroli Acetas; > Megestroliasetaatti; Megestrolio acetatas; Megesztrol-acetát; NSC-71423; > SC-10363 BAN: Megestrol Acetate [bANM] USAN: Megestrol Acetate INN: Megestrol > Acetate [rINNM (en)] INN: Acetato... > 3. _Tamoxifen Citrate_ > (http://healthandprostate.com/index.php/drugs/tamoxifen-citrate) Buy non prescription drugs: Asacol, Diamox (British > Approved Name Modified, US Adopted Name, rINNM) Drug Nomenclature INNs in main > languages (French, Latin, Russian, and Spanish): Synonyms: ICI-46474; > Tamoksifeenisitraatti; Tamoksifeno citratas; Tamoxifén-citrát; Tamoxifen citrát; > Tamoxifencitrat; Tamoxifeni Citras; Tamoxifeno, citrato de BAN: Tamoxifen > Citrate [bANM] USAN:... > 4. _Aminoglutethimide_ > (http://healthandprostate.com/index.php/drugs/aminoglutethimide) Buy non prescription drugs: Asacol, Diamox (British > Approved Name, rINN) Drug Nomenclature International Nonproprietary Names > (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: > Aminoglutethimid; Aminoglutethimidum; Aminoglutetimid; Aminoglutetimida; > Aminoglutetimidas; Aminoglutetimidi; Ba-16038 BAN: Aminoglutethimide INN: > Aminoglutethimide [rINN (en)] INN: Aminoglutetimida [rINN (es)] INN: > Aminoglutéthimide... > 5. _Doxazosin_ > (http://healthandprostate.com/index.php/drugs/doxazosin) Buy non prescription drugs: Asacol, Diamox Indications hypertension; > benign prostatic hyperplasia Cautions care with initial dose (postural > hypotension); cataract surgery (risk of intra-operative floppy iris syndrome); > susceptibility to heart failure; hepatic impairment; pregnancy; > breast-feeding; interactions: alpha-blockers Driving May affect performance of skilled > tasks e.g....> > Tags: _Crinone_ (http://healthandprostate.com/index.php/tag/crinone) , > _crinone-gel-systemic-absorption_ > (http://healthandprostate.com/index.php/tag/crinone-gel-systemic-absorption) , _crinone-no-prescription_ > (http://healthandprostate.com/index.php/tag/crinone-no-prescription) , _crinone-short-limb_ > (http://healthandprostate.com/index.php/tag/crinone-short-limb) , > _effective-alternative-to-prontogest-injections_ > (http://healthandprostate.com/index.php/tag/effective-alternative-to-prontogest-injections) , > _estramustin-and-thromboembolic_ > (http://healthandprostate.com/index.php/tag/estramustin-and-thromboembolic) , _gestone-compare-crinone_ > (http://healthandprostate.com/index.php/tag/gestone-compare-crinone) ,_headaches-from-tropivagplus-use_ > (http://healthandprostate.com/index.php/tag/headaches-from-tropivagplus-use) , > _intra-vaginal-use-of-hydroxy-progestrone-in-veterinary_ > (http://healthandprostate.com/index.php/tag/intra-vaginal-use-of-hydroxy-progestrone-in-veterinary) > , _is-utrogest-available-in-china_ > (http://healthandprostate.com/index.php/tag/is-utrogest-available-in-china) , > _luteina-progesterone-tablets-taken-orally-or-vaginally_ > (http://healthandprostate.com/index.php/tag/luteina-progesterone-tablets-taken-orally-or-vaginally) , _naturogest-vs-crinone_ > (http://healthandprostate.com/index.php/tag/naturogest-vs-crinone) > ,_progesterone-soft-gelatin-capsules-200mg-gestone-200mg_ > (http://healthandprostate.com/index.php/tag/progesterone-soft-gelatin-capsules-200mg-gestone-200mg) , > _progesterone-soft-gelatin-capsules-dubagest_ > (http://healthandprostate.com/index.php/tag/progesterone-soft-gelatin-capsules-dubagest) > ,_progestogel-for-thin-uterus_ > (http://healthandprostate.com/index.php/tag/progestogel-for-thin-uterus) , _progestogen-such-as-norethisterone_ > (http://healthandprostate.com/index.php/tag/progestogen-such-as-norethisterone) , > _promenorea-microionized-progesterone_ > (http://healthandprostate.com/index.php/tag/promenorea-microionized-progesterone) ,_utrogestan-in-norway_ > (http://healthandprostate.com/index.php/tag/utrogestan-in-norway) , > _vaginal-utrogestan-prevention-preterm-labor_ > (http://healthandprostate.com/index.php/tag/vaginal-utrogestan-prevention-preterm-labor) , _zoladex-for-autoimmune-progesterone-dermatitis_ > (http://healthandprostate.com/index.php/tag/zoladex-for-autoimmune-progesterone-dermat> itis) > Posted in: _Drugs_ (http://healthandprostate.com/index.php/category/drugs)>

[Guest guest]

Hi Nora,

This is good to know! I think I might have to make an appointment with him. I’m not interested in all kinds of supplements but I would love to try his hormones. I have E in Olive Oil but it’s drops. 1mg per drop. I’ve used it off/on for years but it doesn’t really work any better than the creams. Could be the concentration is not consistent as it needs to be shaken and I can see stuff at the bottom all the time. Do you know the name of the pharmacy that dispenses his gels? I would love to call them and ask more about them. You can email me privately if you want.

I too, appreciate everyone’s detailed postings.

Liz

Hi Liz,

I go to Uzzi Reiss. He uses lots of different things, depends on the person, he is very open. He favours certain methods over others however.

He gave me vaginal suppositories for P, which I use in small doses for 5 days a month. Works well for me. And I use E-2 in Olive Oil gel everyday (usually about 2 clicks or 2mg), twice a day. He prefers gel to patches as he believes you can control your own doses better. If you feel a symptom, you can use some gel, patches don’t take into account your natural hormone fluctuations. I find that once in the morning and early evening are the right times for me.

I always appreciate everyone’s detailed postings.

Nora

Reply-To: <rhythmicliving >

Date: Sun, 05 Jun 2011 07:47:12 -0700

To: <rhythmicliving >

Subject: Re: Re: Percutaneous administration of progesterone

Doesn’t Uzzi Reiss prescribe the gels instead of creams? I could be wrong. I’ve never tried P gels but the E gels go in so quickly and I have major reactions to them.

Has anyone tried P gel?

Liz

[Guest guest]

Hi Val,

Does she say anything about gel?

Nora

Reply-To: <rhythmicliving >

Date: Mon, 6 Jun 2011 09:15:06 -0600

To: <rhythmicliving >

Subject: RE: Re: Percutaneous administration of progesterone

Dr. G says the estradiol molecule is too large to be delivered through a cream base. I always wondered about Wiley and her creams.

Val

From: rhythmicliving [mailto:rhythmicliving ] On Behalf Of Liz Vernand

Hi Nora,

This is good to know! I think I might have to make an appointment with him. I’m not interested in all kinds of supplements but I would love to try his hormones. I have E in Olive Oil but it’s drops. 1mg pe r drop. I’ve used it off/on for years but it doesn’t really work any better than the creams. Could be the concentration is not consistent as it needs to be shaken and I can see stuff at the bottom all the time. Do you know the name of the pharmacy that dispenses his gels? I would love to call them and ask more about them. You can email me privately if you want.

I too, appreciate everyone’s detailed postings.

Liz

Hi Liz,

I go to Uzzi Reiss. He uses lots of different things, depends on the person, he is very open. He favours certain methods over others however.

He gave me vaginal suppositories for P, which I use in small doses for 5 days a month. Works well for me. An d I use E-2 in Olive Oil gel everyday (usually about 2 clicks or 2mg), twice a day. He prefers gel to patches as he believes you can control your own doses better. If you feel a symptom, you can use some gel, patches don’t take into account your natural hormone fluctuations. I find that once in the morning and early evening are the right times for me.

I always appreciate everyone’s detailed postings.

Nora

Reply-To: <rhythmicliving >

Date: Sun , 05 Jun 2011 07:47:12 -0700

To: <rhythmicliving >

Subject: Re: Re: Percutaneous administration of progesterone

Doesn’t Uzzi Reiss prescribe the gels instead of creams? I could be wrong. I’ve never tried P gels but the E gels go in so quickly and I have major reactions to them.

Has anyone tried P gel?

Liz

[Guest guest]

Hi,

I grew up in America, so I have experience of both .

Yes, I agree, dealing with doctors can be difficult and not one of my favourite things either. I do think the doctors in the UK listen a bit more, are less patronizing and expect patients to have some responsibility for their own health. It’s more an equal partnership. I always found that American doctors were not open to listening, knew all the answers and just wrote a prescription.

Health has always been important to me so I eat well (vegetarian with fish, lots of green drinks for alkaline balancing, etc.), work out and commit to optimizing my health. It’s an investment I put into myself.

But what I have found here on this Board, is not the normal attitude of the women I come across day to day. The women here do their own research and keep trying to find solutions in spite of tough circumstances or unsupportive doctors. It’s great and why I always read everyone’s posts carefully so that I can learn too. Most women I come across either believe their doctors verbatim, even if they feel poorly or don’t take the extra step to find out what to do next. I have one girlfriend here in the UK who has suffered for years with debilitating migraines and depression during PMS phase. I kept telling her about Dr. Moran here (the homeopathic guy), sent her Dr. Reiss’ book – National Superwoman and sent her links online. Our NHS here kept going down the ‘nothing is wrong with you’, offered her antidepressants, etc. and she suffered. Finally, she went to Dr. Moran (it cost her probably £300) and literally in two months her life was changed. She could have felt better 5 years ago.

Dr. Reiss works for me because he has my attitude about optimizing. We argue sometimes, because I am prepared when I go in and question what he says. He isn’t inside my body . And he does know a lot more than I do and has thousands of patients for experience! He also is very intuitive. He can look at you and almost do your hormone profile which I find brilliant.

Some new rules perhaps:

Don’t be intimidated

Be prepared

Don’t assume they have all the answers, doctors can be wrong

If you don’t feel right, it isn’t working, try something else

Do your own research

You may stumble a bit in the beginning as you try – standard doses don’t work for everyone on hormones There is some cost up front, but the costs decline when you find the system that works for you

Anything else?

Nora

Reply-To: <rhythmicliving >

Date: Mon, 6 Jun 2011 09:03:31 -0700

To: <rhythmicliving >

Subject: Re: Re: Percutaneous administration of progesterone

Nora,

Perhaps you get along with him because you conduct yourself in a certain manner and have a particular range of expectations that works for interacting with him? I wonder if the cultural difference of you being British helps?

Visiting a doctor can be very stressful for some and it can exacerbate negative feelings and insecuerities. I have had some really painful experiences with doctors so I can appreciate how some women have had trouble. I've tried to analyze what I need to do to have more power in the doctor's office and in most cases succeeded. Being prepared helps.

Do you have any thoughts on that?

Laurel

have been surprised when I've

Hi,

He is big on supplements, but he doesn’t force anything , I use a couple of them because it’s easy when I place an order for the hormones. He always is on top of the latest research too which I really like.

I like him because he always says ‘there is more that we can do’ and he always asks what would make me feel ‘amazing’. Great attitude. I’ve not had the kinds of problems I’ve read about on this Board, but even when I have small symptoms of PMS or some uncomfortable fluctuation, he believes it can be improved. And if one thing doesn’t work, there will be something else.

I don’t know what pharmacy he uses, but he must send them a great deal of business! He does things over the phone too, so it’s easy to call and find out. I’m in England after all! I get there once a year for blood tests. But I’ve adopted the philosophy that the numbers are only a benchmark, it is really about how I feel and not getting attached to a number which is what I did in the beginning.

I also appreciate that he is unique with the other good doctors we’ve mentioned on this Board. Here is England, there is one good homeopathic doctor I’ve found, who is more conservative than Dr. Reiss, but has helped a few of my friends hear who couldn’t get any traditional doctors to listen. With relatively simple hormone treatments, they were able to counter PMS depression, inconsistent periods and lumpy breasts. I respect our NHS system of care a lot, but they really miss on these types of things. Women’s health is still a black hole unfortunately. It’s why I appreciate this Board and at least having a place to exchange information.

Nora

Reply-To: <rhythmicliving >

Date: Mon, 06 Jun 2011 07:02:18 -0700

To: <rhythmicliving >

Subject: Re: Re: Percutaneous administration of progesterone

Hi Nora,

This is good to know! I think I might have to make an appointment with him. I’m not interested in all kinds of supplements but I would love to try his hormones. I have E in Olive Oil but it’s drops. 1mg per drop. I’ve used it off/on for years but it doesn’t really work any better than the creams. Could be the concentration is not consistent as it needs to be shaken and I can see stuff at the bottom all the time. Do you know the name of the pharmacy that dispenses his gels? I would love to call them and ask more about them. You can email me privately if you want.

I too, appreciate everyone’s detailed postings.

Liz

Hi Liz,

I go to Uzzi Reiss. He uses lots of different things, depends on the person, he is very open. He favours certain methods over others however.

He gave me vaginal suppositories for P, which I use in small doses for 5 days a month. Works well for me. And I use E-2 in Olive Oil gel everyday (usually about 2 clicks or 2mg), twice a day. He prefers gel to patches as he believes you can control your own doses better. If you feel a symptom, you can use some gel, patches don’t take into account your natural hormone fluctuations. I find that once in the morning and early evening are the right times for me.

I always appreciate everyone’s detailed postings.

Nora

Reply-To: <rhythmicliving >

Date: Sun, 05 Jun 2011 07:47:12 -0700

To: <rhythmicliving >

Subject: Re: Re: Percutaneous administration of progesterone

Doesn’t Uzzi Reiss prescribe the gels instead of creams? I could be wrong. I’ve never tried P gels but the E gels go in so quickly and I have major reactions to them.

Has anyone tried P gel?

Liz

[Guest guest]

That is all she recommends, Nora - Estrogel, applied to fat areas. Val From: rhythmicliving [mailto:rhythmicliving ] On Behalf Of Nora RothrockHi Val,Does she say anything about gel?NoraDr. G says the estradiol molecule is too large to be delivered through a cream base. I always wondered about Wiley and her creams. Val From: rhythmicliving [mailto:rhythmicliving ] On Behalf Of Liz VernandHi Nora,This is good to know! I think I might have to make an appointment with him. I’m not interested in all kinds of supplements but I would love to try his hormones. I have E in Olive Oil but it’s drops. 1mg pe r drop. I’ve used it off/on for years but it doesn’t really work any better than the creams. Could be the concentration is not consistent as it needs to be shaken and I can see stuff at the bottom all the time. Do you know the name of the pharmacy that dispenses his gels? I would love to call them and ask more about them. You can email me privately if you want.I too, appreciate everyone’s detailed postings.Liz