Progesterone creams...just passing along.

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The Key to Safely and Effectively Using Progesterone Cream

If you want to copy nature and reproduce a hormonal environment that most closely resembles a normal premenopausal woman the first logical step would be to get the hormones directly into your blood stream, just the way your ovary does.

Hormones carefully measured and formulated in an appropriate cream or gel need only be rubbed once or twice a day into your mucous (epithelial) membranes. Since there are no destructive detours through your GI tract when administered this way, your tissues are exposed to the appropriate concentrations of the hormone without the side effects of 30 different liver metabolites.

I first started using these creams in the early 1990s be became gradually disenchanted with them after I noticed that they typically worked wonderfully initially but then invariably stopped working. This is now known as "dermal fatigue".

What happens, not only for progesterone cream, but for ANY hormone preparation you use by applying as a cream to your skin is that within a few weeks to a few months you will saturate the fat tissue with the hormones and they will actually stop working or can even make your symptoms worse.

The problem relates to the fact that progesterone is highly fat soluble and once applied to your skin will store itself in your fat tissue. When one initially uses the cream, there aren't any problems as the fat stores are very low. But as time goes on, the cream accumulates and contributes to disruptions in your adrenal hormones such as DHEA, cortisol, and testosterone. I have learned that although progesterone cream is an enormously useful tool, it needs to be used very cautiously.

I found that many of the women who were on the cream have terribly elevated levels of this hormone. Progesterone is normally a cyclical hormone and the body really needs to see a change in the concentration to affect a proper physiological response. If the level is constantly above the concentration that it recognizes as "off" or low, this is not possible.

Fortunately, this is repairable. But it may involve going off the cream for as long as two years to wash the progesterone out of your system.

http://articles.mercola.com/sites/articles/archive/2011/09/18/oral-progesterone-and-progesterone-cream-complications.aspx?e_cid=20110918_SNL_Art_1