Notes on todays xmvr webcast - anyone know about peptide T?

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http://forums.aboutmecfs.org/showthread.php?2975-Free-Mikovits-web-talk-from

-Cheney-Clinic-Wednesday-Feb-10th%21-1-00-EST/page19 (public forum)

This is my quick summary of the interview today between Cheney and

Mikovits. Please feel free to add to or correct any errors.

Treatment idea for XMRV

Peptide T may be a useful treatment for XMRV. It interacts with the

monocyte in retroviral diseases. http://en.wikipedia.org/wiki/Peptide_T

What bout UK and German negative results and VIP negatives?

There is very low level of XMRV in blood. Researchers must use all

techniques. PCR is ineffective. Culture also if low level in blood. We don't

know where the reservoir of the virus is.

Gow et al in the UK found XMRV at 4,6 in healthy population yet found

none in cfs patients. Mikovits said they used a different reagent and did

not ask WPI what reagent to use.

What to do if you tested negative at VIP or want to be tested?

Go to the WPI website and sign up to be in their study. They are

notifying all who have signed up about upcoming studies. They hope to have

all of these patients notified in the next week.

Does XMRV enter the brain, and what specific area?

It probably enters microglia cells which take it to the brain. It

certainly could affect the autonomic nervous system. We do not know what

particular area of the brain is affected.

How XMRV transmitted?

Certainly use HIV universal precautions - sexual protection, never share

razors or toothbrushes. Perhaps be careful about sharing glasses, exchange

of saliva. We don't know.

Many cfs patients have elevated RNaseL. Would this suggest XMRV?

Yes, elevated NNaseL is a sign of an active viral infection.

NK cell function would be elevated and/or defective. NK cells clear

viruses and tumor cells.

CD4 to CD8 ratio is abnormal?

Mikovits said, " We are not seeing this. "

Would there be activation of herpes viruses - EBV, CMV, HHV6?

Yes, because XMRV and HIV cause immune deficiency. WE WOULD ALSO SEE

THIS EFFECT IN CHRONIC LYME CASES.

Would XMRV cause neurological problems - disturbance of the vestibular

system?

Yes, there would be myopathy, can't walk. This would be coming from the

neurotoxicity of the XMRV infection. (I am not sure I got all of this)

Immune system changes would involved elevated cytokines and TGF beta.

Were the CFS outbreak clusters driven by a retrovirus?

We certainly think so and are investigating this.

Cheney discussed briefly the expectation of recovery saying that age was

the key factor. People over 40 were least likely to recover.and if the

patient had been sick for longer than 5 years. Severity of the illness was

not an issue. You could be very sick and still recover. Degree of stress

makes it much worse because of the cortisol response. Mikovits concurred on

this. Cortisol feeds the virus. [Not sure that is the way she put it, but

you get the point.]

A male patient, monolike onset at age 25, years later developed

testicular cancer and a heart rhythm disturbance. Could these all be related

to XMRV.?

Yes.

Cheney mentioned last that heart symptoms are from right ventricular

strain and diastolic dysfunction found in 97% of cfs cases. You know you

have this when you cannot mall shop and heat and standing cause energy

problems. [i would describe that as feeling like you are about to pass out

on the ground.] This is coming from energy problems at a cellular level.

Again, Mikovits suggested that XMRV could cause this.

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