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Re: xeno clarification

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Hi E,

You misunderstood what I said about xeno-estrogens, or I didn't say it clearly enough. The xenos take up the receptors. I thought I made that clear.

Cholesterol is not a problem. There is a relationship between longevity and HIGH cholesterol levels, and I can quote all day about that, but I doubt we will change each other's mind about it.

I don't have the time or energy to get into the other areas where I disagree with you, certainly not on the P issue.

I do wonder why your MD tortured you with the synthetic P, and why you think that lack of a uterus equals castration.

Thank you for your kind note. I just disagree with a great deal of it. But that's what makes horse races! :)

Gael

Gael:You are very clear and you are very kind in sharing. But please do not take this the wrong way because I have to correct your interpretation. Please understand that some of your interpretation is correct but not all. It is really confusing in the words that doctors and researchers use. Truth is when people use the words "estrogen disruptors" it seems like something will get into the site and "block" as you say estrogen from getting into the site, but please understand that is not necessarily the case. In fact most of the time it is not the case at all. The xenoestrogen mimic estrogen and other hormones, which means that they go into the receptor for estrogen, (that is not suppose to happen) "trick" the receptor into letting it in but since it is not estrogen it can effect more than one hormone, effect the pathways in which estrogen is utilized and can cause a whole host of problems that are difficult to predict. If you remember from HS Biol ogy class one receptor for one enzyme, well the body is only suppose to accept estrogen, but "drugs" and other chemicals are disrupting the normal estrogen pathway. Maybe even changing the way estrogen is utilized even when it is true estrogen that binds to the receptors. So no, they do not really block estrogen from getting in there are millions of receptors on every cell in your body (that just floors me right there, the human body is amazing!) estrogen gets in too, and there ya go, the body can perceive too much estrogen. Actually that is just one of the things that the body can perceive, there are many more, and some we don't even know about, realize the research is so new. So if you give estradiol, more estrogen, wow, now you have what the body makes, the xeno estrogens, the phytoestrogens, (which is why some people should not eat soy) and you have more estradiol! But don't believe me, I looked up the research for you.Front Biosci. 2003 Jan 1;8:s110-8.Xenoestrogen exposure and mechanisms of endocrine disruption.Singleton DW, Khan SA.SourceDepartment of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA.AbstractEnvironmental xenoestrogens can be divided into natural compounds (e.g. from plants or fungi), and synthetically derived agents including certain drugs, pesticides and industrial by-products. Dietary exposure comes mainly from plant-derived phytoestrogens, which are thought to have a number of beneficial actions. However, high levels of exogenous estrogens including several well-known synthetic agents are associated with harmful effects. Chemicals like xenoestrogens, which can mimic endogenous hormones or interfere with endocrine processes, are collectively called endocrine disruptors. Adverse effects by endocrine disrupting chemicals (particularly xenoestrogens) include a number of developmental anomalies in wildlife and humans. Critical periods of urogenital tract and nervous system development in-utero and during early post-natal life are especially sensitive to hormonal disruption. Furthermore, damage during this vulnerable time is generally permanent, whereas in adulthoo d, ill effects may sometimes be alleviated if the causative agent is removed. The most commonly studied mechanism in which xenoestrogens exert their effects is through binding and activation of estrogen receptors a and similar to endogenous hormone. However, endocrine disruptors can often affect more than one hormone (sometimes in opposite directions), or different components of the same endocrine pathway, therefore making it difficult to predict effects on human health. In addition, xenoestrogens have the potential to exert tissue specific and nongenomic actions, which are sensitive to relatively low estrogen concentrations. The true risk to humans is a controversial issue; to date, little evidence exists for clear-cut relationships between xenoestrogen exposure and major human health concerns. However, because of the complexity of their mechanism and potential for adverse effects, much interest remains in learning how xenoestrogens affect normal estrogen signaling.PMID: 12456297 [PubMed - indexed for MEDLINE]Oh and I have to correct you again, if you deaminate protein, meaning that you take off the nitrogen from a protein molecule, yes it does turn to glucose (sugar), and the body will use too much protein as energy which is why the Atkins diet doesn't really work, but I digress.At 55 years old I know that you did not go all the way through menopause yet, but your hormones have been declining for many years before that. I have to admit, although I don't want to wish my life away, I would rather be dealing with this at 55 not 45. At 55, bleeding is just not a good sign. I am so sorry you had to go through that. I am not so sure I agree about progesterone causing your bought with atypia, the cells of the uterus do not respond to progesterone like that. In fact high doses of progesterone down regulates estrogen production. There are some studies that have shown that certain estrogens down regulate proteins that are found in breast cancer but again we have to be careful interpreting those studies because those receptors are not the same as the ones in the uterus. The study I read was a metabolite called 1,7, Betaestradiol. Is that the drug that they give when the give estradiol. Hmmmm? The woman was correct, you had a 40 percent chance of it changing to cancer, which I also thought was not a bad chance either, however in cancer circles that is way too high!I was not insinuating that your ovaries are killed after hysterectomy but when you remove the broad ligament, and other structures with the uterus, many of the blood vessels to the ovaries are cut, many nerves to the ovaries are cut, heck, even nerves to the urinary bladder are cut, to the skin... well you get the picture. Every person is different, different nerve supply and different blood supply. You had every right to worry, every person that has this done has different and the same side effects. You are very lucky that your ovaries still produce hormones, some women's hormones stop immediately, some stop within two years. No your ovaries do not shrivel up and die, but the uterus also makes hormones when it is not there the ovaries stop producing the hormones in the same amounts and sometimes not at all. The studies that show that keeping ovaries are not that conclusive, but it is great that they are doing these studies, they are also showing that the right combo of hormones post surgery will prevent the heart disease, osteoporosis and dementia related to oophorectomy. Which is probably why you are using the Vivelle dot and are very happy with it.Gael, thanks so much for sharing but please understand that in the US, there is no reason to eat meat, in fact cholesterol only comes from animal products. We over eat protein in the US, I am not going to get into it at all, but we can get more than enough nutrition by eating plant products and not have to kill an animal to do it. I did not have problems with infertility because I am a vegan, if anything I had problems with infertility because of a lot of stress in my life and because I was too old. The genetic material in my ova made the eggs not viable, or it could of been the sperm of my partner, or it could of been my uterus, where there is a problem to begin with which is what I think but the doctors said no. E

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