Imperial Urine study again.. NOT about early detection

[Guest guest]

>

> just reading the abstract, the newspaper article was off the mark (no kidding

> - the study was not about early detection, and results do NOT indicate

> that these markers were present from an early age....

>

> but they are def there now!

>

> Novel findings associated with alterations in nicotinic acid metabolism within

> autistic individuals showing increased urinary excretion of

> N-methyl-2-pyridone-5-carboxamide, N-methyl nicotinic acid, and N-methyl

> nicotinamide indicate a perturbation in the tryptophan?nicotinic acid

> metabolic pathway. Multivariate statistical analysis indicated urinary

> patterns of the free amino acids, glutamate and taurine were significantly

> different between groups with the autistic children showing higher levels of

> urinary taurine and a lower level of urinary glutamate, indicating

> perturbation in sulfur and amino acid metabolism in these children.

> Additionally, metabolic phenotype (metabotype) differences were observed

> between autistic and control children, which were associated with

> perturbations in the relative patterns of urinary mammalian-microbial

> cometabolites including dimethylamine, hippurate, and phenyacetylglutamine.

> These biochemical changes are consistent with some of the known abnormalities

> of gut microbiota found in autistic individuals and the associated

> gastrointestinal dysfunction and may be of value in monitoring the success of

> therapeutic interventions.

>

>

> http://pubs.acs.org/doi/full/10.1021/pr901188e?prevSearch=autism & searchHistory

> Key=

>

>

> btw tryptophan?nicotinic acid metabolic pathway is linked to IDO/interferron

> pathway, ie infection/inflammation!

>

>

>

>

> Neno/Natasa <neno@...> wrote:

>> >

>> >

>> > But wait a minute, isn't it all in the head ;-)

>> >

>> >

>> >

>> http://www.telegraph.co.uk/health/healthnews/7801077/Autism-test-could-make-

>> > the-condition-preventable.html

>> >

>> >

>> >

>> > .... Professor Nicholson, the author of the study, said: " Children

>> > with autism have very unusual gut microbes which we can test for before the

>> > full blown symptoms of the disease come through.

>> >

>> > " If that is the case then it might become a preventable disease. " ....

>> >

>> >

>> >

>> > Imperial College news release:

>> >

>> >

>> http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/ne

>> > ws_3-6-2010-11-17-32?newsid=90301

>> >

>

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