Guest guest Posted November 8, 2010 Report Share Posted November 8, 2010 lol that's almost funny. 18 out of 15,700somthing, and only 6 of them had autism when 1 in 90 have autism... But 82% in a small study posted in poster board at the 1st International XMRV Converence positive for XMRV - very close to the number of CFS positive. ________________________________ From: Bill klimas <klimas_bill@...> Sent: Mon, November 8, 2010 9:09:38 AM Subject: Genome Article  Guys Here is yet anther totally insignificant finding on chromosomal Damage. It reads like a break through until you do the math. They found a deletion in 18 out of 15000 kids on the spectrum and them published it as a major break though, Amazing! Crappy science without merit! They could have as easily looked for XMRV presence in 15,000 kids. Lets get he resources away from the genetics guys and send it to some viralologists. What a waste of money. Chromosome Change Points to Autism, SchizophreniaLiveScience.com " height= " 27 " width= " 73 " > * Buzz up!0 votes * Chan MyHealthNewsDaily Staff Writer LiveScience.com Chan myhealthnewsdaily Staff Writer livescience.com – 16 mins ago People who possess a specific change in one of their chromosomes are nearly 14 times more likely to develop an autism spectrum disorder or schizophrenia than those without this change, according to a new study. The change, which is called a deletion, happens when a section of chromosome 17 is missing. The deletion is found only in people who have an autism spectrum disorder, a developmental delay or schizophrenia, said study researcher H. Ledbetter, a genetics professor at Emory University. " This is just adding one more to that rapidly growing list of genetic mutations " associated with autism that doctors could use to measure autism and schizophrenia risk in children, Ledbetter told MyHealthNewsDaily. Not all people with autism, a developmental delay or schizophrenia have this deletion. But all people who have the chromosome change will develop some form of the disorders, whether it's mild or strong enough for a diagnosis, he said. Schizophrenia and autism are separate disorders, but other recent research has also shown the two have genetic similarities. " At least in a subset of autism and a subset of schizophrenia, the same [genetic changes] play a major role in both, " Ledbetter said. " It will be interesting in the future, because we'll have the ability to identify this type of deletion in young children, and follow them to figure out why some of them do develop autism and some don't. " The new study was published today (Nov. 4) in the American Journal of Human Genetics. Detecting the deletion Researchers looked in a genetic database of 15,749 people with a developmental delay, intellectual disability or an autism spectrum disorder. They found 18 of these people had the deletion on chromosome 17. But not one of the 4,519 healthy people tested had the deletion, according to the study. Researchers tracked down nine of the 18 people in the database with the genetic deletion. All nine had cognitive impairments, and six of them had autism, the study said. To confirm these findings, researchers looked at two other databases that had genetic information for 7,522 people with autism or schizophrenia. They found the same deletion in two people with an autism spectrum disorder or cognitive impairment, and four adults with schizophrenia. None of the 43,076 healthy people tested had the deletion. " That means the deletion has a major phenotypic effect, " Ledbetter said. " It can manifest as developmental delay, intellectual disability or autism, or it may not be diagnosed and recognized until adulthood when there are psychiatric manifestations that lead to a diagnosis of schizophrenia. " In line with the research Some of the people with the deletion also had other health problems, such as renal cysts and diabetes. " We're starting to appreciate now that oftentimes, when we talk about psychiatric conditions, it doesn't really come just by itself, " said Andy Shih, vice president of science for the nonprofit Autism Speaks, who wasn't involved with the study. " A lot of times, you see a host of other conditions that travels with autism. " Previous work has found genes that are associated with autism, but these genes have " low penetrance " - meaning the genes were also found in people who don't have any symptoms of autism, said Rodier, a professor at the University of Rochester School of Medicine and Dentistry. " But in this case, it appears that virtually all of the people who have this anomaly of this gene have some symptoms, " said Rodier, who wasn't involved with the study. The new findings could be used in a genetic test that could help people confirm an autism or schizophrenia diagnosis, as well as determine their risk of developing one of these conditions, Rodier said. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 8, 2010 Report Share Posted November 8, 2010 82% of a pool of kids with autism tested positive for XMRV? Out of what number? Wow. That is VERY interesting. Sent from my iPhone On Nov 8, 2010, at 2:17 PM, <thecolemans4@...> wrote: lol that's almost funny. 18 out of 15,700somthing, and only 6 of them had autism when 1 in 90 have autism... But 82% in a small study posted in poster board at the 1st International XMRV Converence positive for XMRV - very close to the number of CFS positive. ________________________________ From: Bill klimas <klimas_bill@...> Sent: Mon, November 8, 2010 9:09:38 AM Subject: Genome Article Guys Here is yet anther totally insignificant finding on chromosomal Damage. It reads like a break through until you do the math. They found a deletion in 18 out of 15000 kids on the spectrum and them published it as a major break though, Amazing! Crappy science without merit! They could have as easily looked for XMRV presence in 15,000 kids. Lets get he resources away from the genetics guys and send it to some viralologists. What a waste of money. Chromosome Change Points to Autism, SchizophreniaLiveScience.com " height= " 27 " width= " 73 " > * Buzz up!0 votes * Chan MyHealthNewsDaily Staff Writer LiveScience.com Chan myhealthnewsdaily Staff Writer livescience.com – 16 mins ago People who possess a specific change in one of their chromosomes are nearly 14 times more likely to develop an autism spectrum disorder or schizophrenia than those without this change, according to a new study. The change, which is called a deletion, happens when a section of chromosome 17 is missing. The deletion is found only in people who have an autism spectrum disorder, a developmental delay or schizophrenia, said study researcher H. Ledbetter, a genetics professor at Emory University. " This is just adding one more to that rapidly growing list of genetic mutations " associated with autism that doctors could use to measure autism and schizophrenia risk in children, Ledbetter told MyHealthNewsDaily. Not all people with autism, a developmental delay or schizophrenia have this deletion. But all people who have the chromosome change will develop some form of the disorders, whether it's mild or strong enough for a diagnosis, he said. Schizophrenia and autism are separate disorders, but other recent research has also shown the two have genetic similarities. " At least in a subset of autism and a subset of schizophrenia, the same [genetic changes] play a major role in both, " Ledbetter said. " It will be interesting in the future, because we'll have the ability to identify this type of deletion in young children, and follow them to figure out why some of them do develop autism and some don't. " The new study was published today (Nov. 4) in the American Journal of Human Genetics. Detecting the deletion Researchers looked in a genetic database of 15,749 people with a developmental delay, intellectual disability or an autism spectrum disorder. They found 18 of these people had the deletion on chromosome 17. But not one of the 4,519 healthy people tested had the deletion, according to the study. Researchers tracked down nine of the 18 people in the database with the genetic deletion. All nine had cognitive impairments, and six of them had autism, the study said. To confirm these findings, researchers looked at two other databases that had genetic information for 7,522 people with autism or schizophrenia. They found the same deletion in two people with an autism spectrum disorder or cognitive impairment, and four adults with schizophrenia. None of the 43,076 healthy people tested had the deletion. " That means the deletion has a major phenotypic effect, " Ledbetter said. " It can manifest as developmental delay, intellectual disability or autism, or it may not be diagnosed and recognized until adulthood when there are psychiatric manifestations that lead to a diagnosis of schizophrenia. " In line with the research Some of the people with the deletion also had other health problems, such as renal cysts and diabetes. " We're starting to appreciate now that oftentimes, when we talk about psychiatric conditions, it doesn't really come just by itself, " said Andy Shih, vice president of science for the nonprofit Autism Speaks, who wasn't involved with the study. " A lot of times, you see a host of other conditions that travels with autism. " Previous work has found genes that are associated with autism, but these genes have " low penetrance " - meaning the genes were also found in people who don't have any symptoms of autism, said Rodier, a professor at the University of Rochester School of Medicine and Dentistry. " But in this case, it appears that virtually all of the people who have this anomaly of this gene have some symptoms, " said Rodier, who wasn't involved with the study. The new findings could be used in a genetic test that could help people confirm an autism or schizophrenia diagnosis, as well as determine their risk of developing one of these conditions, Rodier said. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 8, 2010 Report Share Posted November 8, 2010 I know. I know. It is extremely frustrating. I do hope the research will go into another direction (yes, I do have the hope gene - which is why I get burned so often).  Cheers,  Jill From: Bill klimas <klimas_bill@...> Subject: Genome Article Date: Monday, November 8, 2010, 10:09 AM  Guys Here is yet anther totally insignificant finding on chromosomal Damage. It reads like a break through until you do the math. They found a deletion in 18 out of 15000 kids on the spectrum and them published it as a major break though, Amazing! Crappy science without merit! They could have as easily looked for XMRV presence in 15,000 kids. Lets get he resources away from the genetics guys and send it to some viralologists. What a waste of money. Chromosome Change Points to Autism, SchizophreniaLiveScience.com " height= " 27 " width= " 73 " > * Buzz up!0 votes * Chan MyHealthNewsDaily Staff Writer LiveScience.com Chan myhealthnewsdaily Staff Writer livescience.com – 16 mins ago People who possess a specific change in one of their chromosomes are nearly 14 times more likely to develop an autism spectrum disorder or schizophrenia than those without this change, according to a new study. The change, which is called a deletion, happens when a section of chromosome 17 is missing. The deletion is found only in people who have an autism spectrum disorder, a developmental delay or schizophrenia, said study researcher H. Ledbetter, a genetics professor at Emory University. " This is just adding one more to that rapidly growing list of genetic mutations " associated with autism that doctors could use to measure autism and schizophrenia risk in children, Ledbetter told MyHealthNewsDaily. Not all people with autism, a developmental delay or schizophrenia have this deletion. But all people who have the chromosome change will develop some form of the disorders, whether it's mild or strong enough for a diagnosis, he said. Schizophrenia and autism are separate disorders, but other recent research has also shown the two have genetic similarities. " At least in a subset of autism and a subset of schizophrenia, the same [genetic changes] play a major role in both, " Ledbetter said. " It will be interesting in the future, because we'll have the ability to identify this type of deletion in young children, and follow them to figure out why some of them do develop autism and some don't. " The new study was published today (Nov. 4) in the American Journal of Human Genetics. Detecting the deletion Researchers looked in a genetic database of 15,749 people with a developmental delay, intellectual disability or an autism spectrum disorder. They found 18 of these people had the deletion on chromosome 17. But not one of the 4,519 healthy people tested had the deletion, according to the study. Researchers tracked down nine of the 18 people in the database with the genetic deletion. All nine had cognitive impairments, and six of them had autism, the study said. To confirm these findings, researchers looked at two other databases that had genetic information for 7,522 people with autism or schizophrenia. They found the same deletion in two people with an autism spectrum disorder or cognitive impairment, and four adults with schizophrenia. None of the 43,076 healthy people tested had the deletion. " That means the deletion has a major phenotypic effect, " Ledbetter said. " It can manifest as developmental delay, intellectual disability or autism, or it may not be diagnosed and recognized until adulthood when there are psychiatric manifestations that lead to a diagnosis of schizophrenia. " In line with the research Some of the people with the deletion also had other health problems, such as renal cysts and diabetes. " We're starting to appreciate now that oftentimes, when we talk about psychiatric conditions, it doesn't really come just by itself, " said Andy Shih, vice president of science for the nonprofit Autism Speaks, who wasn't involved with the study. " A lot of times, you see a host of other conditions that travels with autism. " Previous work has found genes that are associated with autism, but these genes have " low penetrance " - meaning the genes were also found in people who don't have any symptoms of autism, said Rodier, a professor at the University of Rochester School of Medicine and Dentistry. " But in this case, it appears that virtually all of the people who have this anomaly of this gene have some symptoms, " said Rodier, who wasn't involved with the study. The new findings could be used in a genetic test that could help people confirm an autism or schizophrenia diagnosis, as well as determine their risk of developing one of these conditions, Rodier said. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 8, 2010 Report Share Posted November 8, 2010 Jill What is amazing is this guy ran a 15,700+ data pool looking for a genetic link and basically found nothing and still got published in science as a advancement instead of a dead end. This was more a proof that this is not genetic but he would not go there, probably due to ongoing research and funding. They are trying endlessly to prove that this is not a biological epidemic and can not get past there own tunnel vision. This is all due to the new gene sequencing technology and if they would run these same samples in a large scale study looking for viral RNA in the cellular mitochondria they would end this foolishness in short order. It is coming and very soon now! Bill ________________________________ From: Jill Boyer <sjillboyer@...> Sent: Mon, November 8, 2010 3:15:59 PM Subject: Re: Genome Article I know. I know. It is extremely frustrating. I do hope the research will go into another direction (yes, I do have the hope gene - which is why I get burned so often). Cheers, Jill From: Bill klimas <klimas_bill@...> Subject: Genome Article Date: Monday, November 8, 2010, 10:09 AM Guys Here is yet anther totally insignificant finding on chromosomal Damage. It reads like a break through until you do the math. They found a deletion in 18 out of 15000 kids on the spectrum and them published it as a major break though, Amazing! Crappy science without merit! They could have as easily looked for XMRV presence in 15,000 kids. Lets get he resources away from the genetics guys and send it to some viralologists. What a waste of money. Chromosome Change Points to Autism, SchizophreniaLiveScience.com " height= " 27 " width= " 73 " > * Buzz up!0 votes * Chan MyHealthNewsDaily Staff Writer LiveScience.com Chan myhealthnewsdaily Staff Writer livescience.com – 16 mins ago People who possess a specific change in one of their chromosomes are nearly 14 times more likely to develop an autism spectrum disorder or schizophrenia than those without this change, according to a new study. The change, which is called a deletion, happens when a section of chromosome 17 is missing. The deletion is found only in people who have an autism spectrum disorder, a developmental delay or schizophrenia, said study researcher H. Ledbetter, a genetics professor at Emory University. " This is just adding one more to that rapidly growing list of genetic mutations " associated with autism that doctors could use to measure autism and schizophrenia risk in children, Ledbetter told MyHealthNewsDaily. Not all people with autism, a developmental delay or schizophrenia have this deletion. But all people who have the chromosome change will develop some form of the disorders, whether it's mild or strong enough for a diagnosis, he said. Schizophrenia and autism are separate disorders, but other recent research has also shown the two have genetic similarities. " At least in a subset of autism and a subset of schizophrenia, the same [genetic changes] play a major role in both, " Ledbetter said. " It will be interesting in the future, because we'll have the ability to identify this type of deletion in young children, and follow them to figure out why some of them do develop autism and some don't. " The new study was published today (Nov. 4) in the American Journal of Human Genetics. Detecting the deletion Researchers looked in a genetic database of 15,749 people with a developmental delay, intellectual disability or an autism spectrum disorder. They found 18 of these people had the deletion on chromosome 17. But not one of the 4,519 healthy people tested had the deletion, according to the study. Researchers tracked down nine of the 18 people in the database with the genetic deletion. All nine had cognitive impairments, and six of them had autism, the study said. To confirm these findings, researchers looked at two other databases that had genetic information for 7,522 people with autism or schizophrenia. They found the same deletion in two people with an autism spectrum disorder or cognitive impairment, and four adults with schizophrenia. None of the 43,076 healthy people tested had the deletion. " That means the deletion has a major phenotypic effect, " Ledbetter said. " It can manifest as developmental delay, intellectual disability or autism, or it may not be diagnosed and recognized until adulthood when there are psychiatric manifestations that lead to a diagnosis of schizophrenia. " In line with the research Some of the people with the deletion also had other health problems, such as renal cysts and diabetes. " We're starting to appreciate now that oftentimes, when we talk about psychiatric conditions, it doesn't really come just by itself, " said Andy Shih, vice president of science for the nonprofit Autism Speaks, who wasn't involved with the study. " A lot of times, you see a host of other conditions that travels with autism. " Previous work has found genes that are associated with autism, but these genes have " low penetrance " - meaning the genes were also found in people who don't have any symptoms of autism, said Rodier, a professor at the University of Rochester School of Medicine and Dentistry. " But in this case, it appears that virtually all of the people who have this anomaly of this gene have some symptoms, " said Rodier, who wasn't involved with the study. The new findings could be used in a genetic test that could help people confirm an autism or schizophrenia diagnosis, as well as determine their risk of developing one of these conditions, Rodier said. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 9, 2010 Report Share Posted November 9, 2010 I wonder how much money was spent on this study, which doesnt lead to helping families in any way. -Jen > > Guys > Here is yet anther totally insignificant finding on chromosomal Damage. It reads > like a break through until you do the math. They found a deletion in 18 out of > 15000 kids on the spectrum and them published it as a major break though, > Amazing! > > Crappy science without merit! They could have as easily looked for XMRV presence > in 15,000 kids. Lets get he resources away from the genetics guys and send it to > some viralologists. What a waste of money. > > > Chromosome Change Points to Autism, SchizophreniaLiveScience.com " height= " 27 " > width= " 73 " > > > * Buzz up!0 votes > * > > Chan > MyHealthNewsDaily Staff Writer > LiveScience.com Chan > myhealthnewsdaily Staff Writer > livescience.com †" 16 mins ago > People who possess a specific change in one of their chromosomes are nearly 14 > times more likely to develop an autism spectrum disorder or schizophrenia than > those without this change, according to a new study. > The change, which is called a deletion, happens when a section of chromosome 17 > is missing. The deletion is found only in people who have an autism spectrum > disorder, a developmental delay or schizophrenia, said study researcher H. > Ledbetter, a genetics professor at Emory University. > " This is just adding one more to that rapidly growing list of genetic mutations " > associated with autism that doctors could use to measure autism and > schizophrenia risk in children, Ledbetter told MyHealthNewsDaily. > Not all people with autism, a developmental delay or schizophrenia have this > deletion. But all people who have the chromosome change will develop some form > of the disorders, whether it's mild or strong enough for a diagnosis, he said. > Schizophrenia and autism are separate disorders, but other recent research has > also shown the two have genetic similarities. > " At least in a subset of autism and a subset of schizophrenia, the same [genetic > changes] play a major role in both, " Ledbetter said. " It will be interesting in > the future, because we'll have the ability to identify this type of deletion in > young children, and follow them to figure out why some of them do develop > autism and some don't. " > The new study was published today (Nov. 4) in the American Journal of Human > Genetics. > Detecting the deletion > Researchers looked in a genetic database of 15,749 people with a developmental > delay, intellectual disability or an autism spectrum disorder. > They found 18 of these people had the deletion on chromosome 17. But not one of > the 4,519 healthy people tested had the deletion, according to the study. > Researchers tracked down nine of the 18 people in the database with the genetic > deletion. All nine had cognitive impairments, and six of them had autism, the > study said. > To confirm these findings, researchers looked at two other databases that had > genetic information for 7,522 people with autism or schizophrenia. They found > the same deletion in two people with an autism spectrum disorder or cognitive > impairment, and four adults with schizophrenia. None of the 43,076 healthy > people tested had the deletion. > " That means the deletion has a major phenotypic effect, " Ledbetter said. " It > can manifest as developmental delay, intellectual disability or autism, or it > may not be diagnosed and recognized until adulthood when there are psychiatric > manifestations that lead to a diagnosis of schizophrenia. " > In line with the research > Some of the people with the deletion also had other health problems, such as > renal cysts and diabetes. > " We're starting to appreciate now that oftentimes, when we talk about > psychiatric conditions, it doesn't really come just by itself, " said Andy Shih, > vice president of science for the nonprofit Autism Speaks, who wasn't involved > with the study. " A lot of times, you see a host of other conditions that > travels with autism. " > Previous work has found genes that are associated with autism, but these genes > have " low penetrance " - meaning the genes were also found in people who don't > have any symptoms of autism, said Rodier, a professor at the > University of Rochester School of Medicine and Dentistry. > " But in this case, it appears that virtually all of the people who have this > anomaly of this gene have some symptoms, " said Rodier, who wasn't involved with > the study. > > The new findings could be used in a genetic test that could help people confirm > an autism or schizophrenia diagnosis, as well as determine their risk of > developing one of these conditions, Rodier said. > > > > > Quote Link to comment Share on other sites More sharing options...
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