Antioxidant activity of fluoxetine

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http://www.ncbi.nlm.nih.gov/pubmed/20803706

Cell Biochem Funct. 2010 Aug;28(6):497-502.

Antioxidant activity of fluoxetine: Studies in mice melanoma model.

Kirkova M, Tzvetanova E, Vircheva S, Zamfirova R, Grygier B, Kubera M.

Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Abstract

In vivo effects of the antidepressant fluoxetine on spleen antioxidant status of

C57BL/6 mice were studied using a melanoma experimental model. After a 14-day

treatment with fluoxetine (10 mg kg(-1) day(-1), i.p.), the endogenous

antioxidant non-enzyme (glutathione) and enzyme (superoxide dismutase (SOD) and

glutathione peroxidase (GPx)) defense systems in spleen of healthy animals were

not changed; the lipid peroxidation (LP) was also unchanged. When B16F10

melanoma cells were introduced in C57BL/6 mice 2 h before fluoxetine treatment,

a drug-protective effect against the melanoma-induced oxidative changes

(increased LP and decreased total glutathione (GSH)-level, as well as

antioxidant enzyme activities) in spleen was observed. Fluoxetine

dose-dependently reduced the amounts of free oxygen radicals (hydroxyl and

superoxide anion radicals), generated in chemical systems. Taken together, the

present results suggest that fluoxetine, acting as antioxidant, prevents from

melanoma-induced oxidative changes in mice spleen. Copyright © 2010 Wiley

& Sons, Ltd.

PMID: 20803706 [PubMed - in process]