More on Bb and connective tissue

[Guest guest]

The link to the PubMed article that I posted in my previous message, does not

link to the full article (which contains the data I cited). To get to the

complete article, just click on the link to it on that webpage.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96674/?tool=pubmed

The full article summs up the research on Bb as follows (quoted from the final

paragraph):

" B. burgdorferi is found primarily in connective tissue of the affected organs

in Lyme disease. Colonization of this niche is likely to require localized

degradation of the insoluble matrix, which as we have shown cannot be

accomplished by the organisms themselves but can be achieved by the organisms

with surface-bound plasmin. The resulting proinflammatory degradation products

are also likely to contribute to the focal inflammation characteristic of the

affected tissues in Lyme disease. "

Note that the above paragraph states that Bb occupies the " connective tissue of

the affected organs " , which could be any area of the body and brain containing

connective tissue, which makes up the extracellular matrix (meaning anywhere in

the body, and not just in the joints).

Just how the Bb organism gets the help of the body's own mechanisms to " break

down " its own connective tissues (via pro-inflammatory responses), by use of

molecular deception using the host's own plasmids (for which it has receptors),

is fascinating (and scary). I'm still in the proceess of trying to grasp this

concept. Inflammation of the host's body in a variety of ways, seems to be

primary in the case of Lyme, as well as the degradation and ultimate destruction

of connective tissues in affected areas (most likely Bb colonies with protective

biofilms).

I personally feel as if I have Lyme colonies in all of my joints and brain, and

I'm treating it, accordingly. Bb has proven itself to be steadfast amd

relentless, and I will not let my guard down ever again, even if I " feel " well.

- Jane

[Guest guest]

Jane,Thanks for being a little more active posting your experiences on Lyme. I have always respected your opinion and missed hearing from you when you weren't posting. I was particularly interested in your setback after feeling you had achieved remission because you were having a little alcohol with dinner. I have also learned from (music lady) about her setback when her Doug Coil stopped working.I have been coiling for 18 months and have made considerable"Whether it be good or bad, I hope I will always take responsibility for my life."

The link to the PubMed article that I posted in my previous message, does not link to the full article (which contains the data I cited). To get to the complete article, just click on the link to it on that webpage.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96674/?tool=pubmed

The full article summs up the research on Bb as follows (quoted from the final paragraph):

"B. burgdorferi is found primarily in connective tissue of the affected organs in Lyme disease. Colonization of this niche is likely to require localized degradation of the insoluble matrix, which as we have shown cannot be accomplished by the organisms themselves but can be achieved by the organisms with surface-bound plasmin. The resulting proinflammatory degradation products are also likely to contribute to the focal inflammation characteristic of the affected tissues in Lyme disease."

Note that the above paragraph states that Bb occupies the "connective tissue of the affected organs", which could be any area of the body and brain containing connective tissue, which makes up the extracellular matrix (meaning anywhere in the body, and not just in the joints).

Just how the Bb organism gets the help of the body's own mechanisms to "break down" its own connective tissues (via pro-inflammatory responses), by use of molecular deception using the host's own plasmids (for which it has receptors), is fascinating (and scary). I'm still in the proceess of trying to grasp this concept. Inflammation of the host's body in a variety of ways, seems to be primary in the case of Lyme, as well as the degradation and ultimate destruction of connective tissues in affected areas (most likely Bb colonies with protective biofilms).

I personally feel as if I have Lyme colonies in all of my joints and brain, and I'm treating it, accordingly. Bb has proven itself to be steadfast amd relentless, and I will not let my guard down ever again, even if I "feel" well.

- Jane

[Guest guest]

To Jane Continued,Whoops! I hit send by mistake. As I was saying, I've made considerable Progress in the last 18 months and don't want to have a setback. I'm thinking I may need to keep coiling the remainder of my life even if I think I am in remission. It's not worth having it come back on you.Thanks for your valuable insight.Steve"Whether it be good or bad, I hope I will always take responsibility for my life."

The link to the PubMed article that I posted in my previous message, does not link to the full article (which contains the data I cited). To get to the complete article, just click on the link to it on that webpage.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96674/?tool=pubmed

The full article summs up the research on Bb as follows (quoted from the final paragraph):

"B. burgdorferi is found primarily in connective tissue of the affected organs in Lyme disease. Colonization of this niche is likely to require localized degradation of the insoluble matrix, which as we have shown cannot be accomplished by the organisms themselves but can be achieved by the organisms with surface-bound plasmin. The resulting proinflammatory degradation products are also likely to contribute to the focal inflammation characteristic of the affected tissues in Lyme disease."

Note that the above paragraph states that Bb occupies the "connective tissue of the affected organs", which could be any area of the body and brain containing connective tissue, which makes up the extracellular matrix (meaning anywhere in the body, and not just in the joints).

Just how the Bb organism gets the help of the body's own mechanisms to "break down" its own connective tissues (via pro-inflammatory responses), by use of molecular deception using the host's own plasmids (for which it has receptors), is fascinating (and scary). I'm still in the proceess of trying to grasp this concept. Inflammation of the host's body in a variety of ways, seems to be primary in the case of Lyme, as well as the degradation and ultimate destruction of connective tissues in affected areas (most likely Bb colonies with protective biofilms).

I personally feel as if I have Lyme colonies in all of my joints and brain, and I'm treating it, accordingly. Bb has proven itself to be steadfast amd relentless, and I will not let my guard down ever again, even if I "feel" well.

- Jane