Amoxicillin-induced flair/effect on HHV6 replication

[Guest guest]

Dr G has said in the past that amoxicillin and augmentin (and one more a) have

an effect on the immune system that is not desirable in .

Here's an example that Jay posted on another list:

Eur J Dermatol. 2010 Jan-Feb;20(1):68-73. Epub 2009 Oct 12.

Amoxicillin-induced flare in patients with DRESS (Drug Reaction with

Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of

a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro.

Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K, Barbaud

A, Crickx B, Ranger-Rogez S, Descamps V.

Department of Virology, Centre Hospitalier Universitaire Dupuytren, Limoges,

France.

Abstract

Amoxicillin is known to induce exanthema in patients with EBV-induced infectious

mononucleosis. It is widely recognized that the reactivation of herpesviruses,

including HHV-6 (Human Herpesvirus 6) and EBV (Epstein Barr virus) is associated

with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). We report 7

cases of amoxicillin-induced flare in patients with DRESS induced by other drugs

and investigate whether amoxicillin may have a direct effect on HHV-6

replication in vitro. 7 cases of DRESS with amoxicillin-induced flare were

retrospectively analysed. The influence of amoxicillin on HHV-6 HST strain

replication was studied in vitro in a human T lymphoblastoid MT4 cell line. The

viral replication was quantified by immunofluorescence assay and by real-time

polymerase chain reaction (PCR). Comparisons were performed using the Student's

t test. Amoxicillin-induced flare was observed in 7 patients with DRESS induced

by other drugs. In two cases HHV-6 reactivation was studied and was demonstrated

by PCR. Amoxicillin neither modified cell viability nor cell proliferation for

the range of tested concentrations.

Amoxicillin increased the replication of HHV-6 at 25 microg*mL-1 and 50

microg*mL-1. Amoxicillin may induce a flare of DRESS, possibly by acting

directly on herpesvirus replication.

[Guest guest]

>

> Dr G has said in the past that amoxicillin and augmentin (and one more a) have

> an effect on the immune system that is not desirable in .

>

> Here's an example that Jay posted on another list:

>

> Eur J Dermatol. 2010 Jan-Feb;20(1):68-73. Epub 2009 Oct 12.

>

> Amoxicillin-induced flare in patients with DRESS (Drug Reaction with

> Eosinophilia and Systemic Symptoms): report of seven cases and demonstration

of

> a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro.

> Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K,

Barbaud

> A, Crickx B, Ranger-Rogez S, Descamps V.

>

> Department of Virology, Centre Hospitalier Universitaire Dupuytren, Limoges,

> France.

>

> Abstract

> Amoxicillin is known to induce exanthema in patients with EBV-induced

infectious

> mononucleosis. It is widely recognized that the reactivation of herpesviruses,

> including HHV-6 (Human Herpesvirus 6) and EBV (Epstein Barr virus) is

associated

> with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). We report

7

> cases of amoxicillin-induced flare in patients with DRESS induced by other

drugs

> and investigate whether amoxicillin may have a direct effect on HHV-6

> replication in vitro. 7 cases of DRESS with amoxicillin-induced flare were

> retrospectively analysed. The influence of amoxicillin on HHV-6 HST strain

> replication was studied in vitro in a human T lymphoblastoid MT4 cell line.

The

> viral replication was quantified by immunofluorescence assay and by real-time

> polymerase chain reaction (PCR). Comparisons were performed using the

Student's

> t test. Amoxicillin-induced flare was observed in 7 patients with DRESS

induced

> by other drugs. In two cases HHV-6 reactivation was studied and was

demonstrated

> by PCR. Amoxicillin neither modified cell viability nor cell proliferation for

> the range of tested concentrations.

>

> Amoxicillin increased the replication of HHV-6 at 25 microg*mL-1 and 50

> microg*mL-1. Amoxicillin may induce a flare of DRESS, possibly by acting

> directly on herpesvirus replication.

>

>

> Thanks for getting this info out now we know all the details about these meds

for our children.

Carole

>

>

[Guest guest]

Very interesting!

From: [mailto: ] On Behalf Of

chocolatiluv

Sent: December-16-10 8:37 PM

Subject: Re: Amoxicillin-induced flair/effect on HHV6 replication

>

> Dr G has said in the past that amoxicillin and augmentin (and one more a)

have

> an effect on the immune system that is not desirable in .

>

> Here's an example that Jay posted on another list:

>

> Eur J Dermatol. 2010 Jan-Feb;20(1):68-73. Epub 2009 Oct 12.

>

> Amoxicillin-induced flare in patients with DRESS (Drug Reaction with

> Eosinophilia and Systemic Symptoms): report of seven cases and

demonstration of

> a direct effect of amoxicillin on Human Herpesvirus 6 replication in

vitro.

> Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K,

Barbaud

> A, Crickx B, Ranger-Rogez S, Descamps V.

>

> Department of Virology, Centre Hospitalier Universitaire Dupuytren,

Limoges,

> France.

>

> Abstract

> Amoxicillin is known to induce exanthema in patients with EBV-induced

infectious

> mononucleosis. It is widely recognized that the reactivation of

herpesviruses,

> including HHV-6 (Human Herpesvirus 6) and EBV (Epstein Barr virus) is

associated

> with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). We

report 7

> cases of amoxicillin-induced flare in patients with DRESS induced by other

drugs

> and investigate whether amoxicillin may have a direct effect on HHV-6

> replication in vitro. 7 cases of DRESS with amoxicillin-induced flare were

> retrospectively analysed. The influence of amoxicillin on HHV-6 HST strain

> replication was studied in vitro in a human T lymphoblastoid MT4 cell

line. The

> viral replication was quantified by immunofluorescence assay and by

real-time

> polymerase chain reaction (PCR). Comparisons were performed using the

Student's

> t test. Amoxicillin-induced flare was observed in 7 patients with DRESS

induced

> by other drugs. In two cases HHV-6 reactivation was studied and was

demonstrated

> by PCR. Amoxicillin neither modified cell viability nor cell proliferation

for

> the range of tested concentrations.

>

> Amoxicillin increased the replication of HHV-6 at 25 microg*mL-1 and 50

> microg*mL-1. Amoxicillin may induce a flare of DRESS, possibly by acting

> directly on herpesvirus replication.

>

>

> Thanks for getting this info out now we know all the details about these

meds for our children.

Carole

>

>

[Guest guest]

My son regressed severly into autism, we lost him while on Augmentin. I always

wondered why, now I guess I know. I plan to bring this up when we visit a

doc this spring.

Rhonda Masengale

On Dec 16, 2010, at 6:14 PM, <thecolemans4@...> wrote:

> Dr G has said in the past that amoxicillin and augmentin (and one more a) have

> an effect on the immune system that is not desirable in .

>

> Here's an example that Jay posted on another list:

>

> Eur J Dermatol. 2010 Jan-Feb;20(1):68-73. Epub 2009 Oct 12.

>

> Amoxicillin-induced flare in patients with DRESS (Drug Reaction with

> Eosinophilia and Systemic Symptoms): report of seven cases and demonstration

of

> a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro.

> Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K,

Barbaud

> A, Crickx B, Ranger-Rogez S, Descamps V.

>

> Department of Virology, Centre Hospitalier Universitaire Dupuytren, Limoges,

> France.

>

> Abstract

> Amoxicillin is known to induce exanthema in patients with EBV-induced

infectious

> mononucleosis. It is widely recognized that the reactivation of herpesviruses,

> including HHV-6 (Human Herpesvirus 6) and EBV (Epstein Barr virus) is

associated

> with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). We report

7

> cases of amoxicillin-induced flare in patients with DRESS induced by other

drugs

> and investigate whether amoxicillin may have a direct effect on HHV-6

> replication in vitro. 7 cases of DRESS with amoxicillin-induced flare were

> retrospectively analysed. The influence of amoxicillin on HHV-6 HST strain

> replication was studied in vitro in a human T lymphoblastoid MT4 cell line.

The

> viral replication was quantified by immunofluorescence assay and by real-time

> polymerase chain reaction (PCR). Comparisons were performed using the

Student's

> t test. Amoxicillin-induced flare was observed in 7 patients with DRESS

induced

> by other drugs. In two cases HHV-6 reactivation was studied and was

demonstrated

> by PCR. Amoxicillin neither modified cell viability nor cell proliferation for

> the range of tested concentrations.

>

> Amoxicillin increased the replication of HHV-6 at 25 microg*mL-1 and 50

> microg*mL-1. Amoxicillin may induce a flare of DRESS, possibly by acting

> directly on herpesvirus replication.

>

>

[Guest guest]

My son took Amoxicillin often as an infant and toddler. He was having some mild

delays until age 4 when he took amoxicillin for an ear infection and he totally

spiraled down into autism for 3 days. Lost eye contact, wouldn't play with

toys, just sat and spinned around in circles.

I took him off the Amoxicillin and tried to figure out if it was a reaction to

the med, but our doctor just didn't believe me. The doctor didn't t think

amoxicillin caused any of his problems. He got a little better after getting

off it, but never got back to where he was before the reaction.

He is 10 years old now and I am more confused than ever. We are trying ,

but not seeing much improvement after 7 months. He is diagnosed with PDD-NOS,

and Childhood Distintegrative Disorder. He has many symptoms of autism, but

isn't like any other " autistic " kid I know. He has so many delays. Very low

large motor skills, and hardly any fine motor skills. Hardly any communication

skills...No clue what the word " no " means.

[Guest guest]

Is there any possibility that he was exposed to a particular bacteria that

triggered his spiral?  Has he been properly screened/tested for Lyme and co

infections.  My daughter has Lyme and Bartonella which affects her CNS and

function.  She is taking zythromax and bactrim now and making

improvements...she

is worse with Amoxicillin.  Just a thought.

________________________________

From: TAMMYandRYAN K <rtnkraft_1@...>

nids < >

Sent: Mon, December 20, 2010 10:10:24 AM

Subject: Re: Amoxicillin-induced flair/effect on HHV6 replication

 

My son took Amoxicillin often as an infant and toddler. He was having some mild

delays until age 4 when he took amoxicillin for an ear infection and he totally

spiraled down into autism for 3 days. Lost eye contact, wouldn't play with toys,

just sat and spinned around in circles.

I took him off the Amoxicillin and tried to figure out if it was a reaction to

the med, but our doctor just didn't believe me. The doctor didn't t think

amoxicillin caused any of his problems. He got a little better after getting off

it, but never got back to where he was before the reaction.

He is 10 years old now and I am more confused than ever. We are trying , but

not seeing much improvement after 7 months. He is diagnosed with PDD-NOS, and

Childhood Distintegrative Disorder. He has many symptoms of autism, but isn't

like any other " autistic " kid I know. He has so many delays. Very low large

motor skills, and hardly any fine motor skills. Hardly any communication

skills...No clue what the word " no " means.