Mito dysfunction & Immune Dysfunction

[Guest guest]

Bill, & & Other experts,

Could you weigh in on these papers/articles about the oxidative stress, mito

dysfunction & immune dysfunction - sort of related in a cyclical positive

feedback type relationship as it seems. Specifically

the intracellular concentration of NADH & NADPH & MtDNA over replications.

I am curious if this is seen/studied in CFS or HIV infections - would this

explain increased Strep & other bacterial/fungal infections etc. Is their

decreased viral immunity to this?

Are there ways to test any of these in a lab?

http://www.ncbi.nlm.nih.gov/pubmed/21119085

http://jb.asm.org/cgi/content/full/189/18/6665

Thanks,

Kay

[Guest guest]

Kay, you didnt ask me but I will chime in here and say yes there is

mitochondrial dysfunction in autism but the cause, in my opinion, in most cases

is not a genetic one. There is a theory by Dr. Pall that explains that

mitochondrial dysfunction occurs due to an inflammatory cascade causing excess

Nitric Oxide in tissues, therefore impeding the mitochondrial process of making

ATP (the cell's energy source)

IF you take care of the source of the inflammation, you can stop local tissues

affected and mitochondria will function normally again.

Hope this helps,

Jen

>

> Bill, & & Other experts,

> Could you weigh in on these papers/articles about the oxidative stress, mito

> dysfunction & immune dysfunction - sort of related in a cyclical positive

> feedback type relationship as it seems. Specifically

> the intracellular concentration of NADH & NADPH & MtDNA over replications.

> I am curious if this is seen/studied in CFS or HIV infections - would this

> explain increased Strep & other bacterial/fungal infections etc. Is their

> decreased viral immunity to this?

> Are there ways to test any of these in a lab?

>

> http://www.ncbi.nlm.nih.gov/pubmed/21119085

> http://jb.asm.org/cgi/content/full/189/18/6665

>

> Thanks,

> Kay

>

>

>

>

>

[Guest guest]

Thanks !

I looked at Dr Pall's thetenthparidgm website which has some good information.

Do you know of tests that are done to measure the Nitric Oxide levels in tissues

or other tests that indicate this cycle impairment?

Are there any peadetricians that follow Dr Pall's research in clinical practice?

Thanks,

Kay

________________________________

From: <jlhank80@...>

Sent: Sun, January 23, 2011 8:16:50 PM

Subject: Re: Mito dysfunction & Immune Dysfunction

Kay, you didnt ask me but I will chime in here and say yes there is

mitochondrial dysfunction in autism but the cause, in my opinion, in most cases

is not a genetic one. There is a theory by Dr. Pall that explains that

mitochondrial dysfunction occurs due to an inflammatory cascade causing excess

Nitric Oxide in tissues, therefore impeding the mitochondrial process of making

ATP (the cell's energy source)

IF you take care of the source of the inflammation, you can stop local tissues

affected and mitochondria will function normally again.

Hope this helps,

Jen

>

> Bill, & & Other experts,

> Could you weigh in on these papers/articles about the oxidative stress, mito

> dysfunction & immune dysfunction - sort of related in a cyclical positive

> feedback type relationship as it seems. Specifically

> the intracellular concentration of NADH & NADPH & MtDNA over replications.

> I am curious if this is seen/studied in CFS or HIV infections - would this

> explain increased Strep & other bacterial/fungal infections etc. Is their

> decreased viral immunity to this?

> Are there ways to test any of these in a lab?

>

> http://www.ncbi.nlm.nih.gov/pubmed/21119085

> http://jb.asm.org/cgi/content/full/189/18/6665

>

> Thanks,

> Kay

>

>

>

>

>

[Guest guest]

I can't qualify as an expert.   I'll look over them, but right now, my OCD is

way down.  I started a new med - Amantadine, and it's helped my ocd so much ( &

improved my anxiety) that I can't even pull the research to find out what it's

doing to help me lol!  That's never happened before - that I don't track down

every tiny specific detail that I can.  Maybe I'll forget a few doses then I

can

weigth in better. 

Thanks for flattering me, though.  That was sweet.

I haven't even read the Pall theory on the NO/ONOO cycle, although I think it

has a lot of very good info that seems to be a little related to what you linked

to.  I've skimmed over it and it's so cool.  I think some of what you're

looking

at sounds similar to it.

I can only regurgitate what Dr Goldberg repeatedly told us back when he used to

spend hours on chat every Tuesday answering our questions, and I can repeat the

studies I've seen that I understand as they pertain to or support .  Get

into the intracellular stuff, & it's way over my head - especially lately.  I

swear when my OCD goes down, my IQ goes down with it.  Fine with me -

I'll accept being more normal in all ways. !

But my guess is that the virus is going to be primary, and the oxidative stress,

mito dysfunction, and the feedback cycles are going to be secondary to that

result.  just an uneducated guess that I base on how so many other things can

begin to normalize as an illness is overcome.

 

________________________________

From: Kay <kp_mlist@...>

Sent: Sat, January 22, 2011 2:43:17 PM

Subject: Mito dysfunction & Immune Dysfunction

 

Bill, & & Other experts,

Could you weigh in on these papers/articles about the oxidative stress, mito

dysfunction & immune dysfunction - sort of related in a cyclical positive

feedback type relationship as it seems. Specifically

the intracellular concentration of NADH & NADPH & MtDNA over replications.

I am curious if this is seen/studied in CFS or HIV infections - would this

explain increased Strep & other bacterial/fungal infections etc. Is their

decreased viral immunity to this?

Are there ways to test any of these in a lab?

http://www.ncbi.nlm.nih.gov/pubmed/21119085

http://jb.asm.org/cgi/content/full/189/18/6665

Thanks,

Kay

[Guest guest]

Hi ,

Thank you so much for always explaining things! I enjoy reading your

posts

Can I ask if you have experienced are any side effects like upset

stomach with Amantadine. I'll ask Dr. G about it on our next

appointment.

Thanks!

Argie

On Jan 30, 2011, at 9:38 PM, wrote:

> I can't qualify as an expert. I'll look over them, but right

> now, my OCD is

> way down. I started a new med - Amantadine, and it's helped my ocd

> so much ( &

> improved my anxiety) that I can't even pull the research to find out

> what it's

> doing to help me lol! That's never happened before - that I don't

> track down

> every tiny specific detail that I can. Maybe I'll forget a few

> doses then I can

> weigth in better.

> Thanks for flattering me, though. That was sweet.

>

> I haven't even read the Pall theory on the NO/ONOO cycle, although I

> think it

> has a lot of very good info that seems to be a little related to

> what you linked

> to. I've skimmed over it and it's so cool. I think some of what

> you're looking

> at sounds similar to it.

>

> I can only regurgitate what Dr Goldberg repeatedly told us back when

> he used to

> spend hours on chat every Tuesday answering our questions, and I can

> repeat the

> studies I've seen that I understand as they pertain to or support

> . Get

> into the intracellular stuff, & it's way over my head - especially

> lately. I

> swear when my OCD goes down, my IQ goes down with it. Fine with me -

> I'll accept being more normal in all ways. !

>

> But my guess is that the virus is going to be primary, and the

> oxidative stress,

> mito dysfunction, and the feedback cycles are going to be secondary

> to that

> result. just an uneducated guess that I base on how so many other

> things can

> begin to normalize as an illness is overcome.

>

>

>

>

>

> ________________________________

> From: Kay <kp_mlist@...>

>

> Sent: Sat, January 22, 2011 2:43:17 PM

> Subject: Mito dysfunction & Immune Dysfunction

>

>

> Bill, & & Other experts,

> Could you weigh in on these papers/articles about the oxidative

> stress, mito

> dysfunction & immune dysfunction - sort of related in a cyclical

> positive

> feedback type relationship as it seems. Specifically

> the intracellular concentration of NADH & NADPH & MtDNA over

> replications.

> I am curious if this is seen/studied in CFS or HIV infections -

> would this

> explain increased Strep & other bacterial/fungal infections etc. Is

> their

> decreased viral immunity to this?

> Are there ways to test any of these in a lab?

>

> http://www.ncbi.nlm.nih.gov/pubmed/21119085

> http://jb.asm.org/cgi/content/full/189/18/6665

>

> Thanks,

> Kay

>

>

[Guest guest]

My only side effect might be that I might clench my jaw a tiny bit more than i

already do.  Not sure.

I was having some violent stomach problems - intense vomiting and pain like

allergic or eosiniphilic gastritis, and within 3 days of amantadine, it's gone.

________________________________

From: Argie Olivo <golivo@...>

Sent: Mon, January 31, 2011 10:56:30 AM

Subject: Re: Mito dysfunction & Immune Dysfunction

Hi ,

Thank you so much for always explaining things!  I enjoy reading your 

posts

Can I ask if you have experienced are any side effects like upset 

stomach with Amantadine.  I'll ask Dr. G about it on our next 

appointment.

Thanks!

Argie

On Jan 30, 2011, at 9:38 PM, wrote:

> I can't qualify as an expert.   I'll look over them, but right 

> now, my OCD is

> way down.  I started a new med - Amantadine, and it's helped my ocd 

> so much ( &

> improved my anxiety) that I can't even pull the research to find out 

> what it's

> doing to help me lol!  That's never happened before - that I don't 

> track down

> every tiny specific detail that I can.  Maybe I'll forget a few 

> doses then I can

> weigth in better. 

> Thanks for flattering me, though.  That was sweet.

>

> I haven't even read the Pall theory on the NO/ONOO cycle, although I 

> think it

> has a lot of very good info that seems to be a little related to 

> what you linked

> to.  I've skimmed over it and it's so cool.  I think some of what 

> you're looking

> at sounds similar to it.

>

> I can only regurgitate what Dr Goldberg repeatedly told us back when 

> he used to

> spend hours on chat every Tuesday answering our questions, and I can 

> repeat the

> studies I've seen that I understand as they pertain to or support 

> .  Get

> into the intracellular stuff, & it's way over my head - especially 

> lately.  I

> swear when my OCD goes down, my IQ goes down with it.  Fine with me -

> I'll accept being more normal in all ways. !

>

> But my guess is that the virus is going to be primary, and the 

> oxidative stress,

> mito dysfunction, and the feedback cycles are going to be secondary 

> to that

> result.  just an uneducated guess that I base on how so many other 

> things can

> begin to normalize as an illness is overcome.

>

>

>

>

>

> ________________________________

> From: Kay <kp_mlist@...>

>

> Sent: Sat, January 22, 2011 2:43:17 PM

> Subject: Mito dysfunction & Immune Dysfunction

>

>

> Bill, & & Other experts,

> Could you weigh in on these papers/articles about the oxidative 

> stress, mito

> dysfunction & immune dysfunction - sort of related in a cyclical 

> positive

> feedback type relationship as it seems. Specifically

> the intracellular concentration of NADH & NADPH & MtDNA over 

> replications.

> I am curious if this is seen/studied in CFS or HIV infections - 

> would this

> explain increased Strep & other bacterial/fungal infections etc. Is 

> their

> decreased viral immunity to this?

> Are there ways to test any of these in a lab?

>

> http://www.ncbi.nlm.nih.gov/pubmed/21119085

> http://jb.asm.org/cgi/content/full/189/18/6665

>

> Thanks,

> Kay

>

>

[Guest guest]

Expert or not - we enjoy your posts & find it informative.

So does Dr G prescribe Amantadine?

________________________________

From: <thecolemans4@...>

Sent: Sun, January 30, 2011 9:38:46 PM

Subject: Re: Mito dysfunction & Immune Dysfunction

I can't qualify as an expert. I'll look over them, but right now, my OCD is

way down. I started a new med - Amantadine, and it's helped my ocd so much ( &

improved my anxiety) that I can't even pull the research to find out what it's

doing to help me lol! That's never happened before - that I don't track down

every tiny specific detail that I can. Maybe I'll forget a few doses then I can

weigth in better.

Thanks for flattering me, though. That was sweet.

I haven't even read the Pall theory on the NO/ONOO cycle, although I think it

has a lot of very good info that seems to be a little related to what you linked

to. I've skimmed over it and it's so cool. I think some of what you're looking

at sounds similar to it.

I can only regurgitate what Dr Goldberg repeatedly told us back when he used to

spend hours on chat every Tuesday answering our questions, and I can repeat the

studies I've seen that I understand as they pertain to or support . Get

into the intracellular stuff, & it's way over my head - especially lately. I

swear when my OCD goes down, my IQ goes down with it. Fine with me -

I'll accept being more normal in all ways. !

But my guess is that the virus is going to be primary, and the oxidative stress,

mito dysfunction, and the feedback cycles are going to be secondary to that

result. just an uneducated guess that I base on how so many other things can

begin to normalize as an illness is overcome.

________________________________

From: Kay <kp_mlist@...>

Sent: Sat, January 22, 2011 2:43:17 PM

Subject: Mito dysfunction & Immune Dysfunction

Bill, & & Other experts,

Could you weigh in on these papers/articles about the oxidative stress, mito

dysfunction & immune dysfunction - sort of related in a cyclical positive

feedback type relationship as it seems. Specifically

the intracellular concentration of NADH & NADPH & MtDNA over replications.

I am curious if this is seen/studied in CFS or HIV infections - would this

explain increased Strep & other bacterial/fungal infections etc. Is their

decreased viral immunity to this?

Are there ways to test any of these in a lab?

http://www.ncbi.nlm.nih.gov/pubmed/21119085

http://jb.asm.org/cgi/content/full/189/18/6665

Thanks,

Kay

[Guest guest]

I don't think he does.  It was pretty much a rescue for me, & it happened to

work very well for me. 

________________________________

From: Kay <kp_mlist@...>

Sent: Mon, January 31, 2011 11:57:30 PM

Subject: Re: Mito dysfunction & Immune Dysfunction

 

Expert or not - we enjoy your posts & find it informative.

So does Dr G prescribe Amantadine?

________________________________

From: <thecolemans4@...>

Sent: Sun, January 30, 2011 9:38:46 PM

Subject: Re: Mito dysfunction & Immune Dysfunction

I can't qualify as an expert. I'll look over them, but right now, my OCD is

way down. I started a new med - Amantadine, and it's helped my ocd so much ( &

improved my anxiety) that I can't even pull the research to find out what it's

doing to help me lol! That's never happened before - that I don't track down

every tiny specific detail that I can. Maybe I'll forget a few doses then I can

weigth in better.

Thanks for flattering me, though. That was sweet.

I haven't even read the Pall theory on the NO/ONOO cycle, although I think it

has a lot of very good info that seems to be a little related to what you linked

to. I've skimmed over it and it's so cool. I think some of what you're looking

at sounds similar to it.

I can only regurgitate what Dr Goldberg repeatedly told us back when he used to

spend hours on chat every Tuesday answering our questions, and I can repeat the

studies I've seen that I understand as they pertain to or support . Get

into the intracellular stuff, & it's way over my head - especially lately. I

swear when my OCD goes down, my IQ goes down with it. Fine with me -

I'll accept being more normal in all ways. !

But my guess is that the virus is going to be primary, and the oxidative stress,

mito dysfunction, and the feedback cycles are going to be secondary to that

result. just an uneducated guess that I base on how so many other things can

begin to normalize as an illness is overcome.

________________________________

From: Kay <kp_mlist@...>

Sent: Sat, January 22, 2011 2:43:17 PM

Subject: Mito dysfunction & Immune Dysfunction

Bill, & & Other experts,

Could you weigh in on these papers/articles about the oxidative stress, mito

dysfunction & immune dysfunction - sort of related in a cyclical positive

feedback type relationship as it seems. Specifically

the intracellular concentration of NADH & NADPH & MtDNA over replications.

I am curious if this is seen/studied in CFS or HIV infections - would this

explain increased Strep & other bacterial/fungal infections etc. Is their

decreased viral immunity to this?

Are there ways to test any of these in a lab?

http://www.ncbi.nlm.nih.gov/pubmed/21119085

http://jb.asm.org/cgi/content/full/189/18/6665

Thanks,

Kay