Role of intracellular calcium ions in the physiopathology of fibromyalgia syndrome.

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Role of intracellular calcium ions in the physiopathology of fibromyalgia

syndrome.

Boll Soc Ital Biol Sper 2000 Jan-Feb;76(1-2):1-4

Magaldi M, Moltoni L, Biasi G, Marcolongo R.

Institute of Rheumatology, University of Siena, Policlinico Le e,

Viale Bracci 1, I-53100 Siena.

PMID: 11449822

Calcium ions have a key role in the physiology of muscular contraction:

changes in calcium ion concentration may be involved in the pathogenesis of

fibromyalgia. Although the plasmatic level of calcium in fibromyalgia

patients is always in the normal range, it seemed interesting to evaluate

the intracellular calcium concentration.

The study was carried out on two groups of subjects: 70 affected by

fibromyalgia and 40 healthy controls.

The results obtained show that in fibromyalgia patients the intracellular

calcium concentration is significantly reduced in comparison to that of

healthy controls: the reduced intracellular calcium concentration seems to

be a peculiar characteristic of fibromyalgia patients and may be

potentially responsible for muscular hypertonus.

The effective role of this anomaly in the physiopathology of fibromyalgia

and the potential role of drugs active on the calcium homeostasis are still

to be confirmed.