FW: [LymeInfo] [sci] Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

[Guest guest]

This is major.

Finally someone is investigating what the Lyme community has known for

years. Alzheimer's can be caused by a bacterial infection. Specifically

Chronic Lyme Disease...

" The results show a statistically significant association between

spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI =

8-60, N = 247). When neutral techniques recognizing all types of spirochetes

were used, or the highly prevalent periodontal pathogen Treponemas were

analyzed, spirochetes were observed in the brain in more than 90% of AD

cases "

Full report below...

www.lyme-resource.com

You can lead a person to a fact, but you can't make them think! -

[LymeInfo] [sci] Alzheimer's disease - a neurospirochetosis.

Analysis of the evidence following Koch's and Hill's criteria.

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence

following Koch's and Hill's criteria.

Judith Miklossy

Journal of Neuroinflammation, 2011 Aug 4;8(1):90.

http://dx.doi.org/10.1186/1742-2094-8-90

Abstract (provisional)

It is established that chronic spirochetal infection can cause slowly

progressive dementia, brain atrophy and amyloid deposition in late

neurosyphilis. Recently it has been suggested that various types of

spirochetes, in an analogous way to Treponema pallidum, could cause dementia

and may be involved in the pathogenesis of Alzheimer's disease (AD).

Here, we review all data available in the literature on the detection of

spirochetes in AD and critically analyze the association and causal

relationship between spirochetes and AD following established criteria of

Koch and Hill. The results show a statistically significant association

between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N =

247). When neutral techniques recognizing all types of spirochetes were

used, or the highly prevalent periodontal pathogen Treponemas were analyzed,

spirochetes were observed in the brain in more than 90% of AD cases.

Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed

and was 13 times more frequent in AD compared to controls. Periodontal

pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T.

maltophilum, T.

medium, T. socranskii) and Borrelia burgdorferi were detected using species

specific PCR and antibodies.

Importantly, co-infection with several spirochetes occurs in AD. The

pathological and biological hallmarks of AD were reproduced in vitro.

The analysis of reviewed data following Koch's and Hill's postulates shows a

probable causal relationship between neurospirochetosis and AD. Persisting

inflammation and amyloid deposition initiated and sustained by chronic

spirochetal infection form together with the various hypotheses suggested to

play a role in the pathogenesis of AD a comprehensive entity. As suggested

by Hill, once the probability of a causal relationship is established prompt

action is needed. Support and attention should be given to this field of AD

research. Spirochetal infection occurs years or decades before the

manifestation of dementia. As adequate antibiotic and anti-inflammatory

therapies are available, as in syphilis, one might prevent and eradicate

dementia.

http://dx.doi.org/10.1186/1742-2094-8-90

The open access article is available as a provisional .pdf file:

http://www.jneuroinflammation.com/content/pdf/1742-2094-8-90.pdf

The fully formatted PDF and HTML versions are in production.

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