Taxol

August 10, 2011

Hi All,

I mentioned this drug recently but I think the email I sent may have gotten

overlooked as spam. My wife sent the link to me and after reading it, as well as

doing some separate additional research myself, I find that this drug looks very

promising as a treatment for re-scarring in TSC. This could potentially be a

game changer the same way in which Viagra, which was meant originally for

pulmonary issues, became a viable solution for ED.

The drug is currently used as a treatment for cancer and has a number of side

effects which I understand researchers are investigating ways to minimize some

of the worst ones.

http://en.wikipedia.org/wiki/Paclitaxel

http://www.spinalcordrecovery.org/news-archive/Cancer-Drug-Found-to-Aid-Cell-Reg\

eneration-After-Spinal-Cord-Injury.php

http://biotechstrategyblog.com/2011/03/patients-with-spinal-cord-injury-may-bene\

fit-from-treatment-with-taxanes.html/

August 10, 2011

Thanks, ..let us pray! Randee

In a message dated 8/9/2011 7:28:30 P.M. Central Daylight Time,

dmayn1988@... writes:

Hi All,

I mentioned this drug recently but I think the email I sent may have

gotten overlooked as spam. My wife sent the link to me and after reading it, as

well as doing some separate additional research myself, I find that this

drug looks very promising as a treatment for re-scarring in TSC. This could

potentially be a game changer the same way in which Viagra, which was meant

originally for pulmonary issues, became a viable solution for ED.

The drug is currently used as a treatment for cancer and has a number of

side effects which I understand researchers are investigating ways to

minimize some of the worst ones.

_http://en.wikipedia.org/wiki/Paclitaxel_

(http://en.wikipedia.org/wiki/Paclitaxel)

_http://www.spinalcordrecovery.org/news-archive/Cancer-Drug-Found-to-Aid-Cel

l-Regeneration-After-Spinal-Cord-Injury.php_

(http://www.spinalcordrecovery.org/news-archive/Cancer-Drug-Found-to-Aid-Cell-Re\

generation-After-Spinal-Cor

d-Injury.php)

_http://biotechstrategyblog.com/2011/03/patients-with-spinal-cord-injury-may

-benefit-from-treatment-with-taxanes.html/_

(http://biotechstrategyblog.com/2011/03/patients-with-spinal-cord-injury-may-ben\

efit-from-treatment-with-tax

anes.html/)

August 10, 2011

When i have a new appointment i will ask this on The Univercity Medical

Center in Utrecht.

If it is also tested on patients with tetherecord / SB and if it is tested

on patients with CES (cauda syndrome)

Al i know i was asked but tested negative but know a new patient a

hernitation and one with a spine tumor.

Jan Willem

-----Oorspronkelijk bericht-----

From: dmayn1988

Sent: Wednesday, August 10, 2011 2:28 AM

To: tetheredspinalcord

Subject: Taxol

Hi All,

I mentioned this drug recently but I think the email I sent may have gotten

overlooked as spam. My wife sent the link to me and after reading it, as

well as doing some separate additional research myself, I find that this

drug looks very promising as a treatment for re-scarring in TSC. This could

potentially be a game changer the same way in which Viagra, which was meant

originally for pulmonary issues, became a viable solution for ED.

The drug is currently used as a treatment for cancer and has a number of

side effects which I understand researchers are investigating ways to

minimize some of the worst ones.

http://en.wikipedia.org/wiki/Paclitaxel

http://www.spinalcordrecovery.org/news-archive/Cancer-Drug-Found-to-Aid-Cell-Reg\

eneration-After-Spinal-Cord-Injury.php

http://biotechstrategyblog.com/2011/03/patients-with-spinal-cord-injury-may-bene\

fit-from-treatment-with-taxanes.html/

------------------------------------

NOT MEDICAL ADVICE. We Are Not Doctors.

Need help with list?Email Darlene: darlene_self@... or

: hollygolightly1916@...

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Links

August 10, 2011

Continu on this product Taxol

The Utrecht University has stopped the program

Cause the product becomes resistent.

It was tested on mice and never on human.

Lots patients aks for this programmes

But in Germany UK and the Netherlands this is strict a formality to get new

medication when it becomes on the market

Taxol is only used on Cancer patients to slow down dividing new cells after

the surgery.

Mostly chemotherapy is the first step make a tumor smaller.

recertefy: IMPORTANT FOR THE MESSAGE I SEND FIRST

The patient i mentioned both got more forms of cancer.

When i got test positive it can take years

the test about this Ec5 expiriance is not able to

And never tested on this for scar tissue reforming.

Just to terminate a big stabel tumor.

Both patients got a better quality of life but not survife of cancer.

Exaly both developed problems whit the liver.

But on the other hand, it is not the first time that they try to heal crar

tissue.

In Europe al medicines for that got approved.

Only The FDA is clear about it, it realy aggressif

The reason patiens are negatif for treathment is that it is used for a few

sort of cancer like breast and lung.

People like us get never dosed with this

Why they quit :

Short description :

(translated)

Tumors may become resistant against new therapy

The quest for chemotherapy without side effects based on the molecule ec5

has become a lot harder. The molecule is not the hoped-for achilles heel of

tumor cells. Researchers from the Department of Medical Oncology of the UMC

Utrecht describe that in the journal Current Biology of 8 October. Marvin

Tanenbaum, PhD student at the University of Utrecht, is first author of the

article.

Many anticancer drugs inhibit the cell division and cancer cells kill as

rapidly dividing. However, these resources have often side effects in

healthy, non-dividing cells. Scientists seek therefore to resources that

only intervene on cell division. Substances which inhibit the molecule Ec5

forms one of those promising new cancer medicines. Ec5 plays a crucial role

in cell division and tumor cells many parts would be an Ec5 inhibitor can

kill specific tumor cells. Multiple pharmaceutical companies are currently

testing Ec5 inhibitors in clinical trials.

Researchers of the UMC Utrecht put this research on loose screws. They let

in an article in Current Biology shows that the tumor cells without also

Ec5. The molecule Kif15 shows the function of Ec5 about being able to

accept. That is both good and bad news. It means that tumors can be

resistant against Ec5-inhibitors. But it also offers a starting point for

new cancer therapy: simultaneous inhibition of Ec5 and Kif15.

Both substances are needed during cell division. During cell division

doubles the DNA of a cell and it should be evenly distributed over the two

new cells. The Ec5 protein controls the formation of pull wires that the DNA

apart and spread over the new cells. Without Ec5 failed cell division and

cell death.

At least that was the idea. Researchers of the UMC Utrecht spurred the Kif15

protein. Kif15 is not normally critical for cell division, but now it turns

out that the work of Ec5 Kif15 all over it. This allows tumor cells treated

with Ec5 inhibitors may be sharing again. Simultaneous inhibition of Ec5 and

Kif15 leads in these cells that still dividing cells dying off.

Various forms of chemotherapy, such as taxol, derive their operation to

blocking of cell division by the formation of pull wires (or microtubules)

more difficult. These microtubules are also important, however, for normal,

non sharer, cells in the body, that is why chemotherapy often has many side

effects. The protein Ec5 seemed only in dividing cells play a role and

therefore an ideal candidate for chemotherapy with fewer or no side effects.

That is so not the case.

Prof. Dr. René Medema of the Department of Medical Oncology of the UMC

Utrecht led the investigation.

More information

Secretariat internal and external communication UMC Utrecht, 088 7557 483

Information told under this line is wrong and part of something else

-----------------------------------

-----Oorspronkelijk bericht-----

From: Jan Willem Weijers

Sent: Wednesday, August 10, 2011 4:32 AM

To: tetheredspinalcord

Subject: Re: Taxol