Article turned oxygen info w/Nitrates & 4 rx's named

February 22, 2012

I can't help it, I've just got to post this article, which for me turned into

oxygen info...What caught my interest in this article was the oxygen info

w/Nitrates, 2 anesthetic (benzocaine and xylocaine) drugs, 2 antibiotics

(dapsone and chloroquine).

Making it personal for me was I've been told has low natural oxygen

carrying abilities w/his blood (possibly genetic, possibly because of all the

toxins his body fights...the good news is that Immusist & oxygenated water like

the Kangen have helped some w/this). The fact that I react so poorly to nitrates

myself....I wonder if some of the " brain fog " (turning to a major stressful

histamine response of hives & w/enough that has included tonge swelling &

breathing problems)....may this just be the additional body stress from the

oxygen inhibitor properties these produce...hummmm. Either way, for my family

anyway, I think it's best I stay away from these items, including the rx's

named.

Statement of oxygen interaction info from the article (about 1/2 way into the

article): " The disorder can be inherited, as was the case with the Fugate

family, or caused by exposure to certain drugs and chemicals such as anesthetic

drugs like benzocaine and xylocaine. The carcinogen benzene and nitrites used as

meat additives can also be culprits, as well as certain antibiotics, including

dapsone and chloroquine. "

Article source (on Yahoo news today):

http://gma.yahoo.com/fugates-kentucky-skin-bluer-lake-louise-200247843--abc-news\

..html

Fugates of Kentucky: Skin Bluer than Lake Louise

By SUSAN DONALDSON JAMES | Good Morning America – 22 hours ago

" Benjy " so frightened maternity doctors with the color of his

skin -- " as Blue as Lake Louise " -- that he was rushed just hours after his

birth in 1975 to University of Kentucky Medical Center.

As a transfusion was being readied, the baby's grandmother suggested to doctors

that he looked like the " blue Fugates of Troublesome Creek. " Relatives described

the boy's great-grandmother Luna Fugate as " blue all over, " and " the bluest

woman I ever saw. "

In an unusual story that involves both genetics and geography, an entire family

from isolated Appalachia was tinged blue. Their ancestral line began six

generations earlier with a French orphan, Fugate, who settled in Eastern

Kentucky.

Doctors don't see much of the rare blood disorder today, because mountain people

have dispersed and the family gene pool is much more diverse.

But the Fugates' story still offers a window into a medical mystery that was

solved through modern genetics and the sleuth-like energy of Dr. Madison Cawein

III, a hematologist at the University of Kentucky's Lexington Medical Clinic.

Cawein died in 1985, but his family charts and blood samples led to a sharper

understanding of the recessive diseases that only surface if both parents carry

a defective gene.

The most detailed account, " Blue People of Troublesome Creek, " was published in

1982 by the University of Indiana's Trost, who described Benjy's skin as

" almost purple. "

The Fugate progeny had a genetic condition called methemoglobinemia, which was

passed down through a recessive gene and blossomed through intermarriage.

" It's a fascinating story, " said Dr. Ayalew Tefferi, a hematologist from

Minnesota's Mayo Clinic. " It also exemplifies the intersection between disease

and society, and the danger of misinformation and stigmatization. "

Methemoglobinemia is a blood disorder in which an abnormal amount of

methemoglobin -- a form of hemoglobin -- is produced, according to the National

Institutes for Health. Hemoglobin is responsible for distributing oxygen to the

body and without oxygen, the heart, brain and muscles can die.

In methemoglobinemia, the hemoglobin is unable to carry oxygen and it also makes

it difficult for unaffected hemoglobin to release oxygen effectively to body

tissues. Patients' lips are purple, the skin looks blue and the blood is

" chocolate colored " because it is not oxygenated, according to Tefferi.

" You almost never see a patient with it today, " he said. " It's a disease that

one learns about in medical school and it is infrequent enough to be on every

exam in hematology. "

The disorder can be inherited, as was the case with the Fugate family, or caused

by exposure to certain drugs and chemicals such as anesthetic drugs like

benzocaine and xylocaine. The carcinogen benzene and nitrites used as meat

additives can also be culprits, as well as certain antibiotics, including

dapsone and chloroquine.

The genetic form of methemoglobinemia is caused by one of several genetic

defects, according to Tefferi. The Fugates probably had a deficiency in the

enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for

recessive congenital methemoglobinemia.

Normally, people have less than about 1 percent of methemoglobin, a type of

hemoglobin that is altered by being oxidized so is useless in carrying oxygen in

the blood. When those levels rise to greater than 20 percent, heart

abnormalities and seizures and even death can occur.

But at levels of between 10 and 20 percent a person can develop blue skin

without any other symptoms. Most of blue Fugates never suffered any health

effects and lived into their 80s and 90s.

" If you are between 1 percent and 10 percent, no one knows you have an abnormal

level and this might be the case in a lot of unsuspecting patients, " he said.

Many other recessive gene diseases, such as sickle cell anemia, Tay Sachs and

cystic fibrosis can be lethal, he said.

" If I carry a bad recessive gene with a rare abnormality and married, the child

probably wouldn't be sick, because it's very rare to meet another person with

the [same] bad gene and the most frequent cause therefore is in-breeding, "

Tefferi said.

Such was the case with the Fugates.

Fugate came to Troublesome Creek from France in 1820 and family folklore

says he was blue. He married , who also carried the recessive

gene. Of their seven children, four were reported to be blue.

There were no railroads and few roads outside the region, so the community

remained small and isolated. The Fugates married other Fugate cousins and

families who lived nearby, with names like Combs, , Ritchie and .

Benjy's father, Alva showed Trost his family tree and remarked, " If you'll

notice -- I'm kin to myself, " according to Trost.

One of and Fugate's blue boys, Zachariah, married his mother's

sister. One of their sons, Levy, married a Ritchie girl and had eight children,

one of them Luna. Luna married E. and they had 13 children.

Benjy descended from the line.

Modern Fugates Still in Kentucky

ABCNews.com was unable to determine if is still alive -- he would

be 37 today. Trost writes that he eventually lost the blue tint to his skin, but

as a child his lips and fingernails still got blue when he was angry or cold.

His mother Hilda , who is 56, appears to still live in Hazard, Ky., but did

not answer calls to her home. Other relatives are scattered throughout Virginia

and Arkansas.

Most of what scientists know about the family was discovered by Cawein, the

grandson of Kentucky's poet laureate, who had done pioneering research on L-dopa

as a treatment for Parkinson's disease.

Later in 1965 he was famous for another reason. His wife was murdered by

chemical poisoning, but no one was ever indicted.

Cawein heard rumors about the Fugates while working at his Lexington clinic and

set off " tromping around the hills looking for blue people, " according to

Trost's account.

At an American Heart Association clinic in the town of Hazard, Cawein found a

nurse, Ruth Pendergrass, and she was willing to assist. She remembered a dark

blue woman who had come to the county health department on a frigid afternoon

seeking a blood test.

" Her face and her fingernails were almost indigo blue, " she told Trost. " It like

scared me to death. She looked like she was having a heart attack. I just knew

that patient was going to die right there in the health department, but she

wasn't a'tall alarmed. She told me that her family was the blue Combses who

lived up on Ball Creek. She was a sister to one of the Fugate women. "

More families were found -- Luke Combs, and and Ritchie, who were

" bluer'n hell " and embarrassed by their skin color.

Cawein and Pendergrass began to ask questions -- " Do you have any relatives who

are blue? " -- and mapped a family tree and took blood samples.

The doctor suspected methemoglobinemia and uncovered a 1960 report in the

Journal of Clinical Investigation. Dr. E. M. , who worked in public health

at the Arctic Research Center in Anchorage, had seen a recessive genetic trait

among Alaskans that turned their skin blue.

That suggested an inbred line that had been passed from generation to

generation. To get the disorder, a person would have to inherit two genes -- one

from each parent. When both parents have the trait, their children have a 25

percent chance of getting the disorder.

speculated these people lacked the enzyme diaphorase in their red blood

cells. Normally diaphorase converts methemoglobin back to hemoglobin.

All of the blue Fugates he tested had the enzyme deficiency, just like the

Alaskans had observed.

Their blood had accumulated so much of the blue molecule that it over-powered

the red hemoglobin that normally turns skin pink in most Caucasians.

The bluest of the bunch was Luna, and she lived a healthy life, bearing 13

children before she died at the age of 84.

As coal mining arrived in Kentucky in 1912 and the Fugates moved outside of

Troublesome Creek, the blue people began to disappear.

Doctors say Benjy likely carried only one gene for methemoglobinemia, because he

eventually had normal skin tones, and the likelihood of him marrying a woman

with the same recessive gene would have been small.

By the time reports appeared in the media on the disorder, the family was

upset with insinuations about in-breeding that fed into stereotypes of backwoods

Appalachia.

" There was a pain not seen in lab tests, " wrote Trost. " That was the pain of

being blue in a world that is mostly shades of white to black. "

March 2, 2012

It showed up as one of his big stressors on his recent Zyto. I recently had our

1st big practioner readings (I've been wanting to do this for several years & we

finally had MP run one w/his current special).

One of the most interesting things just happened. On Mon we ran the Zyto & it

showed MTHFR as his #3 stressor. I talked w/my neice that just lost her baby in

her 7+ mo of pregnancy....she just had genetic testing done...she was concerned

about celiac....she asked both her genetics doc & her ob doc...both said it

should not make a difference....uhhhmmmm..both docs looked further into the info

she gave them and walla...it can (I told her she's going to be a great mom

pushing those docs w/her mom intuition...she went ahead & did the testing in

spite of the docs brush off). She called to tell me 2 days later that her

genetic testing showed a double marker of MTHFR & she thought it was on her dads

side...I told her it's on her moms side (clinically my mom, her grandmother died

of colon cancer as she just turned 50...last year I turned older than my mom did

in her life. I also told her just showed energetic markers to it as

well...it all fits together to well to not put this in as one of our pieces.

We've been put on Folapro......

A spleen infection came up as #2 stressor...interesting enough our herbalist

told us one of his main core issues is an infection in his spleen....bingo for

us, puzzle piece showing up again.

I know....more info than you asked for...but interesting all the same.

The Poor Oxygen Metab. was his #5 stressor. I believe is would be higher if it

weren't that we are using oxygen treatments w/the Kangen ionized/alkalized water

& the Immusist both helping some w/the poor oxygen metabalism issues as well as

the Valkion.

Blessings,

Rita

>

> > I can't help it, I've just got to post this article, which for me

> > turned into oxygen info...What caught my interest in this article

> > was the oxygen info w/Nitrates, 2 anesthetic (benzocaine and

> > xylocaine) drugs, 2 antibiotics (dapsone and chloroquine).

> >

> > Making it personal for me was I've been told has low natural

> > oxygen carrying abilities w/his blood (possibly genetic, possibly

> > because of all the toxins his body fights...the good news is that

> > Immusist & oxygenated water like the Kangen have helped some w/

> > this). The fact that I react so poorly to nitrates myself....I

> > wonder if some of the " brain fog " (turning to a major stressful

> > histamine response of hives & w/enough that has included tonge

> > swelling & breathing problems)....may this just be the additional

> > body stress from the oxygen inhibitor properties these

> > produce...hummmm. Either way, for my family anyway, I think it's

> > best I stay away from these items, including the rx's named.

> >

> > Statement of oxygen interaction info from the article (about 1/2 way

> > into the article): " The disorder can be inherited, as was the case

> > with the Fugate family, or caused by exposure to certain drugs and

> > chemicals such as anesthetic drugs like benzocaine and xylocaine.

> > The carcinogen benzene and nitrites used as meat additives can also

> > be culprits, as well as certain antibiotics, including dapsone and

> > chloroquine. "

> >

> > Article source (on Yahoo news today):

> >

http://gma.yahoo.com/fugates-kentucky-skin-bluer-lake-louise-200247843--abc-news\

..html

> >

> > Fugates of Kentucky: Skin Bluer than Lake Louise

> > By SUSAN DONALDSON JAMES | Good Morning America – 22 hours ago

> >

> > " Benjy " so frightened maternity doctors with the

> > color of his skin -- " as Blue as Lake Louise " -- that he was rushed

> > just hours after his birth in 1975 to University of Kentucky Medical

> > Center.

> > As a transfusion was being readied, the baby's grandmother suggested

> > to doctors that he looked like the " blue Fugates of Troublesome

> > Creek. " Relatives described the boy's great-grandmother Luna Fugate

> > as " blue all over, " and " the bluest woman I ever saw. "

> > In an unusual story that involves both genetics and geography, an

> > entire family from isolated Appalachia was tinged blue. Their

> > ancestral line began six generations earlier with a French orphan,

> > Fugate, who settled in Eastern Kentucky.

> > Doctors don't see much of the rare blood disorder today, because

> > mountain people have dispersed and the family gene pool is much more

> > diverse.

> > But the Fugates' story still offers a window into a medical mystery

> > that was solved through modern genetics and the sleuth-like energy

> > of Dr. Madison Cawein III, a hematologist at the University of

> > Kentucky's Lexington Medical Clinic.

> > Cawein died in 1985, but his family charts and blood samples led to

> > a sharper understanding of the recessive diseases that only surface

> > if both parents carry a defective gene.

> > The most detailed account, " Blue People of Troublesome Creek, " was

> > published in 1982 by the University of Indiana's Trost, who

> > described Benjy's skin as " almost purple. "

> > The Fugate progeny had a genetic condition called methemoglobinemia,

> > which was passed down through a recessive gene and blossomed through

> > intermarriage.

> > " It's a fascinating story, " said Dr. Ayalew Tefferi, a hematologist

> > from Minnesota's Mayo Clinic. " It also exemplifies the intersection

> > between disease and society, and the danger of misinformation and

> > stigmatization. "

> > Methemoglobinemia is a blood disorder in which an abnormal amount of

> > methemoglobin -- a form of hemoglobin -- is produced, according to

> > the National Institutes for Health. Hemoglobin is responsible for

> > distributing oxygen to the body and without oxygen, the heart, brain

> > and muscles can die.

> > In methemoglobinemia, the hemoglobin is unable to carry oxygen and

> > it also makes it difficult for unaffected hemoglobin to release

> > oxygen effectively to body tissues. Patients' lips are purple, the

> > skin looks blue and the blood is " chocolate colored " because it is

> > not oxygenated, according to Tefferi.

> > " You almost never see a patient with it today, " he said. " It's a

> > disease that one learns about in medical school and it is infrequent

> > enough to be on every exam in hematology. "

> > The disorder can be inherited, as was the case with the Fugate

> > family, or caused by exposure to certain drugs and chemicals such as

> > anesthetic drugs like benzocaine and xylocaine. The carcinogen

> > benzene and nitrites used as meat additives can also be culprits, as

> > well as certain antibiotics, including dapsone and chloroquine.

> > The genetic form of methemoglobinemia is caused by one of several

> > genetic defects, according to Tefferi. The Fugates probably had a

> > deficiency in the enzyme called cytochrome-b5 methemoglobin

> > reductase, which is responsible for recessive congenital

> > methemoglobinemia.

> > Normally, people have less than about 1 percent of methemoglobin, a

> > type of hemoglobin that is altered by being oxidized so is useless

> > in carrying oxygen in the blood. When those levels rise to greater

> > than 20 percent, heart abnormalities and seizures and even death can

> > occur.

> > But at levels of between 10 and 20 percent a person can develop blue

> > skin without any other symptoms. Most of blue Fugates never suffered

> > any health effects and lived into their 80s and 90s.

> > " If you are between 1 percent and 10 percent, no one knows you have

> > an abnormal level and this might be the case in a lot of

> > unsuspecting patients, " he said.

> > Many other recessive gene diseases, such as sickle cell anemia, Tay

> > Sachs and cystic fibrosis can be lethal, he said.

> > " If I carry a bad recessive gene with a rare abnormality and

> > married, the child probably wouldn't be sick, because it's very rare

> > to meet another person with the [same] bad gene and the most

> > frequent cause therefore is in-breeding, " Tefferi said.

> > Such was the case with the Fugates.

> > Fugate came to Troublesome Creek from France in 1820 and

> > family folklore says he was blue. He married , who

> > also carried the recessive gene. Of their seven children, four were

> > reported to be blue.

> > There were no railroads and few roads outside the region, so the

> > community remained small and isolated. The Fugates married other

> > Fugate cousins and families who lived nearby, with names like Combs,

> > , Ritchie and .

> > Benjy's father, Alva showed Trost his family tree and

> > remarked, " If you'll notice -- I'm kin to myself, " according to Trost.

> > One of and Fugate's blue boys, Zachariah, married

> > his mother's sister. One of their sons, Levy, married a Ritchie girl

> > and had eight children, one of them Luna. Luna married E.

> > and they had 13 children.

> > Benjy descended from the line.

> > Modern Fugates Still in Kentucky

> > ABCNews.com was unable to determine if is still alive

> > -- he would be 37 today. Trost writes that he eventually lost the

> > blue tint to his skin, but as a child his lips and fingernails still

> > got blue when he was angry or cold.

> > His mother Hilda , who is 56, appears to still live in Hazard,

> > Ky., but did not answer calls to her home. Other relatives are

> > scattered throughout Virginia and Arkansas.

> > Most of what scientists know about the family was discovered by

> > Cawein, the grandson of Kentucky's poet laureate, who had done

> > pioneering research on L-dopa as a treatment for Parkinson's disease.

> > Later in 1965 he was famous for another reason. His wife was

> > murdered by chemical poisoning, but no one was ever indicted.

> > Cawein heard rumors about the Fugates while working at his Lexington

> > clinic and set off " tromping around the hills looking for blue

> > people, " according to Trost's account.

> > At an American Heart Association clinic in the town of Hazard,

> > Cawein found a nurse, Ruth Pendergrass, and she was willing to

> > assist. She remembered a dark blue woman who had come to the county

> > health department on a frigid afternoon seeking a blood test.

> > " Her face and her fingernails were almost indigo blue, " she told

> > Trost. " It like scared me to death. She looked like she was having a

> > heart attack. I just knew that patient was going to die right there

> > in the health department, but she wasn't a'tall alarmed. She told me

> > that her family was the blue Combses who lived up on Ball Creek. She

> > was a sister to one of the Fugate women. "

> > More families were found -- Luke Combs, and and

> > Ritchie, who were " bluer'n hell " and embarrassed by their skin color.

> > Cawein and Pendergrass began to ask questions -- " Do you have any

> > relatives who are blue? " -- and mapped a family tree and took blood

> > samples.

> > The doctor suspected methemoglobinemia and uncovered a 1960 report

> > in the Journal of Clinical Investigation. Dr. E. M. , who

> > worked in public health at the Arctic Research Center in Anchorage,

> > had seen a recessive genetic trait among Alaskans that turned their

> > skin blue.

> > That suggested an inbred line that had been passed from generation

> > to generation. To get the disorder, a person would have to inherit

> > two genes -- one from each parent. When both parents have the trait,

> > their children have a 25 percent chance of getting the disorder.

> > speculated these people lacked the enzyme diaphorase in their

> > red blood cells. Normally diaphorase converts methemoglobin back to

> > hemoglobin.

> > All of the blue Fugates he tested had the enzyme deficiency, just

> > like the Alaskans had observed.

> > Their blood had accumulated so much of the blue molecule that it

> > over-powered the red hemoglobin that normally turns skin pink in

> > most Caucasians.

> > The bluest of the bunch was Luna, and she lived a healthy life,

> > bearing 13 children before she died at the age of 84.

> > As coal mining arrived in Kentucky in 1912 and the Fugates moved

> > outside of Troublesome Creek, the blue people began to disappear.

> > Doctors say Benjy likely carried only one gene for

> > methemoglobinemia, because he eventually had normal skin tones, and

> > the likelihood of him marrying a woman with the same recessive gene

> > would have been small.

> > By the time reports appeared in the media on the disorder, the

> > family was upset with insinuations about in-breeding that fed into

> > stereotypes of backwoods Appalachia.

> > " There was a pain not seen in lab tests, " wrote Trost. " That was the

> > pain of being blue in a world that is mostly shades of white to

> > black. "

> >

>

March 3, 2012

Rita,

Have you had a hyper pagination panel run on Josh? That was one of the first

tests run on my kids when we started seeing our Lyme doctor. Both kids have

various issues with " thick " blood, thus causing o2 issues. Our doctor said 90%

of his Lyme patients have issues with hyper coagulation.

Sent from my iPhone

> It showed up as one of his big stressors on his recent Zyto. I recently had

our 1st big practioner readings (I've been wanting to do this for several years

& we finally had MP run one w/his current special).

> One of the most interesting things just happened. On Mon we ran the Zyto & it

showed MTHFR as his #3 stressor. I talked w/my neice that just lost her baby in

her 7+ mo of pregnancy....she just had genetic testing done...she was concerned

about celiac....she asked both her genetics doc & her ob doc....both said it