Guest guest Posted January 2, 2011 Report Share Posted January 2, 2011 Allie, I do not have a weblink to Dr. MC's presentation. The slides can be found in the File section of " LandauKleffnerSyndrome " Yahoo group. Dr. MC's own child has the diagnosis of LKS. He gave that presentation at a conference before he published the book titled " Autism and Its Medical Management: A Guide for Parents and Professionals " . I have not read the book but believe that the book covers the information in his presentation. http://www.amazon.com/Autism-Its-Medical-Management-Professionals/dp/1843108348/\ ref=sr_1_2?ie=UTF8 & s=books & qid=1294038889 & sr=8-2 Limin > Just wondered if you could send that link to me privately? > blessingsx10@... > TIA > Allie > > >> >> I found this info in one of Dr. MC's (a well known neurologist in Sacramento) old presentation decks: >> >> - elevated cytokines in epilepsy an autism include IL-1, IL-6, MCP-1, TNF-alpha, TNF-R1, BDNF, and others. >> - elevated inflammation may alter NMDA receptors and sensitivity to glutamate; also GABA receptors through neuroglial actions. These changes can occur pre- or post-natally. >> - These may also alter the superoxide dismutase activity levels and oxidative damage found by some researchers. >> - There may be unifying possibilities here with some of the white matter changes noted on MRI could be the result of this type of neuroglial inflammation, and some retrograde pontocerebellar tract degeneration can also be from the activity. >> >> Limin >> > > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
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