What brain inflammation, epilepsy, and autism have in common?

[Guest guest]

I found this info in one of Dr. MC's (a well known neurologist in Sacramento)

old presentation decks:

- elevated cytokines in epilepsy an autism include IL-1, IL-6, MCP-1,

TNF-alpha, TNF-R1, BDNF, and others.

- elevated inflammation may alter NMDA receptors and sensitivity to glutamate;

also GABA receptors through neuroglial actions. These changes can occur pre- or

post-natally.

- These may also alter the superoxide dismutase activity levels and oxidative

damage found by some researchers.

- There may be unifying possibilities here with some of the white matter

changes noted on MRI could be the result of this type of neuroglial

inflammation, and some retrograde pontocerebellar tract degeneration can also be

from the activity.

Limin

[Guest guest]

Just wondered if you could send that link to me privately?

blessingsx10@...

TIA

Allie

>

> I found this info in one of Dr. MC's (a well known neurologist in Sacramento)

old presentation decks:

>

> - elevated cytokines in epilepsy an autism include IL-1, IL-6, MCP-1,

TNF-alpha, TNF-R1, BDNF, and others.

> - elevated inflammation may alter NMDA receptors and sensitivity to

glutamate; also GABA receptors through neuroglial actions. These changes can

occur pre- or post-natally.

> - These may also alter the superoxide dismutase activity levels and oxidative

damage found by some researchers.

> - There may be unifying possibilities here with some of the white matter

changes noted on MRI could be the result of this type of neuroglial

inflammation, and some retrograde pontocerebellar tract degeneration can also be

from the activity.

>

> Limin

>