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----- Forwarded Message ----To: ecoartist1@...Sent: Mon, March 14, 2011 6:16:17 PMSubject: Chronic Illness Recovery - News From the Circle

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From the CircleA Newsletter from Chronic Illness Recovery

In This Issue

Therapy Tip

Survey Volunteers Needed

Inflammation Therapy

Scientific Articles

About CIR

Therapy Tip

Supplements such as alpha lipoic acid (ALA), DIM (Diindolylmethane), bromelain, NAC (N-acetylcysteine), milk thistle, chlorogenic acid, ginger, garlic and hawthorn can help maintain tolerable herxing. They do this by partially blocking the NF-κβ pathway (as Benicar does) to reduce inflammation. But, unlike Benicar, they don't (to our current knowledge) up-regulate VDR transcription of antimicrobial peptides (which increases herxing). Details of these anti-inflammatory supplements and other options for managing herxing are described in Herxheimer Symptom Management, an article in our Library of Information for registered readers (see below).Our Library

Access to our extensive, easy-to-read Library of Information (see this sample page)and Physicians' Reference Library is available to anyone, without enrollment in our counseling program. If you're interested in using this resource, please send your request toour email, along with your doctor's name and fax number (in the US and Canada) or his/her email address so we can notify your doctor that you have access to this information. A list of the articles in our library is availableat this link.

Physicians may use CIR libraries even if they don't have a patient enrolled in our counseling program. Interested medical professionals should contact CIR and ask to register.

CIR OrganizationCIR is an IRS-recognized

501©3 non-profit, charitable organization.Donations allow us to fulfill our mission and every gift is appreciated. Donate Online Here

Survey

Volunteers who have a diagnosis of autoimmune or inflammatory disease or are chronically ill but who are not being treated with Inflammation Therapy, the Marshall Protocol or the Stillpoint Protocol are needed to be in the control group of our clinical study.

If you meet these criteria and would like to take part in this project, please contact us at

via email.

Contact InformationCIR email addressPhone CIR toll-free in the US and Canada

1-Are you a Skype User?Look for Chronic.Illness.Recovery

Quotable Quotes

"My doctor was at the conference and it was so good to listen to him and see him in the larger context of all of this...all the health care professionals involved. It was wonderful to meet Meg, Belinda, P. Bear, .. Dr. Dodd and her fabulous Australian accent. Their intelligence, experience and understanding of this process and the time and work they have all given and continue to give towards this cause is nothing short of benevolent passionate care." - Alycia Goeke

Quick Links

What's NewGetting StartedAbout Inflammation

TherapyCIR Brochure

Issue: 18March 2011

Greetings!

Our first workshop for patients was a resounding success. Attendees came from around the USA and as far away as Australia, Mexico and Ireland to learn more about Inflammation Therapy and meet other patients.

Many enjoyed an informal gathering the evening before, and several of the medical practitioners who came to the seminar on Saturday also attended the Patient Workshop. The Hilton conference center was beautiful, the food was delicious and there were many opportunities for questions and sharing.

Dr. Barry Rodgers put it this way, "I am still marveling at what happened in Dallas last weekend; it was encouraging to me to see the genuine interest among those who attended, patient and doctor alike. Well done."

We've already made plans for the next Patient Workshop, so please mark your calendar for Sunday, February 19, 2012. We look forward to meeting you in Dallas-Fort Worth for another day of valuable learning and support.

Best regards,

About Inflammation Therapy

Patient Safety During Immunostimulative Therapies

Treatment protocols such as Inflammation Therapy resolve chronic inflammatory symptoms by stimulating the immune system to eliminate persistent pathogens. The resulting cellular death provokes Jarisch-Herxheimer reactions (i.e., immunopathology) which often cause hormonal, endocrine, and blood count changes.

The kidneys may be affected by subclinical

chronic inflammation, and must function well enough to eliminate additional toxins released as a result of the bacterial die-off. Mildly abnormal kidney function during treatment is common and not a cause for concern. However, because treatment often requires many years of immune system stimulation to resolve inflammation, it's vital that medical practitioners regularly monitor kidney function (BUN, creatinine, eGFR, proteinuria, electrolytes, B/P, 24 hour urine, cystatin C, etc.) to ensure these markers of health don't stray too far from normal and aren't continuing to trend in the wrong direction.

Kidney function lab results that are seriously out of range should not be ignored, nor should they be considered a normal part of the healing process. Seriously out of range KFTs do indicate renal stress that could result in permanent organ damage if waste products are allowed to accumulate. Anecdotal case reports include patients who have had to discontinue the treatment protocol in order to avoid dialysis.

However, the medical professionals at CIR have learned that reducing immunostimulation (i.e., upregulation of VDR transcription of antimicrobial peptides) by decreasing the dose of olmesartan (Benicar) is an effective strategy to improve worrisome kidney function so patients can safely continue their Inflammation Therapy. See

Benicar Dosing to Prevent Organ/Tissue Damage During Therapy. Scientific ArticlesHypoxia and InflammationA doctor at the University of Colorado, Holger K. Eltzschig, M.D., Ph.D., led this study on the relationship between hypoxia and inflammation. The results were published Feb. 17 in the New England Journal of Medicine. Eltzschig says that research now should focus on understanding more about the way these signals function. "By focusing on the molecular pathways the body uses to battle hypoxia, we may be able help patients who undergo organ transplants, who suffer from infections or who have cancer," says Eltzschig, a professor of anesthesiology, medicine, cell biology and immunology.The Nuclear Factor NF-κβ Pathway in Inflammation Toby Lawrence from the Inflammation Biology Group discusses the role of NF-κβ in inflammation in light of recent studies that suggest both pro- and anti-inflammatory roles for this pathway. Vitamin D3 down-regulates

monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns."Our data provide strong evidence that 1,25(OH)2D3 primes monocytes to respond less effectively to bacterial cell wall components in a VDR-dependent mechanism, most likely due to decreased levels of TLR2 and TLR4." About Chronic Illness Recovery

Chronic Illness Recovery (CIR) was founded to introduce physicians (and other medical practitioners) to Inflammation Therapy (IT) and to help them understand its management. We believe this is the best use of the limited professional resources available and that ultimately this approach will benefit the most patients, as more doctors recognize the effectiveness of IT and become comfortable in prescribing it.

Our counseling program helps patients and also serves to inform doctors about the management of IT. While we would like to be able to help everyone, we have to restrict ourselves to patients who have a supportive doctor willing to authorize their enrollment in our counseling service.

It's CIR's policy that we counsel patients in cooperation with their doctors for several reasons:

To ensure safety, patients must be under the care of a qualified medical practitioner.To fulfill our mission to help clinicians become confident practitioners of Inflammation Therapy. As registered nurses, we're required to work under the direction of a licensed medical practitioner.

You may have an easier time finding a doctor willing to order IT if you inform him/her that CIR help is available. We counsel many patients who are in complicated situations and we work with doctors all over the world.

If you'd like a list of medical practitioners, please send your request to

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